Tandem S_NAr/Aldol Condensation of Oxindoles with o-Haloacetophenones Enables Modular Assembly of 2,3-Fused Indolines Bearing a Quaternary Carbon

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Described herein is a novel base-promoted [4 + 2] annulation reaction of 3-methyl-indolin-2-ones with ortho-haloacetophenones, which enables the modular and reliable synthesis 2,3-fused indolines bearing quaternary carbon. Two C-C bonds can be successively constructed through tandem sequence involving SNAr aldol condensation. This protocol highlighted by transition metal-free conditions, high efficiency, simple operation.

Language: Английский

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Aromatic Deformylative Deuteration Enabled by Cobalt–Photocatalysis at Ambient Temperature

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 8522 - 8529

Published: May 6, 2025

Language: Английский

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Denitrative Iodination of Nitroarenes via Light-Promoted Reduction

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Aryl iodides are essential synthons in organic synthesis, whose conventional preparations often suffer from poor selectivity or necessitate multistep procedures. Herein, we present a light-driven denitrative iodination as one-step approach that directly converts nitroarenes to iodoarenes under mild and transition-metal-free conditions. This streamlined method operates the absence of strong Brønsted acids, ensuring broad functional group tolerance, including esters, cyano groups, halides, heterocycles, while also offering operational simplicity scalability.

Language: Английский

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Light-Promoted Direct Denitrative Chlorination of Non-Activated Nitroarenes

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(4), P. 1421 - 1421

Published: Jan. 1, 2025

Language: Английский

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