Widespread introgression across a phylogeny of 155 Drosophila genomes

Current Biology, Journal Year: 2021, Volume and Issue: 32(1), P. 111 - 123.e5

Published: Nov. 16, 2021

Language: Английский

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Prevalence and Adaptive Impact of Introgression

Annual Review of Genetics, Journal Year: 2021, Volume and Issue: 55(1), P. 265 - 283

Published: Sept. 28, 2021

Alleles that introgress between species can influence the evolutionary and ecological fate of exposed to novel environments. Hybrid offspring different are often unfit, yet it has long been argued introgression be a potent force in evolution, especially plants. Over last two decades, genomic data have increasingly provided evidence is critically important source genetic variation this additional useful adaptive evolution both animals Here, we review factors probability foreign variants provide long-term benefits (so-called introgression) discuss their potential benefits. We find plays an role particularly when far from its fitness optimum, such as they expand range or subject changing

Language: Английский

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Plant NLR diversity: the known unknowns of pan-NLRomes

The Plant Cell, Journal Year: 2021, Volume and Issue: 33(4), P. 814 - 831

Published: Jan. 1, 2021

Plants and pathogens constantly adapt to each other. As a consequence, many members of the plant immune system, especially intracellular nucleotide-binding site leucine-rich repeat receptors, also known as NOD-like receptors (NLRs), are highly diversified, both among family in same genome, between individuals species. While this diversity has long been appreciated, its true extent remained unknown. With pan-genome pan-NLRome studies becoming more comprehensive, our knowledge NLR sequence is growing rapidly, pan-NLRomes provide powerful platforms for assigning function NLRs. These efforts an important step toward goal comprehensively predicting from alone whether provides disease resistance, if so, which pathogens.

Language: Английский

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Phylogenomic approaches to detecting and characterizing introgression

Genetics, Journal Year: 2021, Volume and Issue: 220(2)

Published: Nov. 11, 2021

Abstract Phylogenomics has revealed the remarkable frequency with which introgression occurs across tree of life. These discoveries have been enabled by rapid growth methods designed to detect and characterize from whole-genome sequencing data. A large class phylogenomic makes use data species infer based on expectations multispecies coalescent. range simple tests, such as D-statistic, model-based approaches for inferring phylogenetic networks. Here, we provide a detailed overview various signals that different modes are expected leave in genome, how current them. We discuss strengths pitfalls these identify areas future development, highlighting introgression, power each method conclude discussion challenges they could potentially be addressed.

Language: Английский

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Evolutionary constraint and innovation across hundreds of placental mammals

Science, Journal Year: 2023, Volume and Issue: 380(6643)

Published: April 27, 2023

Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes 240 species, we identify bases that, when mutated, are likely affect fitness and alter disease risk. At least 332 million (~10.7%) in human genome unusually conserved across species (evolutionarily constrained) relative neutrally evolving repeats, 4552 ultraconserved elements nearly perfectly conserved. Of 101 significantly constrained single bases, 80% outside protein-coding exons half have no functional annotations Encyclopedia of DNA Elements (ENCODE) resource. Changes genes regulatory associated with exceptional mammalian traits, such as hibernation, that could inform therapeutic development. Earth's vast imperiled biodiversity offers distinctive power identifying genetic variants function organismal phenotypes.

Language: Английский

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Conservation and the Genomics of Populations

Oxford University Press eBooks, Journal Year: 2022, Volume and Issue: unknown

Published: Feb. 10, 2022

Abstract Loss of biodiversity is among the greatest problems facing world today. Conservation and Genomics Populations gives a comprehensive overview essential background, concepts, tools needed to understand how genetic information can be used conserve species threatened with extinction, manage ecological or commercial importance. New molecular techniques, statistical methods, computer programs, principles, methods are becoming increasingly useful in conservation biological diversity. Using balance data theory, coupled basic applied research examples, this book examines phenotypic variation natural populations, principles mechanisms evolutionary change, interpretation from these conservation. The includes examples plants, animals, microbes wild captive populations. This third edition has been thoroughly revised include advances genomics contains new chapters on population genomics, monitoring, genetics practice, as well sections climate emerging diseases, metagenomics, more. More than one-third references were published after previous edition. Each 24 Appendix end Guest Box written by an expert who provides example presented chapter their own work. for advanced undergraduate graduate students genetics, resource management, biology, professional biologists policy-makers working wildlife habitat management agencies. Much will also interest nonprofessionals curious about role

Language: Английский

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Natural hybridization reduces vulnerability to climate change

Nature Climate Change, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 30, 2023

Abstract Under climate change, species unable to track their niche via range shifts are largely reliant on genetic variation adapt and persist. Genomic vulnerability predictions used identify populations that lack the necessary variation, particularly at climate-relevant genes. However, hybridization as a source of novel adaptive is typically ignored in genomic studies. We estimated environmental models for closely related rainbowfish ( Melanotaenia spp.) across an elevational gradient Australian Wet Tropics. Hybrid between widespread generalist several narrow endemic exhibited reduced projected climates compared pure endemics. Overlaps introgressed regions were consistent with signal introgression. Our findings highlight often-underappreciated conservation value hybrid indicate introgression may contribute evolutionary rescue ranges.

Language: Английский

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Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences

Nature Ecology & Evolution, Journal Year: 2024, Volume and Issue: 8(3), P. 519 - 535

Published: Jan. 12, 2024

Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and often assumed to be causally associated with organismal innovations radiations. The 2R hypothesis suggests two WGD events (1R 2R) occurred during early vertebrate evolution. However, the timing of relative divergence gnathostomes (jawed vertebrates) cyclostomes (jawless hagfishes lampreys) unresolved whether these underlie phenotypic diversification remains elusive. Here we present inshore hagfish, Eptatretus burgeri. Through comparative analysis lamprey gnathostome genomes, reconstruct in cyclostome evolution, leveraging insights into ancestral genome. Genome-wide synteny phylogenetic analyses support scenario which 1R stem-lineage Cambrian, stem-lineage, maximally late Cambrian-earliest Ordovician, after its from cyclostomes. We find stem-cyclostomes experienced an additional independent triplication. Functional genomic morphospace demonstrate generally contribute developmental evolution similar changes regulatory both groups. appreciable morphological only but not lineage, calling question general expectation WGDs lead leaps bodyplan complexity.

Language: Английский

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A lethal mitonuclear incompatibility in complex I of natural hybrids

Nature, Journal Year: 2024, Volume and Issue: 626(7997), P. 119 - 127

Published: Jan. 10, 2024

The evolution of reproductive barriers is the first step in formation new species and can help us understand diversification life on Earth. These often take form hybrid incompatibilities, which alleles derived from two different no longer interact properly hybrids

Language: Английский

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Drainage divide migration and implications for climate and biodiversity

Nature Reviews Earth & Environment, Journal Year: 2024, Volume and Issue: 5(3), P. 177 - 192

Published: Feb. 1, 2024

Language: Английский

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