bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 10, 2023
The arginine dihydrolase pathway (
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Language: Английский
Citations
255
Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(6), P. 820 - 836
Published: June 1, 2024
Microbial communities that colonize the human gastrointestinal (GI) tract defend against pathogens through a mechanism known as colonization resistance (CR). Advances in technologies such next-generation sequencing, gnotobiotic mouse models, and bacterial cultivation have enhanced our understanding of underlying mechanisms intricate microbial interactions involved CR. Rather than being attributed to specific clades, CR is now understood arise from dynamic interplay between microbes host shaped by metabolic, immune, environmental factors. This evolving perspective underscores significance contextual factors, encompassing microbiome composition conditions, determining review highlights recent research has shifted its focus toward elucidating how these factors interact either promote or impede enteric infections. It further discusses future directions unravel complex relationship host, microbiota, determinants safeguarding GI infections health.
Language: Английский
Citations
16
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 335, P. 122113 - 122113
Published: April 1, 2024
Language: Английский
Citations
15
Nature, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
1
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Aug. 28, 2024
The human gut pathogen Clostridioides difficile displays substantial inter-strain genetic variability and confronts a changeable nutrient landscape in the gut. We examined how microbiota inter-species interactions influence growth toxin production of various C. strains across different environments. Negative influencing are prevalent an environment containing single highly accessible resource sparse difficile-preferred carbohydrates. significant community-context dependent variation does not trend with growth-mediated interactions. exhibit differences Clostridium scindens ability to compete for proline. Further, shows transcriptional profiles co-culture or hiranonis. exhibits massive alterations metabolism other cellular processes hiranonis, reflecting their similar metabolic niches. hiranonis uniquely inhibits diverse environments robustly ameliorates disease severity mice. In sum, understanding impact strain on could help improve effectiveness anti-C. strategies.
Language: Английский
Citations
7
Water Research, Journal Year: 2024, Volume and Issue: 262, P. 122053 - 122053
Published: July 5, 2024
Biofiltration is a low-cost, low-energy technology that employs biologically activated bed of porous medium to reduce the biodegradable fraction dissolved organic matter (DOM) pool in source water, resulting production drinking water. Microbial communities at different depths within biofilter play crucial roles degradation and removal carbon (DOC), ultimately impacting its performance. However, relationships between composition microbial inhabiting their utilisation various DOC fractions remain poorly understood. To address this knowledge gap, we conducted an experimental study where from upper (i.e., top 10 cm) lower bottom sections 30-cm long laboratory-scale were recovered. These then individually incubated for days using same water as influent. Our revealed community exhibited diversity yet had co-occurrence network with higher degree interconnections among members compared community. Moreover, established direct correlation structure ability utilise DOM compounds pool. Interestingly, although only 20 % total cell abundance beginning incubation, it utilised hence removed approximately 60 more than While both rapidly labile fractions, such low-molecular-weight neutrals, refractory like high-molecular-weight humic substances average molecular weight ca. 1451 g/mol, was exclusive By employing techniques capture flow cytometry 16S rRNA amplicon sequencing) considering complexities LCOCD), our provides novel insights into how could influence microbial-mediated processes engineering significance production. Finally, findings offer opportunity improve performances via interventions shape compositions enhance DOM, most notably classically humified compound groups.
Language: Английский
Citations
6
Current Opinion in Systems Biology, Journal Year: 2023, Volume and Issue: 36, P. 100479 - 100479
Published: Sept. 15, 2023
Language: Английский
Citations
10
Cell Reports, Journal Year: 2023, Volume and Issue: 43(1), P. 113519 - 113519
Published: Dec. 23, 2023
The critical role of the intestinal microbiota in human health and disease is well recognized. Nevertheless, there are still large gaps our understanding functions mechanisms encoded genomes most members gut microbiota. Genome-scale libraries transposon mutants a powerful tool to help us address this gap. Recent advances barcoded mutagenesis have dramatically lowered cost mutant fitness determination hundreds vitro vivo experimental conditions. In an accompanying review, we discuss recent caveats for construction pooled arrayed commensals. how these can be used across wide range applications, technical aspects involved, expectations such screens.
Language: Английский
Citations
10
Microbiological Research, Journal Year: 2025, Volume and Issue: 292, P. 128046 - 128046
Published: Jan. 2, 2025
Language: Английский
Citations
0
Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115583 - 115583
Published: Jan. 1, 2025
Language: Английский
Citations
0