Amygdala-derived-EEG-fMRI-pattern neurofeedback for the treatment of chronic post-traumatic stress disorder. A prospective, multicenter, multinational study evaluating clinical efficacy

Psychiatry Research, Journal Year: 2024, Volume and Issue: 333, P. 115711 - 115711

Published: Jan. 8, 2024

We conducted a prospective, single arm, multisite, multinational, open label trial assessing the safety and efficacy of novel amygdala derived neurofeedback treatment, designated Amygdala-Derived-EFP, for chronic PTSD. Participants, including veterans civilians, underwent screening, training, 15 sessions over 8 weeks and; baseline, termination (8 weeks) 3 month post treatment assessments with validated measures. The primary endpoint was more than 50% participants demonstrating Minimally Clinically Important Difference (MCID) defined as 6-point reduction, on Clinician Administered PTSD Scale (CAPS-5) total score at months. Secondary measures included PCL-5, ERQ, PHQ-9, CGI. Statistical analyses were performed using SAS®V9.4. met, CAPS-5 MCID response rate 66.7%. average reduction in scores follow up 13.5 points, twice MCID. Changes from baseline CAPS-5, PHQ-9 follow-up demonstrated statistically significant improvements effect sizes ranging 0.46 to 1.07. Adverse events mild resolved after treatment. This study builds prior research similar outcomes amygdala-derived neurofeedback. Positive attributes this therapy include monitoring by non-physician personnel, affordability, accessibility, tolerability.

Language: Английский

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The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal–amygdala neural circuitry during positive‐social emotion regulation

Human Brain Mapping, Journal Year: 2020, Volume and Issue: 41(11), P. 3100 - 3118

Published: April 20, 2020

Abstract Positive‐social emotions mediate one's cognitive performance, mood, well‐being, and social bonds, represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive in situations is associated with increased top‐down signals stem from prefrontal cortices (PFC) which modulate bottom‐up emotional responses amygdala. However, it remains unclear if positive‐social emotion amygdala occurs directly through dorsomedial PFC (dmPFC) or indirectly linking bilateral dmPFC via subgenual anterior cingulate cortex (sgACC), an area typically serves as gatekeeper between networks. We performed functional MRI (fMRI) experiments without effortful to demonstrate architecture network involving amygdala, dmPFC, sgACC. found was increase connectivity on both direct indirect connections Conversely, we processes regulation modulation by sgACC also more anxious individuals greater tendency suppress intrusive thoughts, were likely display decreased activity stronger strength onto left during upregulation. Analyzed brain suggests general role control sheds light neurobiological informed treatment interventions.

Language: Английский

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Improved emotion regulation after neurofeedback: A single-arm trial in patients with borderline personality disorder

NeuroImage Clinical, Journal Year: 2019, Volume and Issue: 24, P. 102032 - 102032

Published: Jan. 1, 2019

Real-time functional magnetic resonance imaging (fMRI) neurofeedback training of amygdala hemodynamic activity directly targets a neurobiological mechanism, which contributes to emotion regulation problems in borderline personality disorder (BPD). However, it remains unknown outcome measures can assess changes and affective instability, associated with downregulation clinical trial. The current study addresses this question. Twenty-four female patients DSM-IV BPD diagnosis underwent four runs neurofeedback. Before after the training, as well at six-weeks follow-up assessment, participants completed dysregulation instability diverse levels analysis (verbal report, interview, ecological momentary emotion-modulated startle, heart rate variability, fMRI). Participants were able downregulate their blood oxygen-dependent (BOLD) response There was decrease symptoms assessed Zanarini rating scale for (ZAN-BPD) startle negative pictures training. Further explorative analyses suggest that indicated less seen by lower hour-to-hour variability affect inner tension daily life. If replicated an independent study, our results imply several systems levels, including behavior verbal report. Conclusions are limited due lack control group. A randomized controlled trial (RCT) will be needed confirm effectiveness

Language: Английский

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The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review

Neural Plasticity, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 31

Published: Feb. 4, 2021

This article is aimed at showing the current level of evidence for usage biofeedback and neurofeedback to treat depression along with a detailed review studies in field discussion rationale utilizing each protocol. La Vaque et al. criteria endorsed by Association Applied Psychophysiology Biofeedback International Society Neuroregulation & Research were accepted as means study evaluation. Heart rate variability (HRV) was found be moderately supportable treatment MDD while outcome measure subjective questionnaire like Beck Depression Inventory (level 3/5, “probably efficacious”). Electroencephalographic (EEG) protocols, namely, alpha-theta, alpha, sensorimotor rhythm upregulation, all qualify 2/5, “possibly efficacious.” Frontal alpha asymmetry protocol also received limited effect Finally, two most influential real-time functional magnetic resonance imaging (rt-fMRI) protocols targeting amygdala frontal cortices both demonstrate some effectiveness, though lack replications Thus, specifically supported existing (all fit The greatest complication preventing certain from reaching higher levels relatively high number uncontrolled an absence accurate arising heterogeneity details, course lengths, measures improvement, control conditions, sample characteristics.

Language: Английский

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Real-time fMRI neurofeedback as a new treatment for psychiatric disorders: A meta-analysis

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2022, Volume and Issue: 119, P. 110605 - 110605

Published: July 16, 2022

Language: Английский

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Simultaneous real-time EEG-fMRI neurofeedback: A systematic review

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 31, 2023

Neurofeedback (NF) is a biofeedback technique that teaches individuals self-control of brain functions by measuring activations and providing an online feedback signal to modify emotional, cognitive, behavioral functions. NF approaches typically rely on single modality, such as electroencephalography (EEG-NF) or imaging technique, functional magnetic resonance (fMRI-NF). The introduction simultaneous EEG-fMRI tools has opened up the possibility combining high temporal resolution EEG with spatial fMRI, thereby increasing accuracy NF. However, only few studies have actively combined both techniques. In this study, we conducted systematic review EEG-fMRI-NF (N = 17) identify potential effectiveness non-invasive treatment for neurological conditions. revealed lack homogeneity among studies, including sample sizes, acquisition methods in terms simultaneity two procedures (unimodal EEG-NF fMRI-NF), therapeutic targets field, number sessions. Indeed, because most are based session NF, it difficult draw any conclusions regarding efficacy Therefore, further research needed fully understand non-clinical clinical EEG-fMRI-NF.

Language: Английский

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Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 25, 2023

Abstract Hyperactivation of amygdala is a neural marker for post-traumatic stress disorder (PTSD) and improvement in control over activity has been associated with treatment success PTSD. In this randomized, double-blind clinical trial we evaluated the efficacy real-time fMRI neurofeedback intervention designed to train following trauma recall. Twenty-five patients PTSD completed three sessions training which they attempted downregulate feedback signal after exposure personalized scripts. For subjects active experimental group ( N = 14), was from functionally localized region their 11), yoked-sham provided. Changes symptoms served as primary secondary outcome measurements, respectively. We found significantly greater improvements than 30-days intervention. Both groups showed symptom scores, however reduction not group. Our finding suggests potential application treatment. Thus, further development treatment, including evaluation larger samples, warranted.

Language: Английский

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Review on the Use of Brain Computer Interface Rehabilitation Methods for Treating Mental and Neurological Conditions

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(7)

Published: July 5, 2024

This review provides a comprehensive examination of recent developments in both neurofeedback and brain-computer interface (BCI) within the medical field rehabilitation. By analyzing comparing results obtained with various tools techniques, we aim to offer systematic understanding BCI applications concerning different modalities input data utilized. Our primary objective is address existing gap area meta-reviews, which more outlook on field, allowing for assessment current landscape scope BCI. main methodologies include meta-analysis, search queries employing relevant keywords, network-based approach. We are dedicated delivering an unbiased evaluation studies, elucidating vectors research development this field. encompasses diverse range applications, incorporating use interfaces rehabilitation treatment diagnoses, including those related affective spectrum disorders. encompassing wide variety cases, perspective utilization treatments across contexts. The structured organized presentation information, complemented by accompanying visualizations diagrams, renders valuable resource scientists researchers engaged domains biofeedback interfaces.

Language: Английский

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Volitional limbic neuromodulation exerts a beneficial clinical effect on Fibromyalgia

NeuroImage, Journal Year: 2018, Volume and Issue: 186, P. 758 - 770

Published: Nov. 5, 2018

Language: Английский

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Mental Imagery and Brain Regulation—New Links Between Psychotherapy and Neuroscience

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: Oct. 30, 2019

Mental imagery is a promising tool and mechanism of psychological interventions, particularly for mood anxiety disorders. In parallel developments, neuromodulation techniques have shown promise as add-on therapies in psychiatry, non-invasive brain stimulation depression. However, these not yet been combined systematic manner. One novel technology that may be able to achieve this neurofeedback, which entails the self-regulation activation specific areas or networks (or self-modulation distributed patterns) by patients themselves, through real-time feedback (for example from functional magnetic resonance imaging). key mechanisms learn such mental imagery. Here we will first review main approaches psychotherapy implicated networks. We then discuss how can targeted with (non-invasive invasive neurofeedback). clinical evidence neurofeedback possible ways enhancing it combination focus on depression, disorders addiction. The overarching aim perspective paper open debate new developing neuro-psychotherapies.

Language: Английский

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