Sleep Genetics and Cognitive Changes over Time: The Moderating Effect of Age and the Role of Brain DOI Open Access
Angeliki Tsapanou, Seonjoo Lee, Silvia Chapman

et al.

Genes, Journal Year: 2024, Volume and Issue: 16(1), P. 21 - 21

Published: Dec. 26, 2024

Sleep plays a crucial role in cognitive performance and changes aging. In the current study, we investigated of sleep duration genetics over time moderating effect age. Participants were drawn from Reference Abilities Neural Network Cognitive Reserve studies Columbia University. Each participant underwent an evaluation function extensive neuropsychological assessment. Published GWAS summary statistics polygenic score for (Sleep PGI) used to derive PGI our study. We examined whether this is associated with 5-year follow-up if age moderates effect. Analysis was performed after first being adjusted group (young: 20-44; middle: 45-64; old: 65-80), sex, education, four principal components, intracranial volume (ICV), mean cortical thickness, total gray matter volume. included ICV, volumes as time-varying covariates. further interactions PCs. A 96 white-only participants included, aged 24 78 years old. fully model, age-specific analysis showed that younger individuals, higher lower rates decline speed processing. Genetic variants significantly influence processing, playing critical role, above brain morphometry. genetic predisposition longer can work protective factor against processing young adults.

Language: Английский

To nap or not? Evidence from a meta-analysis of cohort studies of habitual daytime napping and health outcomes DOI

Ying-Bo Yang,

Yongbo Zheng, Jie Sun

et al.

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 78, P. 101989 - 101989

Published: Aug. 8, 2024

Language: Английский

Citations

6
Human genetic variation determines 24-hour rhythmic gene expression and disease risk DOI Creative Commons
Dongyin Guan, Runsheng Chen, Panpan Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these increases the risks multiple diseases. The known have a genetic basis formed by core clock genes, but how individual variation shapes oscillating transcriptome and contributes human chronophysiology disease risk is largely unknown. Here, we mapped interactions between temporal gene expression genotype identify quantitative trait loci (QTLs) contributing rhythmic expression. These newly identified QTLs were termed as (rhyQTLs), which determine previously unappreciated genes in subpopulations with specific genotypes. Functionally, rhyQTLs their associated contribute extensively chronophysiological processes, including bile acid lipid metabolism. identification sheds light on mechanisms rhythmicity, offers mechanistic insights into variations risk, enables precision chronotherapeutic approaches for patients.

Language: Английский

Citations

0
Whole exome sequencing identified six novel genes for depressive symptoms DOI

Ze-Yu Li,

Chen-Jie Fei,

Rui-Ying Yin

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Language: Английский

Citations

0
Siesta behavior and genetics interact to influence obesity risk DOI Creative Commons
María Rodríguez‐Martín, Diego Salmerón, Hassan S. Dashti

et al.

Obesity, Journal Year: 2024, Volume and Issue: 33(1), P. 164 - 176

Published: Dec. 23, 2024

Abstract Objective In this cross‐sectional study, we aim to investigate the interactions between obesity, siesta behavior, and genetic propensity for in a Mediterranean population, whom is deeply rooted. Methods We applied previously generated Siesta‐Polygenic Score (PGS) ONTIME study ( n = 1278). Siesta other lifestyle behaviors were characterized using questionnaires. further determined obesity grade. Secondarily, measured weight loss during treatment as well long‐term weight‐loss maintenance. Logistic regression analyses performed address our aim. Results A total of 42.4% population usually took siesta. significant influence on was found, with higher predisposition linked taking more frequently (odds ratio [OR] 1.17, 95% CI: 1.03–1.32; p 0.015). Participants showed poorer dietary habits < 0.05). Among individuals high siesta, found that those who take have lower odds having 0.038) compared do not. Similarly, exploratory analysis, among success 0.007) Conclusions Considering ongoing debate regarding whether beneficial or detrimental, findings suggest individual might association health. image

Language: Английский

Citations

0
Association between sleep traits and epilepsy risk: a two-sample Mendelian randomization study DOI Creative Commons
Xun Li,

Wei Yue

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Background Sleep and epilepsy have been reported to a possible interaction. This study intended assess the causal relationship between sleep traits risk through two-sample Mendelian randomization (MR) study. Methods Exposure- [sleep traits: getting up in morning, sleeplessness/insomnia, duration, nap during day, morning/evening person (chronotype), daytime dozing/sleeping (narcolepsy).] outcome- [Europeans: epilepsy, focal generalized epilepsy; East Asians: epilepsy] related single-nucleotide polymorphisms (SNPs) from publicly available genome-wide association studies (GWAS) databases were used as instrumental variables for analysis. The main analyses inverse variance weighted (IVW) derive causality estimates, which expressed odds ratio (OR) 95% confidence interval (CI). Sensitivity performed reliability of results. Results For Europeans, genetically predicted morning decreased (OR = 0.354, 95%CI: 0.212–0.589) 0.256, 0.101–0.651), whereas evening (chronotype) increased 1.371, 1.082–1.739) 1.618, 1.061–2.467). No significant associations found (narcolepsy) Europeans. Asians, only sleeplessness/insomnia was increase 1.381, 1.039–1.837). Conclusion There Asians.

Language: Английский

Citations

0
Sleep Genetics and Cognitive Changes over Time: The Moderating Effect of Age and the Role of Brain DOI Open Access
Angeliki Tsapanou, Seonjoo Lee, Silvia Chapman

et al.

Genes, Journal Year: 2024, Volume and Issue: 16(1), P. 21 - 21

Published: Dec. 26, 2024

Sleep plays a crucial role in cognitive performance and changes aging. In the current study, we investigated of sleep duration genetics over time moderating effect age. Participants were drawn from Reference Abilities Neural Network Cognitive Reserve studies Columbia University. Each participant underwent an evaluation function extensive neuropsychological assessment. Published GWAS summary statistics polygenic score for (Sleep PGI) used to derive PGI our study. We examined whether this is associated with 5-year follow-up if age moderates effect. Analysis was performed after first being adjusted group (young: 20-44; middle: 45-64; old: 65-80), sex, education, four principal components, intracranial volume (ICV), mean cortical thickness, total gray matter volume. included ICV, volumes as time-varying covariates. further interactions PCs. A 96 white-only participants included, aged 24 78 years old. fully model, age-specific analysis showed that younger individuals, higher lower rates decline speed processing. Genetic variants significantly influence processing, playing critical role, above brain morphometry. genetic predisposition longer can work protective factor against processing young adults.

Language: Английский

Citations

0