A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Feb. 11, 2020

Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated neurodegenerative diseases. While genetic environmental factors influence amyloid formation, molecular triggers and/or facilitators not well defined. Growing evidence suggests that non-identical proteins may accelerate reciprocal aggregation in prion-like fashion. humans encode ~30 amyloidogenic proteins, the gut microbiome also produces functional amyloids. For example, curli cell surface abundantly expressed by certain bacteria. In mice overexpressing human α-synuclein (αSyn), we reveal colonization curli-producing Escherichia coli promotes αSyn pathology brain. Curli expression is required for E. exacerbate αSyn-induced behavioral deficits, including intestinal motor impairments. Purified subunits biochemical assays, while oral treatment gut-restricted inhibitor prevents curli-mediated acceleration abnormalities. We propose exposure microbial amyloids gastrointestinal tract disease

Language: Английский

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Considerations for the Use of Phage Therapy in Clinical Practice

Antimicrobial Agents and Chemotherapy, Journal Year: 2022, Volume and Issue: 66(3)

Published: Jan. 18, 2022

Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct conventional antimicrobials. Expanded access compassionate use cases risen exponentially but varied widely approach, methodology, clinical situations which might be considered, dosing, route of administration, outcomes.

Language: Английский

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Emergence of three-dimensional order and structure in growing biofilms

Nature Physics, Journal Year: 2018, Volume and Issue: 15(3), P. 251 - 256

Published: Nov. 16, 2018

Language: Английский

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Viruses in soil: Nano-scale undead drivers of microbial life, biogeochemical turnover and ecosystem functions

Soil Biology and Biochemistry, Journal Year: 2018, Volume and Issue: 127, P. 305 - 317

Published: Oct. 3, 2018

Language: Английский

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(Ph)ighting Phages: How Bacteria Resist Their Parasites

Cell Host & Microbe, Journal Year: 2019, Volume and Issue: 25(2), P. 184 - 194

Published: Feb. 1, 2019

Language: Английский

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Bacterial defences: mechanisms, evolution and antimicrobial resistance

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(8), P. 519 - 534

Published: April 24, 2023

Language: Английский

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Mixed-species biofilms in the food industry: Current knowledge and novel control strategies

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(13), P. 2277 - 2293

Published: July 1, 2019

Attachment of microorganisms to food contact surfaces and the subsequent formation biofilms may cause equipment damage, spoilage even diseases. Mixed-species are ubiquitous in industry they generally exhibit higher resistance disinfectants antimicrobials compared single-species biofilms. The physiology metabolic activity mixed-species however rather complicated study, despite targeted research efforts, potential role is still unexplored. In this review, we summarize recent studies context bacterial social interactions biofilms, disinfectants, detection methods, novel strategies control for enhanced safety quality.

Language: Английский

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Decorated bacteria and the application in drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114443 - 114443

Published: July 8, 2022

Language: Английский

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Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

Cell, Journal Year: 2023, Volume and Issue: 186(12), P. 2690 - 2704.e20

Published: June 1, 2023

Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for pathogen Vibrio cholerae, biofilm not only protective trait but also an aggressive to collectively predate different cells. We find V. cholerae forms biofilms on eukaryotic cell surface using extracellular matrix comprising primarily mannose-sensitive hemagglutinin pili, toxin-coregulated secreted colonization factor TcpF, which differs from composition other surfaces. These encase cells establish high local concentration hemolysin kill before disperse in c-di-GMP-dependent manner. Together, these results uncover how bacteria employ multicellular strategy invert typical relationship between hunters hunted.

Language: Английский

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Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation

Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

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