Maternal Vertical Transmission Affecting Early-life Microbiota Development

Trends in Microbiology, Journal Year: 2019, Volume and Issue: 28(1), P. 28 - 45

Published: Sept. 3, 2019

Language: Английский

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Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

Antibiotics in childhood have been linked with diseases including asthma, juvenile arthritis, type 1 diabetes, Crohn's disease and mental illness. The underlying mechanisms are thought related to dysbiosis of the gut microbiome. We conducted a systematic review association between antibiotics disruption pediatric Searches used MEDLINE, EMBASE Web Science. Eligible studies: microbiome dysbiosis; children 0-18 years; molecular techniques assessment; outcomes richness, diversity or composition. Quality assessed by Newcastle-Ottawa Scale Cochrane Risk Bias Tool. Meta-analysis where possible. A total 4,668 publications identified: 12 final analysis (5 randomized controlled trials (RCTs), 5 cohort studies, 2 cross-sectional studies). Microbiome richness was measured 3 species 6, composition 10. evidence good fair. studies found significant reduction richness. Macrolide exposure associated reduced for twice as long penicillin. Significant reductions were seen Bifidobacteria studies) Lactobacillus (2 studies), increases Proteobacteria such E. coli (4 meta-analysis RCTs effect macrolide (azithromycin) on alpha-diversity (Shannon index: mean difference -0.86 (95% CI -1.59, -0.13). Antibiotic changes bacterial abundance. potential should be taken into account when prescribing children.Systematic registration number: CRD42018094188.

Language: Английский

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Selection for antimicrobial resistance is reduced when embedded in a natural microbial community

The ISME Journal, Journal Year: 2019, Volume and Issue: 13(12), P. 2927 - 2937

Published: Aug. 5, 2019

Abstract Antibiotic resistance has emerged as one of the most pressing, global threats to public health. In single-species experiments selection for antibiotic occurs at very low concentrations. However, it is unclear how far these findings can be extrapolated natural environments, where species are embedded within complex communities. We competed isogenic strains Escherichia coli, differing exclusively in a single chromosomal determinant, presence and absence pig faecal microbial community across gradient concentration two relevant antibiotics: gentamicin kanamycin. show that minimal selective was increased by more than order magnitude both antibiotics when community. identified general mechanisms were responsible increase concentration: an cost protective effect susceptible phenotype. These have implications our understanding evolution resistance, inform future risk assessment efforts on

Language: Английский

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Antibiotic resistance in aquaculture and aquatic organisms: a review of current nanotechnology applications for sustainable management

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(46), P. 69241 - 69274

Published: Aug. 15, 2022

Language: Английский

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Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(7), P. 431 - 443

Published: Jan. 31, 2022

Language: Английский

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