Current Opinion in Microbiology,
Journal Year:
2023,
Volume and Issue:
74, P. 102328 - 102328
Published: May 26, 2023
Antimicrobial
susceptibility
testing
is
the
cornerstone
of
antibiotic
treatments.
Yet,
active
drugs
are
frequently
unsuccessful
in
vivo
and
most
clinical
trials
investigating
antibiotics
fail.
So
far,
bacterial
survival
strategies,
other
than
drug
resistance,
have
been
largely
ignored.
As
such,
tolerance
persisters,
allowing
populations
to
survive
during
treatments,
could
fill
a
gap
testing.
Therefore,
it
remains
critical
establish
robust
scalable
viability
measures
define
relevance
survivors
across
various
infections.
If
successful,
these
tools
improve
design
development
prevent
formation
or
target
survivors,
ultimately
reduce
treatment
failures
curb
resistance
evolution.
Environment International,
Journal Year:
2023,
Volume and Issue:
178, P. 108126 - 108126
Published: Aug. 1, 2023
In
recent
years,
the
excessive
of
antibiotics
in
livestock
and
poultry
husbandry,
stemming
from
extensive
industry
experience,
has
resulted
accumulation
residual
antibiotic
resistance
genes
(ARGs)
manure.
Composting,
as
a
crucial
approach
for
utilization
manure
resources,
potential
to
reduce
levels
ARGs
manure,
although
complete
elimination
is
challenging.
Previous
studies
have
primarily
focused
on
diversity
abundance
compost
or
solely
examined
correlation
between
their
carriers,
potentially
leading
misjudgment
actual
risk
associated
with
compost.
To
address
this
gap,
study
investigated
transfer
co-occurrence
opportunistic
pathogenic
bacteria
by
extensively
analyzing
metagenomic
sequencing
data
worldwide.
The
results
demonstrated
that
was
significantly
lower
than
suggesting
composting
effectively
reduces
ARGs.
Further
analysis
showed
microbes
shifted
life
history
strategy
due
pressure
formed
metabolic
interactions
dominated
antibiotic-resistant
microbes,
increasing
ARG
dissemination
frequency.
Therefore,
husbandry
practice
without
addition
recommended
control
evolution,
dissemination,
abatement
both
at
source
throughout
processing.
Cell Host & Microbe,
Journal Year:
2024,
Volume and Issue:
32(6), P. 786 - 793
Published: June 1, 2024
Survival
strategies
of
human-associated
microbes
to
drug
exposure
have
been
mainly
studied
in
the
context
bona
fide
pathogens
exposed
antibiotics.
Less
well
understood
are
survival
non-pathogenic
and
host-associated
commensal
communities
variety
drugs
xenobiotics
which
humans
exposed.
The
lifestyle
microbial
commensals
within
complex
offers
a
ways
adapt
different
drug-induced
stresses.
Here,
we
review
responses
employed
by
gut
when
drugs-antibiotics
non-antibiotics-at
individual
community
level.
We
also
discuss
factors
influencing
recovery
establishment
new
structure
following
exposure.
These
key
stability
resilience
microbiome,
ultimately
overall
health
well-being
host.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 31, 2024
Biofilm
formation
enhances
bacterial
survival
and
antibiotic
tolerance,
but
the
underlying
mechanisms
are
incompletely
understood.
Here,
we
show
that
biofilm
growth
is
accompanied
by
a
reduction
in
energy
metabolism
membrane
potential,
together
with
metabolic
exchanges
between
inner
outer
regions
biofilms.
More
specifically,
nutrient-starved
cells
interior
supply
amino
acids
to
periphery,
while
peripheral
experience
decrease
potential
provide
fatty
cells.
Fatty
facilitate
repair
of
starvation-induced
damage
enhance
their
presence
antibiotics.
Thus,
contribute
tolerance
within
biofilm.
tolerance.
authors
biofilms
interior.
Science,
Journal Year:
2024,
Volume and Issue:
385(6716)
Published: Sept. 26, 2024
Harnessing
the
microbiome
to
benefit
human
health
requires
an
initial
step
in
determining
identity
and
function
of
causative
microorganisms
that
affect
specific
host
physiological
functions.
We
show
a
functional
screen
bacterial
microbiota
from
mice
with
low
intestinal
immunoglobulin
A
(IgA)
levels;
we
identified
Gram-negative
bacterium,
proposed
as
Tomasiella
immunophila
,
induces
degrades
IgA
mouse
intestine.
Mice
harboring
T.
are
susceptible
infections
poor
mucosal
repair.
is
auxotrophic
for
cell
wall
amino
sugar
N-acetylmuramic
acid.
It
delivers
immunoglobulin-degrading
proteases
into
outer
membrane
vesicles
preferentially
degrade
rodent
antibodies
kappa
but
not
lambda
light
chains.
This
work
indicates
role
symbionts
immunodeficiency,
which
might
be
applicable
disease.
Current Opinion in Microbiology,
Journal Year:
2023,
Volume and Issue:
74, P. 102328 - 102328
Published: May 26, 2023
Antimicrobial
susceptibility
testing
is
the
cornerstone
of
antibiotic
treatments.
Yet,
active
drugs
are
frequently
unsuccessful
in
vivo
and
most
clinical
trials
investigating
antibiotics
fail.
So
far,
bacterial
survival
strategies,
other
than
drug
resistance,
have
been
largely
ignored.
As
such,
tolerance
persisters,
allowing
populations
to
survive
during
treatments,
could
fill
a
gap
testing.
Therefore,
it
remains
critical
establish
robust
scalable
viability
measures
define
relevance
survivors
across
various
infections.
If
successful,
these
tools
improve
design
development
prevent
formation
or
target
survivors,
ultimately
reduce
treatment
failures
curb
resistance
evolution.
