The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics DOI Creative Commons

Yucui Zhao,

Shixiao Zhu,

Yingling Dong

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1643 - 1643

Published: Dec. 21, 2024

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) characterized by chronic or recurrent symptoms without organic changes, and it also common of gut–brain interaction (DGBIs).. The IBS not only affect the quality life for individual patients but place significant burden on global healthcare systems. lack established universally applicable biomarkers IBS, along with substantial variability in progression, presents challenges developing effective clinical treatments. In recent years, preclinical studies have linked pathogenesis to alterations composition function intestinal microbiota. Within complex microbial community gut, intricate metabolic spatial interactions occur among its members between microbes their hosts. Amid multifaceted pathophysiology role microenvironment factors symptom development has become more apparent. This review aims delve into changes structure gut microbiome individuals IBS. It explores how diet-mediated byproducts play regulating influencing “brain-gut” axis, barrier function, immune responses, more. By doing so, this seeks lay theoretical foundation advancing therapeutics

Language: Английский

Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis DOI
Ping Chen,

Fanyang Chen,

Tao Hou

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138698 - 138698

Published: Dec. 11, 2024

Language: Английский

Citations

0
The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics DOI Creative Commons

Yucui Zhao,

Shixiao Zhu,

Yingling Dong

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1643 - 1643

Published: Dec. 21, 2024

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) characterized by chronic or recurrent symptoms without organic changes, and it also common of gut–brain interaction (DGBIs).. The IBS not only affect the quality life for individual patients but place significant burden on global healthcare systems. lack established universally applicable biomarkers IBS, along with substantial variability in progression, presents challenges developing effective clinical treatments. In recent years, preclinical studies have linked pathogenesis to alterations composition function intestinal microbiota. Within complex microbial community gut, intricate metabolic spatial interactions occur among its members between microbes their hosts. Amid multifaceted pathophysiology role microenvironment factors symptom development has become more apparent. This review aims delve into changes structure gut microbiome individuals IBS. It explores how diet-mediated byproducts play regulating influencing “brain-gut” axis, barrier function, immune responses, more. By doing so, this seeks lay theoretical foundation advancing therapeutics

Language: Английский

Citations

0