Pt-Induced Sublattice Distortion Facilitates Enzyme Cascade Reactions for Eradicating Intracellularly Methicillin-Resistant Staphylococcus aureus and Enhancing Diabetic Wound Healing
Xiaoning Hou,
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Hongsu Wang,
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Xinyu Yao
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et al.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Metal
oxide
nanozymes
hold
significant
potential
in
combating
bacterial
infections;
however,
their
ordered
crystal
structures
limit
the
enhancement
of
catalytic
activity,
posing
challenges
addressing
clinical
needs
for
eliminating
intracellularly
colonized
bacteria.
Here,
we
report
development
an
integrated
diagnostic-therapeutic
microneedle
patch
incorporates
Res@PtZ-Z
nanozyme
hybrid.
consists
a
ZIF
shell
loaded
with
natural
compound
resveratrol
(Res),
encapsulating
Pt-doped
zinc
(ZnO)
core
(PtZ).
The
Res
component
modulates
charge
distribution
on
and
attenuates
virulence,
thereby
promoting
uptake
by
host
cells.
PtZ
core,
doped
Pt4+
to
induce
sublattice
distortion
ZnO,
exhibits
oxidase-like,
peroxidase-like,
catalase-like
activities.
Under
intracellular
hypoxic
conditions,
cascade
these
enzyme-like
activities
ensures
sustained
generation
reactive
oxygen
species
(ROS),
enabling
robust
antibacterial
effects.
Additionally,
enables
real-time
infection
monitoring
oxidizing
3,3',5,5'-tetramethylbenzidine
(TMB)
substrate
produce
distinct
colorimetric
response.
This
approach
addresses
both
methicillin-resistant
Staphylococcus
aureus
(MRSA)
invasion
persistence,
contributing
improved
management
wound
healing.
Language: Английский
Regulatory Mechanisms of Two-Component Systems in Vibrio cholerae: Enhancing Pathogenicity and Environmental Adaptation
Microbiological Research,
Journal Year:
2025,
Volume and Issue:
298, P. 128198 - 128198
Published: May 1, 2025
Language: Английский
MgFe-LDHs/Vallisneria natans combined system for simultaneous elimination of endogenous N and P pollution in eutrophic water: Performance, synergetic mechanism, and metagenomics analysis
Zihao Hu,
No information about this author
Zeyu Li,
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Yin Xu
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et al.
Environmental Research,
Journal Year:
2025,
Volume and Issue:
279, P. 121798 - 121798
Published: May 9, 2025
Language: Английский
The Dielectrophoretic Interactions of Curved Particles in a DC Electric Field
Zhiwei Huang,
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Tong Zhang,
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Feng Jing
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et al.
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(5), P. 596 - 596
Published: May 20, 2025
In
practical
dielectrophoretic
cell
interaction
experiments,
cells
do
not
always
exhibit
circular
or
rod-like
shapes,
making
the
study
of
interactions
among
irregularly
shaped
particles
significant
importance.
We
established
a
mathematical
model
for
curved
to
analyze
their
mutual
interactions,
incorporating
particle
deformability
by
varying
shear
modulus,
and
employed
arbitrary
Lagrangian–Eulerian
method
describe
motion
deformation.
The
results
demonstrate
that
under
influence
direct
current
electric
field,
undergo
rotation,
deformation,
attraction
due
dielectrophoresis,
eventually
forming
stable
alignment
parallel
applied
field.
Adjusting
field
strength
effectively
modulates
intensity
movement
velocity
between
particles.
This
elucidates
fundamental
principles
governing
deformable
in
DC
fields,
providing
theoretical
guidance
manipulation
experiments
involving
biological
cells,
metallic
particles,
other
entities
fields.
Language: Английский