Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 138 - 174

Published: Feb. 5, 2025

Language: Английский

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Efficient oral insulin delivery with sustained release by folate-conjugated metal-organic framework nanoparticles

Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101948 - 101948

Published: Jan. 14, 2025

Language: Английский

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Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 22, 2025

Diabetes represents a global health crisis that necessitates advancements in prevention, treatment, and management. Beyond glucose regulation, addressing weight management associated complications is imperative. This study introduces an oral nanoparticle formulation designed to simultaneously control blood glucose, obesity, metabolic dysfunction. These nanoparticles, based on poly (zwitterion-cholic acid), incorporate polyzwitterion component enhance permeation through the mucus layer prolong drug residence. Furthermore, bile acid polymers not only regulate lipid metabolism but also ameliorate obesity-associated inflammation adipose liver tissues. In vivo experiments demonstrated significant hypoglycemic effects healthy, type I diabetic, II diabetic mice. Notably, nanocarriers significantly reduced body gain, ameliorated tissues, modulated of db/db Our elucidates comprehensive strategy for glycemic diabetes-related complications, offering promising approach diabetes prevention treatment.

Language: Английский

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Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161732 - 161732

Published: March 1, 2025

Language: Английский

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Preparation and characterization of porous starch-based microcapsules loaded with insulin nanoparticles for controllable releasing properties

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106728 - 106728

Published: May 1, 2025

Language: Английский

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Layer‐by‐Layer Deposition of Antigen Peptides on Bifidobacterium for Subintestinal Lymphatic System‐Guided Personalized Tumor Immunotherapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Gut‐associated lymphoid tissue (GALT) possesses a highly specialized immune system and is rational as foothold for oral tumor vaccines. Here, noninvasive vaccine (Bif‐OVA‐Ocur) designed to engage GALT, inducing both intestinal mucosal systemic immunity therapeutics. The uses Bifidobacterium (Bif) delivery vehicle antigen peptides, which are coated with peptides (OVA) oxidized curdlan (Ocur) in layer‐by‐layer (LBL) manner. Upon administration, Bif‐OVA‐Ocur efficiently directed Peyer's patches (PPs) the intestines further presented antigen‐presenting cells (APCs), then migrate mesenteric lymph nodes (MLNs) evoke specific T cell responses. In mouse models, effectively boosts production of secretory immunoglobin A (SIgA) promotes strong response, leading significant suppression resistance challenges. Importantly, shows no toxicity. This approach harnessing offers valuable insights development other non‐invasive vaccines therapeutic agents.

Language: Английский

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Long-acting glucose-responsive insulin with swift onset-of-action

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113826 - 113826

Published: May 1, 2025

Language: Английский

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Glycan-Modified Cellular Nanosponges for Enhanced Treatment of Cholera Toxin-Induced Secretory Diarrhea

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Cholera is a severe infectious disease caused by the Gram-negative bacterium Vibrio cholerae after colonization in intestinal tract. toxin (CT), key exotoxin protein, primarily causes acute secretory diarrhea and life-threatening complications infected patients. Traditional approaches remain insufficient for effectively treating cholera, underscoring need innovative countermeasures to eliminate CT-caused symptoms. Here, we report glycan-modified cellular nanosponge enhanced treatment of CT-induced diarrhea. Specifically, epithelial cell membrane-camouflaged nanosponges are functionalized with glycan receptor promote their capability CT neutralization, thereby competitively inhibiting entry into host cells. Moreover, an inhibitor encapsulated synergistically improve therapeutic effect blocking excessive chloride ion efflux from cystic fibrosis transmembrane conductance regulator (a crucial anion channel) on membrane CT-intoxicated Upon oral administration, biomimetic nanomedicine eliminates injuries mice. Overall, this study highlights potential as promising broad-spectrum agents against bacterial exotoxins.

Language: Английский

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Emerging tumor hypoxia-relieving nanotherapeutics for boosting photodynamic therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 516, P. 163962 - 163962

Published: May 20, 2025

Language: Английский

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Polymeric Nanomedicines in Diabetic Wound Healing: Applications and Future Perspectives

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6423 - 6446

Published: May 1, 2025

The management of diabetic wound continues to pose significant clinical obstacles, primarily attributed bacterial infections, excessive inflammation, oxidative stress, and impaired angiogenesis. These pathological factors not only severely affect patient well-being but also create considerable burden on medical services. Current managements often show limited efficacy, necessitating the exploration alternative therapeutic strategies. Polymeric nanomedicines (PNs), owing their nanoscale properties, enhanced cellular uptake, stability, bioavailability, biocompatibility, have been broadly utilized for treatment. PNs demonstrate remarkable capabilities in microbial inhibition, inflammation regulation, stress mitigation, vascular network formation, particularly when combined with various agents, including organic substances (eg, exosomes), inorganic metals), biomaterials chitosan, hyaluronic acid, hydrogels). This article systematically examines recent progress PN-based interventions recovery, highlighting pivotal role mitigating infection, modulating inflammatory responses, promoting regeneration. Additionally, we provide a novel perspective multifunctionality potential overcoming limitations conventional therapies. Overall, represent an innovative promising approach management, outperforming therapies targeted delivery, multifunctionality. In future, investigations should concentrate refining formulations administration strategies so as enhance conducting well-designed trials validate efficacy.

Language: Английский

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