International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2798 - 2798
Published: Feb. 28, 2024
Oropharyngeal
squamous
cell
carcinoma
(OPSCC),
a
subset
of
head
and
neck
(HNSCC),
involves
the
palatine
tonsils,
soft
palate,
base
tongue,
uvula,
with
ability
to
spread
adjacent
subsites.
Personalized
treatment
strategies
for
Human
Papillomavirus-associated
oropharynx
(HPV+OPSCC)
are
yet
be
established.
In
this
article,
we
summarise
our
current
understanding
pathogenesis
HPV+OPSCC,
intrinsic
role
immune
system,
ICI
clinical
trials,
potential
small
molecule
immunotherapy
in
HPV+OPSCC.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(3)
Published: March 13, 2024
Altered
metabolism
represents
a
fundamental
difference
between
cancer
cells
and
normal
cells.
Cancer
have
unique
ability
to
reprogram
their
by
deviating
reliance
from
primarily
oxidative
phosphorylation
(OXPHOS)
glycolysis,
in
order
support
survival.
This
metabolic
phenotype
is
referred
as
the
“Warburg
effect”
associated
with
an
increase
glucose
uptake,
diversion
of
glycolytic
intermediates
alternative
pathways
that
anabolic
processes.
These
processes
include
synthesis
nucleic
acids,
lipids,
proteins,
necessary
for
rapidly
dividing
cells,
sustaining
growth,
proliferation,
capacity
successful
metastasis.
Triple-negative
breast
(TNBC)
one
most
aggressive
subtypes
cancer,
poorest
patient
outcome
due
its
high
rate
TNBC
characterized
elevated
glycolysis
certain
instances,
low
OXPHOS.
dysregulation
linked
chemotherapeutic
resistance
research
models
samples.
There
more
than
single
mechanism
which
this
switch
occurs
here,
we
review
current
knowledge
relevant
molecular
mechanisms
involved
advanced
metabolism,
focusing
on
TNBC.
Warburg
effect,
adaptations,
microRNA
regulation,
mitochondrial
involvement,
calcium
signaling,
recent
player
JAK/STAT
signaling.
In
addition,
explore
some
drugs
compounds
targeting
reprogramming.
Research
these
highly
promising
could
ultimately
offer
new
opportunities
development
innovative
therapies
treat
dysregulated
metabolism.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 8, 2024
Immune
checkpoint
blockade
(ICB)
improved
clinical
outcomes
in
renal
and
bladder
cancer
patients,
but
the
response
rates
remain
limited
especially
metastatic
disease.
While
STAT3
transcription
factor
is
well-known
master
regulator
of
tumor
immune
evasion,
little
known
about
role
resistance
or
cancers
to
immunotherapy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Exploration of Targeted Anti-tumor Therapy,
Journal Year:
2024,
Volume and Issue:
5(1), P. 20 - 33
Published: Jan. 17, 2024
Pancreatic
cancer
remains
a
serious
and
deadly
disease,
impacting
people
globally.
There
remain
prominent
gaps
in
the
current
understanding
of
specifically
regarding
role
signal
transducer
activator
transcription
(STAT)
family
proteins
pancreatic
tumors.
STAT
proteins,
particularly
STAT3,
play
important
roles
cancer,
especially
ductal
adenocarcinoma
(PDAC),
which
is
most
prevalent
histotype.
The
STAT3
across
continuum
molecular
processes,
such
as
PDAC
tumorigenesis
progression,
immune
escape,
drug
resistance
stemness,
modulation
tumor
microenvironment
(TME),
are
only
tip
iceberg.
In
some
ways,
may
hold
greater
importance
than
that
oncogenic
Kirsten
rat
sarcoma
virus
(KRAS).
This
makes
highly
attractive
target
for
developing
targeted
therapies
treatment
cancer.
this
review,
knowledge
has
been
summarized,
relating
to
activation
cells,
cells
TME,
state
targeting
pre-clinical
clinical
trials
PDAC.
Experimental and Therapeutic Medicine,
Journal Year:
2024,
Volume and Issue:
27(4)
Published: Feb. 5, 2024
Colorectal
cancer
(CRC)
is
one
of
the
most
prevailing
and
lethal
forms
globally.
α‑enolase
(ENO1)
has
been
well
documented
to
be
involved
in
progression
drug
resistance
CRC.
The
present
study
was
designed
specify
role
ENO1
major
events
during
process
CRC
introduce
its
latent
functional
mechanism.
expression
determined
by
western
blot
analysis.
Extracellular
acidification
rates
were
assessed
using
an
XF96
extracellular
flux
analyzer.
Glucose
uptake,
lactic
acid
production,
total
iron
levels
ferroptosis‑related
markers
examined
with
corresponding
kits.
A
dichlorodihydrofluorescein
diacetate
probe
measured
intracellular
reactive
oxygen
species
content.
Western
blotting
detected
glycolysis‑
proteins.
CCK‑8
EdU
staining
assays
cell
proliferation.
In
current
study,
highly
expressed
cells.
Knockdown
markedly
reduced
glycolysis
accelerated
ferroptosis
Moreover,
inhibitory
effects
WZB117,
a
specific
inhibitor
glycolysis‑related
glucose
transporter
type
1,
on
proliferation
further
enhanced
interference.
addition,
silencing
inactivated
AKT/STAT3
signaling.
AKT
activator
SC79
partially
reversed
deficiency
signaling,
glycolysis,
as
summary,
inactivation
signaling
mediated
inhibition
might
boost
suppress
