Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives DOI Open Access
Alan Soo Beng Khoo, Michael Boyer, Zuhayr Jafri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2798 - 2798

Published: Feb. 28, 2024

Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck (HNSCC), involves the palatine tonsils, soft palate, base tongue, uvula, with ability to spread adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated oropharynx (HPV+OPSCC) are yet be established. In this article, we summarise our current understanding pathogenesis HPV+OPSCC, intrinsic role immune system, ICI clinical trials, potential small molecule immunotherapy in HPV+OPSCC.

Language: Английский

Tumor-associated macrophages drive glycolysis through the IL-8/STAT3/GLUT3 signaling pathway in pancreatic cancer progression DOI
Ziyi Zhong, Kege Yang, Yunlong Li

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216784 - 216784

Published: March 6, 2024

Language: Английский

Citations

7
Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics DOI Creative Commons

Tian‐Hua Wei,

Meng‐Yi Lu,

Sihui Yao

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited benefits due to their lack of selectivity. This review focuses on structural analysis elucidate molecular determinants JAKs specificity and discovery design selective JAKi. It includes descriptions comparison different structures binding sites, comparative JAKi modes, detailed interaction fingerprints (IFPs), an extensive structure‐selectivity relationship (SSRs). Moreover, also explores challenges possibilities using computational structure‐based methods discovering designing Other approaches, such targeting pseudokinase domain, well covalent allosteric designs, are covered. Based this analysis, key corresponding rational medicinal chemistry strategies proposed facilitate development highly Overall, we aim enhance understanding explore that can lead effective in cancer therapy, thus improving prognosis patients.

Language: Английский

Citations

7
A Systematic Review of Proteomics in Obesity: Unpacking the Molecular Puzzle DOI Creative Commons
Alba Rodríguez-Muñoz, Hanieh Motahari-Rad,

Laura Martin-Chaves

et al.

Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 403 - 438

Published: May 4, 2024

The present study aims to review the existing literature identify pathophysiological proteins in obesity by conducting a systematic of proteomics studies. Proteomics may reveal mechanisms development and clarify links between related diseases, improving our comprehension its clinical implications.

Language: Английский

Citations

7
Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysis DOI Creative Commons
Wei Gao, Linlin Sun,

Jinwei Gai

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0297260 - e0297260

Published: Jan. 16, 2024

Background The triple negative breast cancer (TNBC) is the most malignant subtype of with high aggressiveness. Although paclitaxel-based chemotherapy scenario present mainstay in TNBC treatment, paclitaxel resistance still a striking obstacle for cure. So it imperative to probe new therapeutic targets through illustrating mechanisms underlying chemoresistance. Methods Single cell RNA sequencing (scRNA-seq) data cells treated at different points were downloaded from Gene Expression Omnibus (GEO) database. Seurat R package was used filter and integrate scRNA-seq expression matrix. Cells further clustered by FindClusters function, gene marker each subset defined FindAllMarkers function. Then, hallmark score calculated AUCell package, biological function highly expressed interest genes analyzed DAVID Subsequently, we performed pseudotime analysis explore change patterns drug SCENIC identify key transcription factors (TFs). Finally, inhibitors which also CTD Results We finally obtained 6 subsets 2798 cells, marked as AKR1C3+, WNT7A+, FAM72B+, RERG+, IDO1+ HEY1+HCC1143 subsets, among HEY1+ proportions increased increasing treatment time, then regarded subsets. Hallmark showed that these associated inflammatory response, virus interferon response activation. In addition, regulatory networks (GRNs) indicated 3 TFs (STAT1, CEBPB IRF7) played vital role promoting development, five common targeted potential combination therapies identified. Conclusion this study, identified relevant IFs their inhibitors, offers essential molecular basis beneficial guidance clinical therapy.

Language: Английский

Citations

6
Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives DOI Open Access
Alan Soo Beng Khoo, Michael Boyer, Zuhayr Jafri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2798 - 2798

Published: Feb. 28, 2024

Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck (HNSCC), involves the palatine tonsils, soft palate, base tongue, uvula, with ability to spread adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated oropharynx (HPV+OPSCC) are yet be established. In this article, we summarise our current understanding pathogenesis HPV+OPSCC, intrinsic role immune system, ICI clinical trials, potential small molecule immunotherapy in HPV+OPSCC.

Language: Английский

Citations

6