Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

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Lymphangiogenesis orchestrating tumor microenvironment: Face changing in immunotherapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189278 - 189278

Published: Feb. 1, 2025

Language: Английский

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The immunological pathogenesis of IgG4-related disease categorized by clinical characteristics

Immunological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Sept. 22, 2024

IgG4-related disease (IgG4-RD) is an immune disorder characterized by organ enlargement and fibrosis leading to functional impairment. Key cell subsets contributing the pathogenesis of IgG4-RD include T follicular helper 2 cells (Tfh2), Tfh1, CX3CR1 + cytotoxic (CX3CR1 CTLs), Tregs IgG4 B cells. Tfh2 are commonly involved in inducing class-switching this disease. Importantly, can be classified into four clinical phenotypes based on distribution affected organs, with each phenotype showing different dominant its pathogenesis. Specifically, retroperitoneal fibrosis/aortitis CTLs as key subset, while Mikulicz systemic involvement dominated Tfh2. In addition classification distribution, also categorized associated malignancy or allergy. The increase CXCR5 CD2-double negative compared allergy phenotype, along a decrease naive CD8 Moreover, several autoantigens have been identified, presence autoimmune has revealed. Due pathogenicity IgG1-type autoantibodies, Tfh1 may important IgG1 IFNγ phenotype. hypocomplementemia, activation complement pathway thought induced IgG2 antibodies, suggesting Therefore, elucidating immunological features specific characteristic believed lead deeper understanding discovery novel therapeutic targets. This review provides overview mechanisms common well those characteristic.

Language: Английский

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Lymphatic collection and cell isolation from mouse models for multiomic profiling

Nature Protocols, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Biflex Self Adjust: a compression wrap system for lymphoedema and venous leg ulcers

British Journal of Community Nursing, Journal Year: 2025, Volume and Issue: 30(2), P. 60 - 66

Published: Feb. 2, 2025

Compression is the foundation of treatment for chronic oedema, including lymphoedema and venous insufficiency (CVI). However, adherence with conventional compression wraps often poor. This article introduces Biflex Self Adjust, a new wrap system leg ulcers, common consequence CVI. A Velcro an integrated loop ensures patients can easily quickly take Adjust on off. uses patented device that allows healthcare professionals to adjust pressure. In addition, completely covers limb using optimised number overlapping bandages, which helps prevent oedema migration. The open-cell foam used in moisture transfer, enhances comfort. Case studies illustrate effectiveness clinical practice.

Language: Английский

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Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Enhanced transport of immunomodulators via the lymphatics may increase drug exposure to therapeutic targets in immune system. Our laboratory has demonstrated a triglyceride (TG) mimetic prodrug approach enhance lymphatic delivery model immunomodulator, mycophenolic acid (MPA), conjugation carboxylic MPA TG backbone, where so formed is able incorporate into intestinal deacylation–reacylation and lymph lipoprotein pathways (up 37% administered dose being absorbed lymphatics). In current study, another site molecule MPA, i.e., phenolic group, was explored for its potential optimize profiles prodrugs MPA. This offers an unusual opportunity directly compare utility versus phenol same core molecule, which not been examined previously other parent drugs. A series linkers were connect moiety with backbone. Lymphatic assessed mesenteric duct cannulated rats, nodes following oral administration mice. Compared data observed conjugated acid, new phenol-conjugated showed clearly different terms linker chemistry. Prodrugs shorter chain alkyl spacers (e.g., C4 C6) supported minimal (<3% recovered lymph). When lengths longer (≥C10), much higher approximately 55% dose). Although effectively promoting transport, did necessarily result marked increases Subsequently number self-immolative promote liberation from prodrugs, these constructs enhanced node exposure. study provides further insight structure–lymphatic relationships lymph-directing lipid prodrugs.

Language: Английский

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Positive sentinel lymph node biopsy on promotion of metastasis: An unexpected effect?

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111624 - 111624

Published: April 1, 2025

Language: Английский

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Pan-cancer human brain metastases atlas at single-cell resolution

Cancer Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Lymphatic system regulation of anti-cancer immunity and metastasis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Cancer dissemination to lymph nodes (LN) is associated with a worse prognosis, increased incidence of distant metastases and reduced response therapy. The LN microenvironment puts selective pressure on cancer cells, creating cells that can survive in as well providing survival advantages for metastatic spread. Additionally, the presence leads an immunosuppressive microenvironment, favoring evasion anti-cancer immune surveillance. However, recent studies have also characterized previously unrecognized roles tumor-draining (TDLNs) immunotherapy response, including acting reservoir pre-exhausted CD8+ T stem-like cells. In this review, we will discuss spread through lymphatic system, TDLNs metastasis responses, therapeutic opportunities challenges targeting metastasis.

Language: Английский

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Breast cancer-related lymphoedema: advances and outstanding issues

British Journal of Community Nursing, Journal Year: 2024, Volume and Issue: 29(Sup10), P. S26 - S28

Published: Oct. 1, 2024

Optimal management of breast cancer-related lymphoedema (BCRL), a common and debilitating complication surgery radiotherapy, depends on early detection, personalised risk assessment proactive intervention. For instance, recent review advises healthcare professionals to reframe the narrative about daily-living skin trauma risks away from ‘what avoid’ do’. Another recommends daily, or nearly exercise at home reduce severity. However, several questions await full answers. There is, for no consensus regarding most appropriate surgical technique preventing BCRL. This feature summarises some papers updating

Language: Английский

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