Immuno-oncological Challenges and Chemoresistance in Veterinary Medicine: Probiotics as a New Strategic Tool

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

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A Multifunctional Nanoplatform Based on Carbon Nanotubes Loaded with Persistent Luminescent Nanoparticles for Photocatalysis, Photothermal Therapy, and Drug Delivery Applications

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13592 - 13604

Published: Feb. 18, 2025

Persistent luminescent nanoparticles (PLNPs) exhibit ultralong afterglow properties due to their excellent light storage mechanism and great potential for biomedical, energy, environmental applications. However, PLNPs have certain limitations regarding photogenerated carrier separation efficiency, absorption range, specific surface area, which limit efficiency performance in practical Herein, we reported a multifunctional nanoplatform based on carbon nanotubes (CNTs) loaded with (ZnGa1.97O4:Cr0.01, Bi0.02, ZGO). Experimental characterizations density functional theory calculations showed that the combination of CNTs significantly reduced recombination carriers PLNPs, increased enhanced intensity near-infrared (NIR) region. By optimizing ratio, ZGO-10CNTs not only exhibited greatest photocatalytic activity pollutant degradation but also generating reactive oxygen species, demonstrating therapy In addition, demonstrated NIR photothermal conversion pH-responsive drug release. The integration led development capabilities degradation, therapy, delivery, thus expanding design nanoplatforms PLNPs. construction this provides new strategies cancer opens up perspectives applications energy fields.

Language: Английский

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Construction and application of a large capacity VNAR library from the whitespotted bamboo shark (Chiloscyllium playgiosum)

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Exploring imaged capillary isoelectric focusing parameters for enhanced charge variants quality control

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 20, 2025

Biopharmaceuticals are increasingly utilised in the treatment of oncological, inflammatory, and autoimmune diseases, largely due to their exceptional specificity targeting antigens. However, structural complexity, heterogeneity, sensitivity pose crucial challenges production, purification, delivery. Charge heterogeneity analysis, a Critical Quality Attribute these biomolecules used Control, is often performed using separative analytical techniques such as imaged capillary Isoelectric Focusing (icIEF). Recognized gold standard by industry, icIEF leverages pH gradient provide high-resolution profiling charge variants biotherapeutics. In this review, critical experimental parameters for method development context biotherapeutic drug QC will be discussed. Key aspects, including sample preparation, properties, carrier ampholytes, stabilizers, detection examined, supported recent literature. Advances technology its expanding applications underline robustness, reproducibility, compliance with regulatory standards, affirming pivotal role ensuring identity consistency biological products.

Language: Английский

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Integration of QSAR Models with High Throughput Screening to Accelerate the Development of Polishing Chromatography Unit Operations

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1747, P. 465818 - 465818

Published: Feb. 25, 2025

Language: Английский

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