Targeting senescent cells to attenuate cardiovascular disease progression DOI Creative Commons

Ping Song,

Qiang Zhao,

Ming-Hui Zou

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101072 - 101072

Published: April 14, 2020

Cardiovascular disease (CVD) is the most common to increase as life expectancy increases. Most high-profile pharmacological treatments for age-related CVD have led inefficacious results, implying that novel approaches treating these pathologies are needed. Emerging data demonstrated senescent cardiovascular cells, which characterized by irreversible cell cycle arrest and a distinct senescence-associated secretory phenotype, accumulate in aged or diseased systems, suggesting they may impair function. This review discusses evidence implicating cells ageing, onset progression of CVD, molecular mechanisms underlying senescence. We also eradication small-molecule-drug-mediated apoptosis immune cell-mediated efferocytosis toxicity promising precisely targeted therapeutics prevention treatment.

Language: Английский

Mitochondrial quality control: Biochemical mechanism of cardiovascular disease DOI Creative Commons

Francesca Inferrera,

Ylenia Marino,

Tiziana Genovese

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119906 - 119906

Published: Jan. 19, 2025

Language: Английский

Citations

1
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity DOI Creative Commons
Partha Mukhopadhyay,

Burhan Yokus,

Bruno Paes‐Leme

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, DNA injury, impaired lipid metabolism, cell death, senescence, chronic inflammation. These processes lead to remodeling structural changes in the system, resulting a progressive decline reserve capacity health, an increased risk diseases mortality. Excessive alcohol consumption exacerbates these risks by promoting hypertension, stroke, arrhythmias, coronary artery disease, cardiomyopathy, sudden cardiac yet effects on remain unclear. Herein, we explored impact 6-month 5% Lieber-DeCarli diet young (3 months old) (24–26 Fisher F344BNF1 rats. We assessed detailed hemodynamics, function, oxidative/nitrative inflammation, myocardial fibrosis using pressure–volume isolated vascular rings, various histological, biochemical, molecular biology methods. Alcohol both rats disrupted cholesterol triglyceride leading systolic contractile function. In rats, further exacerbated diastolic dysfunction fibrosis. also apoptosis, senescence vasculature, contributing endothelial total peripheral resistance. Additionally, aging-related ventriculo-arterial uncoupling diminished efficiency, reducing capacity. conclusion, promotes diminishes already associated with aging.

Language: Английский

Citations

1
Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives DOI Open Access
Rita Del Pinto, Claudio Ferri

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(12), P. 3701 - 3701

Published: Nov. 22, 2018

Low-grade chronic inflammation is a common denominator in atherogenesis and related diseases. Solid evidence supports the occurrence of an impairment innate adaptive immune system with senescence, favoring development acute age-related Cardiovascular (CV) diseases (CVD), particular, are leading cause death even at older ages. Inflammation-associated mechanisms that contribute to CVD include dysregulated redox metabolic pathways, genetic modifications, infections/dysbiosis. In this review, we will recapitulate determinants consequences dysfunction age, particular focus on CV system. We examine currently available potential future strategies counteract accelerated aging, i.e., nutraceuticals, probiotics, caloric restriction, physical activity, smoking alcohol cessation, control low-grade sources, senolytic senescence-modulating drugs, DNA-targeting drugs.

Language: Английский

Citations

68
Telomere transcription in ageing DOI
Julio Aguado, Fabrizio d’Adda di Fagagna, Ernst J. Wolvetang

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 62, P. 101115 - 101115

Published: June 18, 2020

Language: Английский

Citations

61
Targeting senescent cells to attenuate cardiovascular disease progression DOI Creative Commons

Ping Song,

Qiang Zhao,

Ming-Hui Zou

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101072 - 101072

Published: April 14, 2020

Cardiovascular disease (CVD) is the most common to increase as life expectancy increases. Most high-profile pharmacological treatments for age-related CVD have led inefficacious results, implying that novel approaches treating these pathologies are needed. Emerging data demonstrated senescent cardiovascular cells, which characterized by irreversible cell cycle arrest and a distinct senescence-associated secretory phenotype, accumulate in aged or diseased systems, suggesting they may impair function. This review discusses evidence implicating cells ageing, onset progression of CVD, molecular mechanisms underlying senescence. We also eradication small-molecule-drug-mediated apoptosis immune cell-mediated efferocytosis toxicity promising precisely targeted therapeutics prevention treatment.

Language: Английский

Citations

59