Neurocardiology: translational advancements and potential DOI Creative Commons
Neil Herring, Olujimi A. Ajijola,

Robert D. Foreman

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract In our original white paper published in the The Journal of Physiology 2016, we set out knowledge structural and functional organization cardiac autonomic control, how it remodels during disease, approaches to exploit such for regulation therapy. aim this update is build on blueprint, highlighting significant progress which has been made field since major challenges opportunities that exist with regard translation. Imbalances responses, while beneficial short term, ultimately contribute evolution pathology. As understanding emerges where target terms actuators (including heart intracardiac nervous system (ICNS), stellate ganglia, dorsal root ganglia (DRG), vagus nerve, brainstem, even higher centres), there also a need develop sensor technology respond appropriate biomarkers (electrophysiological, mechanical, molecular) closed‐loop therapies can evolve. goal work endogenous control systems, rather than opposition them, improve outcomes. image

Language: Английский

Spatially resolved multiomics of human cardiac niches DOI Creative Commons
Kazumasa Kanemaru, James Cranley, Daniele Muraro

et al.

Nature, Journal Year: 2023, Volume and Issue: 619(7971), P. 801 - 810

Published: July 12, 2023

The function of a cell is defined by its intrinsic characteristics and niche: the tissue microenvironment in which it dwells. Here we combine single-cell spatial transcriptomics data to discover cellular niches within eight regions human heart. We map cells microanatomical locations integrate knowledge-based unsupervised structural annotations. also profile cardiac conduction system

Language: Английский

Citations

154
Monolithic silicon for high spatiotemporal translational photostimulation DOI
Pengju Li, Jing Zhang, Hidenori Hayashi

et al.

Nature, Journal Year: 2024, Volume and Issue: 626(8001), P. 990 - 998

Published: Feb. 21, 2024

Language: Английский

Citations

41
Publication guidelines for human heart rate and heart rate variability studies in psychophysiology—Part 1: Physiological underpinnings and foundations of measurement DOI Creative Commons
Karen S. Quigley, Peter J. Gianaros, Greg J. Norman

et al.

Psychophysiology, Journal Year: 2024, Volume and Issue: 61(9)

Published: June 14, 2024

This Committee Report provides methodological, interpretive, and reporting guidance for researchers who use measures of heart rate (HR) variability (HRV) in psychophysiological research. We provide brief summaries best practices measuring HR HRV via electrocardiographic photoplethysmographic signals laboratory, field (ambulatory), brain-imaging contexts to address research questions incorporating HRV. The emphasizes evidence the strengths weaknesses different recording derivation methods Along with this guidance, reviews what is known about origin heartbeat its neural control, including factors that produce influence metrics. concludes checklists guide authors study design analysis considerations, as well on key methodological details characteristics samples under study. It expected rigorous transparent will strengthen inferences across many applications these metrics psychophysiology. prior Reports are several decades old. Since their appearance, technologies human cardiac vascular monitoring laboratory daily life (i.e., ambulatory) have greatly expanded. was prepared Society Psychophysiological Research updated interpretive summarize studies humans.

Language: Английский

Citations

24
Severe mental illness: cardiovascular risk assessment and management DOI Creative Commons
Christoffer Polcwiartek, Kevin O’Gallagher, Daniel J. Friedman

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(12), P. 987 - 997

Published: Feb. 21, 2024

Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die on average 15-20 years earlier than the general population often due to sudden death that, in most cases, is caused by cardiovascular disease. This state-of-the-art review aims address complex association between SMI risk, explore disparities care pathways, describe how adequately predict outcomes, propose targeted interventions improve health patients SMI. These have an adverse risk factor profile interplay biological factors such as chronic inflammation, patient excessive smoking, healthcare system stigma discrimination. Several pathways been demonstrated SMI, resulting a 47% lower likelihood of undergoing invasive coronary procedures substantially rates prescribed standard secondary prevention medications compared population. Although early prediction important, conventional models do not accurately long-term outcomes disease mortality are only partly driven traditional this group. As such, SMI-specific clinical tools electrocardiogram echocardiogram necessary when assessing managing associated In conclusion, there necessity for differentiated By addressing involved excess reconsidering stratification approaches, implementing multidisciplinary models, clinicians can take steps towards improving

Language: Английский

Citations

23
Advances in bio-integrated wearable and implantable optoelectronic devices for cardiac healthcare DOI Creative Commons
Cheng Li,

Yangshuang Bian,

Zhiyuan Zhao

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous comfortable for patients. Recently, wearable implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological in an imperceptible spatiotemporally unconstrained manner, opening countless possibilities intelligent healthcare paradigm. To achieve biointegrated cardiac healthcare, researchers have focused on novel strategies construction flexible/stretchable systems. Here, we overview progress flexible stretchable optoelectronics devices. Firstly, device design addressed, including mechanical design, interface adhesion, encapsulation strategies. Next, practical applications monitoring, optogenetics, nongenetic stimulation are presented. Finally, outlook systems discussed.

Language: Английский

Citations

17
Emerging Materials and Technologies with Applications in Flexible Neural Implants: A Comprehensive Review of Current Issues with Neural Devices DOI Creative Commons

Younguk Cho,

Sanghoon Park, Juyoung Lee

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(47)

Published: May 29, 2021

Abstract Neuroscience is an essential field of investigation that reveals the identity human beings, with a comprehensive understanding advanced mental activities, through study neurobiological structures and functions. Fully neurotransmission system allows for connectivity among neuronal circuits has paved way development treatments neurodegenerative diseases such as Parkinson's disease, Alzheimer's depression. The flexible implants attracted increasing interest mainly to overcome mechanical mismatch between rigid electrode materials soft neural tissues, enabling precise measurements signals from conformal contact. Here, current issues (chronic device failure, non‐bioresorbable electronics, low‐density arrays, others are summarized) by presenting material candidates designs address each challenge. Furthermore, latest investigations associated aforementioned also introduced, including suggestions ideal implants. In terms future direction these advances, designing devices would provide new opportunities brain–machine interfaces or brain–computer part locomotion brain signals, treatment diseases.

Language: Английский

Citations

89
The role of the autonomic nervous system in cardiac arrhythmias: The neuro-cardiac axis, more foe than friend? DOI

Antonis A. Manolis,

Theodora A. Manolis,

Evdoxia J. Apostolopoulos

et al.

Trends in Cardiovascular Medicine, Journal Year: 2020, Volume and Issue: 31(5), P. 290 - 302

Published: May 17, 2020

Language: Английский

Citations

84
The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade DOI Creative Commons
Manish Kalla, Guoliang Hao, Nidi Tapoulal

et al.

European Heart Journal, Journal Year: 2019, Volume and Issue: 41(23), P. 2168 - 2179

Published: Nov. 12, 2019

ST-elevation myocardial infarction is associated with high levels of cardiac sympathetic drive and release the co-transmitter neuropeptide Y (NPY). We hypothesized that despite beta-blockade, NPY promotes arrhythmogenesis via ventricular myocyte receptors.

Language: Английский

Citations

82
The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction DOI Creative Commons
Laura Fedele, Thomas Brand

Journal of Cardiovascular Development and Disease, Journal Year: 2020, Volume and Issue: 7(4), P. 54 - 54

Published: Nov. 24, 2020

The cardiac autonomic nervous system (CANS) plays a key role for the regulation of activity with its dysregulation being involved in various heart diseases, such as arrhythmias. CANS comprises extrinsic and intrinsic innervation heart. (ICNS) includes network intracardiac ganglia interconnecting neurons. contribute to tight modulation electrophysiology, working local hub integrating inputs ICNS. A better understanding ICNS conduction will be crucial targeted therapies We describe embryonic development, anatomy, physiology By correlating topography neurons what is known regarding their biophysical neurochemical properties, we outline physiological control pacemaker sinoatrial atrioventricular nodes. conclude by highlighting disorders putative involvement open questions that need addressed order understand pathophysiology

Language: Английский

Citations

78
Neutrophils incite and macrophages avert electrical storm after myocardial infarction DOI Creative Commons
Jana Grune, Andrew Lewis,

Masahiro Yamazoe

et al.

Nature Cardiovascular Research, Journal Year: 2022, Volume and Issue: 1(7), P. 649 - 664

Published: July 11, 2022

Abstract Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukocyte changes. In this study, we optimized a mouse model which hypokalemia combined infarction triggered spontaneous ventricular tachycardia ambulatory mice, showed that major subsets have opposing effects on conduction. Neutrophils increased via lipocalin-2 whereas neutrophilia associated patients. contrast, macrophages protected against arrhythmia. Depleting recruited Ccr2 −/− mice or all macrophage Csf1 receptor inhibition both fibrillation. Higher burden mortality Cd36 Mertk viewed together reduced mitochondrial integrity accelerated cardiomyocyte death the absence of macrophages, indicated receptor-mediated phagocytosis protects lethal storm. Thus, modulation function provides potential therapeutic pathway for reducing risk sudden death.

Language: Английский

Citations

64