Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 24, 2021
Abstract
As
a
classically
known
mitogen,
fibroblast
growth
factor
1
(FGF1)
has
been
found
to
exert
other
pleiotropic
functions
such
as
metabolic
regulation
and
myocardial
protection.
Here,
we
show
that
serum
levels
of
FGF1
were
decreased
positively
correlated
with
fraction
shortening
in
diabetic
cardiomyopathy
(DCM)
patients,
indicating
is
potential
therapeutic
target
for
DCM.
We
treatment
variant
(FGF1
∆HBS
)
reduced
proliferative
potency
prevented
diabetes-induced
cardiac
injury
remodeling
restored
function.
RNA-Seq
results
obtained
from
the
tissues
db/db
mice
showed
significant
increase
expression
anti-oxidative
genes
decrease
Nur77
by
treatment.
Both
vivo
vitro
studies
indicate
exerted
these
beneficial
effects
markedly
reducing
mitochondrial
fragmentation,
reactive
oxygen
species
(ROS)
generation
cytochrome
c
leakage
enhancing
respiration
rate
β-oxidation
5’
AMP-activated
protein
kinase
(AMPK)/Nur77-dependent
manner,
all
which
not
observed
AMPK
null
mice.
The
favorable
activity
properties
testify
its
promising
use
DCM
disorders.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
8
Published: Jan. 12, 2021
Cardiac
tissue
requires
a
persistent
production
of
energy
in
order
to
exert
its
pumping
function.
Therefore,
the
maintenance
this
function
relies
on
mitochondria
that
represent
“powerhouse”
all
cardiac
activities.
Mitochondria
being
one
key
players
for
proper
functioning
mammalian
heart
suggests
continual
regulation
and
organization.
adapt
cellular
demands
via
fusion-fission
events
and,
as
proof-reading
ability,
undergo
mitophagy
cases
abnormalities.
Ca
2+
fluxes
play
pivotal
role
regulating
mitochondrial
functions,
including
ATP
production,
metabolism,
oxidative
stress
balance
apoptosis.
Communication
between
others
organelles,
especially
sarcoplasmic
reticulum
is
required
optimal
Consequently,
abnormal
activity
results
decreased
leading
pathological
conditions.
In
review,
we
will
describe
how
or
dysfunction
impacts
activities
development
dilated
cardiomyopathy.
Frontiers in Cell and Developmental Biology,
Journal Year:
2020,
Volume and Issue:
8
Published: Nov. 9, 2020
The
endoplasmic
reticulum
(ER)
and
mitochondria
are
physically
connected
to
form
dedicated
structural
domains
known
as
mitochondria-associated
ER
membranes
(MAMs),
which
participate
in
fundamental
biological
processes,
including
lipid
calcium
(Ca2+)
homeostasis,
mitochondrial
dynamics
other
related
cellular
behaviors
such
autophagy,
stress,
inflammation
apoptosis.
Many
studies
have
proved
the
importance
of
MAMs
maintaining
normal
function
both
organelles,
abnormal
amount,
structure
or
is
occurrence
cardiovascular
diseases.
Here,
we
review
knowledge
regarding
components
according
their
different
functions
specific
roles
physiology
pathophysiology,
focusing
on
some
highly
prevalent
diseases,
ischemia-reperfusion,
diabetic
cardiomyopathy,
heart
failure,
pulmonary
arterial
hypertension
systemic
vascular
Finally,
summarize
possible
mechanisms
MAM
diseases
put
forward
obstacles
understanding
may
encounter.
Frontiers in Physiology,
Journal Year:
2021,
Volume and Issue:
12
Published: April 27, 2021
Mitochondrial
dysfunction
is
a
crucial
contributor
to
heart
diseases.
Alterations
in
energetic
metabolism
affect
homeostatic
processes,
such
asATP
production,
the
generation
of
reactive
oxygen
species,
and
release
pro-apoptotic
factors,
associated
with
metabolic
abnormalities.
In
response
deficiency,
cardiomyocytes
activate
Quality
Control
(MQC),
critical
process
maintaining
mitochondrial
health.
This
compromised
cardiovascular
diseases
depending
on
pathology's
severity
represents,
therefore,
potential
therapeutic
target.
Several
targeting
molecules
within
this
have
been
identified
last
years,
strategies
proposed
ameliorate
mitochondria
monitoring
function.
context,
physical
exercise
considered
non-pharmacological
strategy
protect
Physical
regulates
MQC
allowing
repair/elimination
damaged
synthesizing
new
ones,
thus
recovering
state.
review,
we
will
deal
effect
cardiac
function
tracing
its
ability
modulate
specific
steps
both
physiologic
pathologic
conditions.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 24, 2021
Abstract
As
a
classically
known
mitogen,
fibroblast
growth
factor
1
(FGF1)
has
been
found
to
exert
other
pleiotropic
functions
such
as
metabolic
regulation
and
myocardial
protection.
Here,
we
show
that
serum
levels
of
FGF1
were
decreased
positively
correlated
with
fraction
shortening
in
diabetic
cardiomyopathy
(DCM)
patients,
indicating
is
potential
therapeutic
target
for
DCM.
We
treatment
variant
(FGF1
∆HBS
)
reduced
proliferative
potency
prevented
diabetes-induced
cardiac
injury
remodeling
restored
function.
RNA-Seq
results
obtained
from
the
tissues
db/db
mice
showed
significant
increase
expression
anti-oxidative
genes
decrease
Nur77
by
treatment.
Both
vivo
vitro
studies
indicate
exerted
these
beneficial
effects
markedly
reducing
mitochondrial
fragmentation,
reactive
oxygen
species
(ROS)
generation
cytochrome
c
leakage
enhancing
respiration
rate
β-oxidation
5’
AMP-activated
protein
kinase
(AMPK)/Nur77-dependent
manner,
all
which
not
observed
AMPK
null
mice.
The
favorable
activity
properties
testify
its
promising
use
DCM
disorders.
