Long-term cardiovascular outcomes of COVID-19

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(3), P. 583 - 590

Published: Feb. 7, 2022

Abstract The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute manifestations COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from US Department Veterans Affairs to build a cohort 153,760 individuals with COVID-19, as two sets control cohorts 5,637,647 (contemporary controls) and 5,859,411 (historical individuals, estimate risks 1-year burdens set pre-specified incident outcomes. We show that, beyond first 30 d after infection, at increased risk spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic non-ischemic heart disease, pericarditis, myocarditis, failure thromboembolic disease. These were evident even among who hospitalized during phase infection in graded fashion according care setting (non-hospitalized, admitted intensive care). Our results provide evidence that burden survivors substantial. Care pathways those surviving episode should include attention health

Language: Английский

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The Global Burden of Cardiovascular Diseases and Risk

Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 80(25), P. 2361 - 2371

Published: Nov. 9, 2022

Language: Английский

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European Society of Cardiology: cardiovascular disease statistics 2021

European Heart Journal, Journal Year: 2021, Volume and Issue: 43(8), P. 716 - 799

Published: Dec. 20, 2021

Abstract Aims This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon widely cited 2019 in presenting cardiovascular disease (CVD) statistics for 57 ESC member countries. Methods results Statistics pertaining to 2019, or latest available year, are presented. Data sources include World Health Organization, Institute Metrics Evaluation, Bank, novel sponsored data on human capital infrastructure healthcare delivery. New material this includes sociodemographic environmental determinants CVD, rheumatic heart disease, out-of-hospital cardiac arrest, left-sided valvular advocacy potential these CVD statistics, progress towards Organization (WHO) 2025 targets non-communicable diseases. Salient observations report: (i) Females born countries 2018 expected live 80.8 years males 74.8 years. Life expectancy is longer high income (81.6 years) compared with middle-income (74.2 (ii) In 2018, high-income spent, average, four times more than (iii) The median PM2.5 concentrations were over twice as exceeded EU air quality standard 14 countries, all middle-income. (iv) 2016, one five adults across obese similar prevalence low-income obesity has doubled past 35 (v) burden falls hardest where estimated incidence rates ∼30% higher reflected disability-adjusted life due which nearly (vi) calcific aortic valve increased seven-fold during last 30 years, age-standardized (vii) Although total number deaths far exceeds cancer both sexes, there 15 accounts five-member females. (viii) under-resourced status associated a severe procedural deficit terms coronary intervention, ablation procedures, device implantation, surgical procedures. Conclusion Risk factors unhealthy behaviours potentially reversible, provides huge opportunity address health inequalities that highlighted report. It seems clear, however, efforts seize falling short present evidence suggests most WHO NCD unlikely be met

Language: Английский

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Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

Nature Reviews Endocrinology, Journal Year: 2021, Volume and Issue: 17(3), P. 135 - 149

Published: Jan. 21, 2021

Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer nonalcoholic fatty liver otherwise known as associated disease (MAFLD). With worldwide spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2), obesity also emerged important determinants 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral characteristics such hyperglycaemia, hypertension subclinical inflammation with a high COVID-19. In this Review, we highlight how increase complications mortality in We summarize consequences SARS-CoV-2 infection organ function NCDs. addition, discuss data indicating COVID-19 pandemic could have serious epidemic. As both accelerators COVID-19, might adversely influence efficacy vaccines, propose strategies prevention treatment on clinical population level, particularly while is present. This Review highlights (COVID-19) summarizes function. there discussion implications pandemic.

Language: Английский

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Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Dec. 24, 2020

Abstract On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by World Health Organization. As 4 August more than 18 million confirmed infections had been reported globally. Most patients have mild symptoms, but some develop respiratory failure which is leading cause death among COVID-19 patients. Endothelial cells with high levels angiotensin-converting enzyme 2 expression are major participants and regulators inflammatory reactions coagulation. Accumulating evidence suggests that endothelial activation dysfunction participate in pathogenesis altering integrity vessel barrier, promoting pro-coagulative state, inducing inflammation, even mediating leukocyte infiltration. This review describes proposed cellular molecular mechanisms during emphasizing principal mediators therapeutic implications.

Language: Английский

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The role of cardiac rehabilitation in improving cardiovascular outcomes

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 19(3), P. 180 - 194

Published: Sept. 16, 2021

Language: Английский

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Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study

The Lancet Digital Health, Journal Year: 2021, Volume and Issue: 3(4), P. e217 - e230

Published: Feb. 21, 2021

BackgroundThere are concerns that the response to COVID-19 pandemic in UK might have worsened physical and mental health, reduced use of health services. However, scale problem is unquantified, impeding development effective mitigations. We aimed ascertain what has happened general practice contacts for acute outcomes during pandemic.MethodsUsing de-identified electronic records from Clinical Research Practice Datalink (CPRD) Aurum (covering 13% population), between 2017 2020, we calculated weekly primary care selected conditions: anxiety, depression, self-harm (fatal non-fatal), severe illness, eating disorder, obsessive-compulsive alcohol-related events, asthma exacerbation, chronic obstructive pulmonary disease cardiovascular events (cerebrovascular accident, heart failure, myocardial infarction, transient ischaemic attacks, unstable angina, venous thromboembolism), diabetic emergency. Primary included remote face-to-face consultations, diagnoses hospital discharge letters, secondary referrals, conditions were identified through diagnoses, symptoms, prescribing. Our overall study population individuals aged 11 years or older who had at least 1 year registration with practices contributing CPRD specified period, but denominator populations varied depending on condition being analysed. used an interrupted time-series analysis formally quantify changes after introduction population-wide restrictions (defined as March 29, 2020) compared period before their Jan 1, 7, 2020), data excluded adjustment-to-restrictions (March 8–28).FindingsThe 9 863 903 2017, increased 10 226 939 by 2020. almost all dropped considerably restrictions. The largest reductions observed emergencies (odds ratio 0·35 [95% CI 0·25–0·50]), depression (0·53 [0·52–0·53]), (0·56 [0·54–0·58]). In analysis, exception (0·98 [0·89–1·10]), there was evidence a reduction (anxiety 0·67 [0·66–0·67], disorders 0·62 [0·59–0·66], disorder [0·69 [0·64–0·74]], 0·56 [0·54–0·58], illness 0·80 [0·78–0·83], stroke 0·59 [0·56–0·62], attack 0·63 [0·58–0·67], failure [0·60–0·64], infarction 0·72 [0·68–0·77], angina [0·60–0·87], thromboembolism 0·94 [0·90–0·99], exacerbation 0·88 [0·86–0·90]). By July, except not recovered pre-lockdown levels.InterpretationThere substantial following restrictions, limited recovery Further research needed whether these reflect frequency missed opportunities care. Maintaining health-care access should be key priority future public planning, including further studied sufficiently any unmet need will ramifications people well provision.FundingWellcome Trust Senior Fellowship, Health Data UK.

Language: Английский

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COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies

Molecular Pharmaceutics, Journal Year: 2021, Volume and Issue: 18(3), P. 754 - 771

Published: Jan. 19, 2021

At the stroke of New Year 2020, COVID-19, a zoonotic disease that would turn into global pandemic, was identified in Chinese city Wuhan. Although unique its transmission and virulence, COVID-19 is similar to diseases, including other SARS variants (e.g., SARS-CoV) MERS, exhibiting severe flu-like symptoms acute respiratory distress. Even at molecular level, many parallels have been between so much virus has named SARS-CoV-2. These similarities provided several opportunities treat patients using clinical approaches were proven be effective against SARS. Importantly, identification how SARS-CoV SARS-CoV-2 access host, replicate, trigger life-threatening pathological conditions revealed repurpose drugs In this article, we first an overview etiology vis-à-vis particularly MERS. Then, summarized characteristics droplets/aerosols emitted by they aid among people. Moreover, discussed mechanisms enable host become more contagious than betacoronaviruses such as SARS-CoV. Further, outlined various are currently being employed diagnose symptomatically clinic. Finally, reviewed technologies develop vaccines attempts classes novel therapeutic approaches.

Language: Английский

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Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms

Journal of Translational Autoimmunity, Journal Year: 2021, Volume and Issue: 4, P. 100100 - 100100

Published: Jan. 1, 2021

Impairment of health after overcoming the acute phase COVID-19 is being observed more and frequently. Here different symptoms neurological and/or cardiological origin have been reported. With symptoms, which are very similar to ones reported but not caused by SARS-CoV-2, occurrence functionally active autoantibodies (fAABs) targeting G-protein coupled receptors (GPCR-fAABs) has discussed be involved. We, therefore investigated, whether GPCR-fAABs detectable in 31 patients suffering from Long-COVID-19 recovery disease. The spectrum was mostly (29/31 patients), including post-COVID-19 fatigue, alopecia, attention deficit, tremor others. Combined cardiovascular disorders were 17 patients. Two recovered free follow-up symptoms. All former had between 2 7 that acted as receptor agonists. Some those activate their target cause a positive chronotropic effect neonatal rat cardiomyocytes, read-out test system for detection (bioassay GPCR-fAAB detection). Other GPCR-fAABs, opposite, negative on cells. identified blood Long-COVID targeted β2-adrenoceptor (β2-fAAB), α1-adrenoceptor (α1-fAAB), angiotensin II AT1-receptor (AT1-fAAB), nociceptin-like opioid (NOC-fAAB). muscarinic M2-receptor (M2-fAAB), MAS-receptor (MAS-fAAB), ETA-receptor (ETA-fAAB). It analysed extracellular loops autoantibodies.

Language: Английский

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Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

Cells, Journal Year: 2020, Volume and Issue: 10(1), P. 51 - 51

Published: Dec. 31, 2020

The immune system plays a pivotal role in the initiation, development and resolution of inflammation following insult or damage to organs. heart is vital organ which supplies nutrients oxygen all parts body. Heart failure (HF) has been conventionally described as disease associated with cardiac tissue caused by systemic inflammation, arrhythmia conduction defects. Cardiac subsequent orchestrated infiltration activation various cells including neutrophils, monocytes, macrophages, eosinophils, mast cells, natural killer T B into myocardium. After injury, monocytes tissue-resident macrophages undergo marked phenotypic functional changes, function key regulators repair, regeneration fibrosis. Disturbance resident macrophage functions such uncontrolled production inflammatory cytokines, growth factors inefficient generation an anti-inflammatory response unsuccessful communication between epithelial endothelial fibroblasts can lead aberrant persistent HF. Therefore, this review, we discuss on

Language: Английский

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