Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents

JAMA Pediatrics, Journal Year: 2022, Volume and Issue: 176(10), P. 1000 - 1000

Published: Aug. 23, 2022

The postacute sequelae of SARS-CoV-2 infection (PASC) has emerged as a long-term complication in adults, but current understanding the clinical presentation PASC children is limited.To identify diagnosed symptoms, health conditions, and medications associated with children.This retrospective cohort study used electronic records from 9 US children's hospitals for individuals younger than 21 years who underwent antigen or reverse transcriptase-polymerase chain reaction (RT-PCR) testing between March 1, 2020, October 31, 2021, had at least 1 encounter 3 before testing.SARS-CoV-2 positivity by viral test (antigen RT-PCR).Syndromic (symptoms), systemic (conditions), medication features were identified 28 to 179 days following initial date. Adjusted hazard ratios (aHRs) obtained 151 clinically predicted contrasting test-positive groups test-negative using proportional hazards models, adjusting site, age, sex, location, race ethnicity, time period entrance. incidence proportion any syndromic, systemic, feature was estimated 2 obtain burden estimate.Among 659 286 sample, 348 091 (52.8%) male, mean (SD) age 8.1 (5.7) years. A total 59 893 (9.1%) tested positive SARS-CoV-2, 599 393 (90.9%) negative. Most outpatient facility settings (322 813 [50.3%]) office (162 138 [24.6%]). most common loss taste smell (aHR, 1.96; 95% CI, 1.16-3.32), myocarditis 3.10; 1.94-4.96), cough cold preparations 1.52; 1.18-1.96), respectively. 41.9% (95% 41.4-42.4) among vs 38.2% 38.1-38.4) children, an difference 3.7% 3.2-4.2). higher strength association those cared intensive care unit during acute illness phase, 5 years, complex chronic conditions.In this large-scale, exploratory study, pediatric that presented systems low. Myocarditis commonly PASC-associated condition. Acute severity, young comorbid disease increased risk PASC.

Language: Английский

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Damage to endothelial barriers and its contribution to long COVID

Angiogenesis, Journal Year: 2023, Volume and Issue: 27(1), P. 5 - 22

Published: April 27, 2023

Language: Английский

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Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19

Nature Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Unsupervised discovery of tissue architecture in multiplexed imaging

Nature Methods, Journal Year: 2022, Volume and Issue: 19(12), P. 1653 - 1661

Published: Oct. 31, 2022

Language: Английский

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Chest CT Findings in Hospitalized Patients with SARS-CoV-2: Delta versus Omicron Variants

Radiology, Journal Year: 2022, Volume and Issue: 306(1), P. 252 - 260

Published: June 28, 2022

Background CT manifestations of SARS-CoV-2 may differ among variants. Purpose To compare the chest findings between Delta and Omicron Materials Methods This retrospective study collected consecutive baseline images hospitalized patients with from a secondary referral hospital when variants were predominant. Two radiologists categorized according to RSNA classification system for COVID-19 visually graded pneumonia extent. Pneumonia, pleural effusion, intrapulmonary vessels segmented quantified on using priori–developed neural networks, followed by reader confirmation. Multivariable logistic linear regression analyses performed examine associations category, distribution, severity, peripheral vascularity. Results In total, 88 variant (mean age, 67 years ± 15 [SD]; 46 men) 62 19; 51 included. was associated less frequent, typical bilateral ground-glass opacity (32% [28 88] vs 57% [50 88], P = .001), more frequent peribronchovascular predilection (38% [25 66] 7% [five 71], < lower visual extent (5.4 6.0 7.7 6.6, .02), similar volume (5% 1 11, .14), higher proportion cross-sectional area smaller than 5 mm2 relative total pulmonary blood (BV5%; 48% 11 44% 8; .004). adjusted analyses, nontypical appearance (odds ratio, 0.34; .006), 9.2; BV5% (β 3.8; .01) but (P .17) .67) variant. Conclusion At CT, SARS-COV-2 showed vascular involvement did in disease severity. © RSNA, 2022 Online supplemental material is available this article.

Language: Английский

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Long-term mortality following SARS-CoV-2 infection: A national cohort study from Estonia

The Lancet Regional Health - Europe, Journal Year: 2022, Volume and Issue: 18, P. 100394 - 100394

Published: April 29, 2022

The objective of this study was to describe 12-month mortality following SARS-CoV-2 infection compared with a reference population no history SARS-CoV-2.Nationwide cohort using electronic health care data on RNA positive cases (n= 66,287) and group subjects (n=254,969) linkage testing death records.People infected SARS-COV-2 had more than three times the risk dying over year those who remained uninfected (aHR 3·1, 95%CI 2·9-3·3). Short-term (up 5 weeks post-infection) significantly higher among COVID-19 (1623·0/10 000) in (118/10 000). For aged 60 years or older, increased persisted until end first after infection, related for cardiovascular 2·1, 1·8-2·3), cancer 1·5, 1·2-1·9), respiratory system diseases 1·9, 1·2-3·0), other causes 1·8, 1·4-2·2).Increased from is not limited acute illness: carries substantially 12 months. This excess mainly occurs older people driven by broad array death.Research carried out support Estonian Research Council (grants PRG1197, PRG198), European Regional Development Fund (RITA 1/02-120) Social via IT Academy program.

Language: Английский

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The vascular perspective on acute and chronic lung disease

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(16)

Published: Aug. 14, 2023

The pulmonary vasculature has been frequently overlooked in acute and chronic lung diseases, such as respiratory distress syndrome (ARDS), fibrosis (PF), obstructive disease (COPD). primary emphasis the management of these parenchymal disorders largely revolved around injury aberrant repair epithelial cells. However, there is increasing evidence that vascular endothelium plays an active role development diseases. endothelial cell network capillary bed arterial venous vessels provides a metabolically highly barrier controls migration immune cells, regulates tone permeability, participates remodeling processes. Phenotypically functionally altered remodeled vessels, can be found although to different degrees, likely because disease-specific mechanisms. Since associated with hypertension, which worsens patient outcomes survival, it crucial understand underlying alterations. In this Review, we describe current knowledge regarding progression ARDS, PF, COPD; also outline future research directions hope facilitating mechanism-based therapies.

Language: Английский

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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 14, 2023

Abstract Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice cultured were used investigate how protein/S-RBD impacts endothelium. Results show that S-RBD leads acute-to-prolonged induction intracellular free calcium concentration ([Ca 2+ ] i ) via acute activation TRPV4, prolonged upregulation mechanosensitive channel Piezo1 store-operated (SOCC) key component Orai1 in human arterial (PAECs). mechanism, interacts with ACE2 induce formation clusters involving Orai1, TRPC1, facilitate SOCC, lead elevated apoptosis. These effects are blocked by Kobophenol A, which inhibits binding between ACE2, chelator, BAPTA-AM. Blockade SOCC GsMTx4 effectively protects S-RBD-induced microvascular damage hACE2 Tg normalizing [Ca . Comparing prototypic strain, Omicron variants (BA.5.2 XBB) less severe cell Transcriptomic analysis indicates confers more than Delta Lambda S-RBD. summary, study provides compelling evidence could persistent triggering through Orai1. Targeted inhibition ACE2-Piezo1/SOCC-[Ca axis proves a powerful strategy treat diseases.

Language: Английский

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Mechanisms of Pulmonary Vasculopathy in Acute and Long-Term COVID-19: A Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4941 - 4941

Published: April 30, 2024

Despite the end of pandemic, coronavirus disease 2019 (COVID-19) remains a major public health concern. The first waves virus led to better understanding its pathogenesis, highlighting fact that there is specific pulmonary vascular disorder. Indeed, COVID-19 may predispose patients thrombotic in both venous and arterial circulation, many cases severe acute embolism have been reported. demonstrated presence respiratory syndrome 2 (SARS-CoV-2) within endothelial cells suggests direct viral effects, addition indirect effects perivascular inflammation coagulopathy, contribute vasculopathy COVID-19. In this review, we discuss pathological mechanisms leading damage during infection, which appear be mainly related thromboembolic events, an impaired coagulation cascade, micro- macrovascular thrombosis, endotheliitis hypoxic vasoconstriction. As develop post-COVID symptoms, including dyspnea, also hypothesis hypertension as sequela involved pathophysiology long COVID.

Language: Английский

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Beyond the virus: ecotoxicological and reproductive impacts of SARS-CoV-2 lysate protein in C57Bl/6j female mice

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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