Biomedical Signal Processing and Control, Journal Year: 2025, Volume and Issue: 103, P. 107447 - 107447
Published: Jan. 6, 2025
Language: Английский
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 1857 - 1866
Published: July 1, 2023
Abstract Over 70,000 excess deaths occurred in Europe during the summer of 2003. The resulting societal awareness led to design and implementation adaptation strategies protect at-risk populations. We aimed quantify heat-related mortality burden 2022, hottest season on record Europe. analyzed Eurostat database, which includes 45,184,044 counts death from 823 contiguous regions 35 European countries, representing whole population over 543 million people. estimated 61,672 (95% confidence interval (CI) = 37,643–86,807) between 30 May 4 September 2022. Italy (18,010 deaths; 95% CI 13,793–22,225), Spain (11,324; 7,908–14,880) Germany (8,173; 5,374–11,018) had highest numbers, while (295 per million, 226–364), Greece (280, 201–355), (237, 166–312) Portugal (211, 162–255) rates. Relative population, we 56% more women than men, with higher rates men aged 0–64 (+41%) 65–79 (+14%) years, 80+ years (+27%). Our results call for a reevaluation strengthening existing heat surveillance platforms, prevention plans long-term strategies.
Language: Английский
Citations
487
Building and Environment, Journal Year: 2023, Volume and Issue: 234, P. 110133 - 110133
Published: Feb. 24, 2023
Urban populations face increasing heat stress in cities. However, the influence of built environment new and old urban blocks on pedestrian thermal comfort remains unclear. This study selected typical (Yongqingfang) areas (Knowledge City) Guangzhou, China, as our research sites. Through field monitoring surveys, we used physiological equivalent temperature (PET) vote (TCV) to evaluate outdoor by walk experiments. We analyzed relationships between variables, meteorological at two Our analysis revealed significant differences conditions within 60-m buffer zone. PET TCV showed noticeable spatiotemporal variations both sites, their correlation was stronger morning (r = 0.87–0.89) than late afternoon 0.60–0.70). stepwise regression model indicated that sky view factor building coverage ratio significantly affected blocks. Built variables explained a higher percentage variance (Yongqingfang R2: 0.59–0.82, Knowledge City 0.32–0.81) 0.45–0.57, 0.48–0.69). In short, indices more perception. The impact is also greater findings provide insights into complex relationship environments different landscapes, which informs climate-resilient design.
Language: Английский
Citations
57
Canadian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 39(9), P. 1182 - 1190
Published: April 6, 2023
Language: Английский
Citations
57
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(5), P. 1194 - 1205
Published: Feb. 2, 2024
Climate change is not just jeopardizing the health of our planet, but it increasingly impacting immune health.There an expanding body evidence that climaterelated exposures, such as air pollution, heat, wildfires, extreme weather events, and biodiversity loss significantly disrupt functioning human system.These exposures manifest in a broad range stimuli including antigens, allergens, heat stress, pollutants, microbiota changes, other toxic substances.Such pose direct indirect threat to body's primary line defense, epithelial barrier, affecting its physical integrity functional efficacy.Furthermore, these climate-related environmental stressors can hyper-stimulate innate system influence adaptive immunity, notably terms developing preserving tolerance.The or failure tolerance instigate wide spectrum non-communicable diseases autoimmune conditions, allergy, respiratory illnesses, metabolic diseases, obesity, others.As continues unravel, there need for additional research climate immunology covers diverse environments different global settings, employing modern biological epidemiological tools.
Language: Английский
Citations
24
Circulation, Journal Year: 2024, Volume and Issue: 149(16), P. 1298 - 1314
Published: April 15, 2024
Urban environments contribute substantially to the rising burden of cardiometabolic diseases worldwide. Cities are complex adaptive systems that continually exchange resources, shaping exposures relevant human health such as air pollution, noise, and chemical exposures. In addition, urban infrastructure provisioning influence multiple domains risk, including behaviors, psychological stress, nutrition through various pathways (eg, physical inactivity, heat food systems, availability green space, contaminant exposures). Beyond health, city design may also affect climate change energy material consumption share many same drivers with diseases. Integrated spatial planning focusing on developing sustainable compact cities could simultaneously create heart-healthy environmentally healthy designs. This article reviews current evidence associations between exposome (totality a person experiences, environmental, occupational, lifestyle, social, factors) within science framework, examines principles connectivity, density, diversity land use, destination accessibility, distance transit). We highlight critical knowledge gaps regarding built-environment feature thresholds for optimizing outcomes. Last, we discuss emerging models metrics align development dual goals mitigating while reducing cross-sector collaboration, governance, community engagement. review demonstrates represent crucial settings implementing policies interventions tackle global epidemics cardiovascular disease change.
Language: Английский
Citations
24
European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 31(6), P. 688 - 697
Published: Jan. 4, 2024
Abstract There is a growing recognition that the profound environmental changes have occurred over past century pose threats to human health. Many of these factors, including air pollution, noise as well exposure metals such arsenic, cadmium, lead, and other metals, are particularly detrimental cardiovascular health people living in low-to-middle income countries (LMICs). Low-to-middle likely be disproportionally burdened by diseases provoked factors. Moreover, they least capacity address core drivers consequences this phenomenon. This review summarizes impact factors climate change, metal on system, how specifically affect LMICs. It also outlines behaviour interventions reduce pollution would significant effects those from LMICs, globally.
Language: Английский
Citations
22
Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(2)
Published: Feb. 1, 2024
Health agencies recommend that homes of heat-vulnerable occupants (e.g., older adults) be maintained below 24-28°C to prevent heat-related mortality and morbidity. However, there is limited experimental evidence support these recommendations.
Language: Английский
Citations
22
Circulation Research, Journal Year: 2024, Volume and Issue: 134(9), P. 1048 - 1060
Published: April 25, 2024
Environmental stressors associated with human activities (eg, air and noise pollution, light disturbance at night) climate change heat, wildfires, extreme weather events) are increasingly recognized as contributing to cardiovascular morbidity mortality. These harmful exposures have been shown elicit changes in stress responses, circadian rhythms, immune cell activation, oxidative stress, well traditional risk factors hypertension, diabetes, obesity) that promote diseases. In this overview, we summarize evidence from animal studies of the impacts environmental on health. addition, discuss strategies reduce impact current future disease burden, including urban planning, personal monitoring, mitigation measures.
Language: Английский
Citations
22
Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550
Published: Feb. 27, 2025
Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.
Language: Английский
Citations
3
The Lancet, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
3