International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2894 - 2894
Published: March 1, 2024
Monocytes
are
associated
with
human
cardiovascular
disease
progression.
segregated
into
three
major
subsets:
classical
(cMo),
intermediate
(iMo),
and
nonclassical
(nMo).
Recent
studies
have
identified
heterogeneity
within
each
of
these
main
monocyte
classes,
yet
the
extent
to
which
subsets
contribute
heart
progression
is
not
known.
Peripheral
blood
mononuclear
cells
(PBMC)
were
obtained
from
61
subjects
Coronary
Assessment
Virginia
(CAVA)
Cohort.
atherosclerosis
severity
was
quantified
using
Gensini
Score
(GS).
We
employed
high-dimensional
single-cell
transcriptome
protein
methods
define
how
monocytes
differ
in
low
severe
coronary
artery
disease.
analyzed
487
immune-related
genes
49
surface
proteins
at
level
Antibody-Seq
(Ab-Seq).
six
myeloid
(cMo,
iMo,
nMo,
plasmacytoid
DC,
DC3)
based
on
proteins,
we
(CAD)
incidence
score
(GS)
subject.
Only
frequencies
iMo
high
CAD
(GS
>
32),
adj.p
=
0.024.
Spearman
correlation
analysis
GS
subject
revealed
a
positive
(r
0.314,
p
0.014)
further
showed
robust
sex-dependent
female
0.663,
0.004).
cMo
did
correlate
severity.
Key
gene
pathways
differed
among
between
males
females.
Further
PBMC,
distinguished
by
expression
HLA-DR,
CXCR3,
CD206.
found
that
frequency
immunoregulatory
iMo_HLA-DR+CXCR3+CD206+
(adj.p
0.006).
The
subset
positively
correlated
both
females
0.660,
0.004)
0.315,
0.037).
Cell
interaction
analyses
strong
interactions
CD4+
effector/memory
T
Tregs
same
subjects.
This
study
shows
importance
suggests
may
important
functional
roles
modulating
risk,
particularly
Med,
Journal Year:
2024,
Volume and Issue:
5(1), P. 10 - 31
Published: Jan. 1, 2024
Ischemic
heart
disease
is
the
greatest
health
burden
and
most
frequent
cause
of
death
worldwide.
Myocardial
ischemia/reperfusion
pathophysiological
substrate
ischemic
disease.
Improvements
in
prevention
treatment
have
reduced
mortality
developed
countries
over
last
decades,
but
further
progress
now
stagnant,
morbidity
from
developing
are
increasing.
Significant
problems
remain
to
be
resolved
require
a
better
understanding.
The
present
review
attempts
briefly
summarize
state
art
myocardial
research,
with
view
on
both
its
coronary
vascular
aspects,
define
cutting
edges
where
mechanistic
knowledge
needed
facilitate
translation
clinical
practice.
Intensive Care Medicine,
Journal Year:
2023,
Volume and Issue:
49(10), P. 1155 - 1167
Published: Sept. 7, 2023
Despite
significant
advancements
in
critical
care
medicine,
limited
attention
has
been
given
to
sex
and
gender
disparities
management
outcomes
of
patients
admitted
the
intensive
unit
(ICU).
While
"sex"
pertains
biological
physiological
characteristics,
such
as
reproductive
organs,
chromosomes
hormones,
"gender"
refers
more
sociocultural
roles
human
behavior.
Unfortunately,
data
on
gender-related
topics
ICU
are
lacking.
Consequently,
differences
admission
ICU,
clinical
course,
length
stay,
mortality,
post-ICU
burdens,
often
inconsistent.
Moreover,
when
examining
specific
diagnoses
variations
can
be
observed
epidemiology,
pathophysiology,
presentation,
severity,
treatment
response
due
distinct
impact
hormones
immune
cardiovascular
systems.
In
this
narrative
review,
we
highlight
influence
management,
most
encountered
conditions,
addition
potential
co-existence
unconscious
biases
which
may
also
illness.
Diagnoses
with
a
known
predilection
will
discussed
within
context
underlying
physiology,
anatomy,
pharmacology
goal
identifying
areas
where
improvement
is
needed.
To
optimize
patient
outcomes,
it
crucial
comprehend
address
setting
personalize
accordingly
ensure
equitable,
patient-centered
care.
Future
research
should
focus
elucidating
mechanisms
driving
disparities,
well
exploring
targeted
interventions
mitigate
these
improve
for
all
critically
ill
patients.
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(13)
Published: June 30, 2024
Biological
sex
is
an
important
modifier
of
physiology
and
influences
pathobiology
in
many
diseases.
While
heart
disease
the
number
one
cause
death
worldwide
both
men
women,
differences
exist
at
organ
cellular
scales,
affecting
clinical
presentation,
diagnosis,
treatment.
In
this
Review,
we
highlight
baseline
cardiac
structure,
function,
signaling
discuss
contribution
hormones
chromosomes
to
these
characteristics.
The
a
remarkably
plastic
rapidly
responds
physiological
pathological
cues
by
modifying
form
function.
nature
extent
remodeling
response
stimuli
are
often
dependent
on
biological
sex.
We
organ-
molecular-level
adaptive
from
pressure
volume
overload,
ischemia,
genetic
disease.
Finally,
offer
perspective
key
future
directions
for
research
into
differences.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0316130 - e0316130
Published: Jan. 10, 2025
Background
Previous
studies
have
shown
that
both
the
composite
dietary
antioxidant
index
(CDAI)
and
sex
are
strongly
associated
with
a
variety
of
cardiovascular
diseases,
but
differences
between
CDAI
hyperlipidemia
unknown.
Objective
This
study
utilized
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
to
investigate
hyperlipidemia.
Method
We
calculated
six
antioxidants
using
NHANES,
explored
relationship
prevalence
multivariate
logistic
regression
analysis,
analyzed
for
potential
nonlinear
associations
restricted
cubic
spline.
Finally,
association
was
further
in
different
genders.
Results
The
included
total
34,754
participants
mean
age
47.04
years,
whom
49.37%
were
man.
In
fully
adjusted
multivariable
binary
model,
negatively
(OR
=
0.99,
95%
CI:0.98–0.99).
addition,
highest
quartile
had
lower
risk
hyperlipidaemia
compared
lowest
0.83,
95%CI:
0.76–0.92).
also
found
non-linear
(non-linear
P
0.003,
Inflection
point
-0.179).
we
significantly
stronger
female
population
than
male
(P
interaction
<0.05).
Conclusion
Our
highlights
L-shaped
general
adult
population.
this
more
significant
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 24, 2025
Ischemic
heart
disease
(IHD)
remains
a
leading
cause
of
mortality
and
morbidity
globally.
This
study
aims
to
evaluate
the
trends
in
IHD
burden
across
different
socioeconomic
regions
using
data
from
Global
Burden
Disease
Study
2021
(GBD
2021)
understand
impact
metabolic
risk
factors
on
these
trends.
Data
GBD
was
analyzed
global
age-standardized
death
rates
(ASDR)
disability-adjusted
life
years
(ASRDALYs)
linked
IHD.
Key
evaluated
included
high
systolic
blood
pressure
(SBP),
low-density
lipoprotein
cholesterol
(LDLc),
fasting
plasma
glucose
(FPG),
body
mass
index
(BMI).
Temporal
were
assessed
estimated
annual
percentage
changes
(EAPCs),
with
further
analysis
by
age,
sex
socio-demographic
(SDI).
Resource-abundant
showed
notable
reductions
ASDR
ASRDALYs,
largely
due
effective
management
SBP
LDLc,
resulting
an
EAPC
-3.43
(95%
CI:
-3.32,
-3.53).
In
contrast,
resource-limited
regions,
particularly
among
males,
experienced
stagnation
or
even
increases
burden.
The
low-,
low-middle-,
middle-SDI
ranged
−
0.12
-0.04,
-0.19)
0.16
0.09,
0.23).
Among
values
0.22
0.14,
0.29)
0.55
0.47,
0.62).
increase
primarily
driven
rising
levels
FPG
BMI.
Younger
populations
(15–49
years)
disproportionately
affected,
showing
increasing
exposure
risks.
Regional
disparities
persist,
factors.
have
benefitted
control
whereas
face
growing
challenges,
especially
related
use
secondary
database
provides
comprehensive
perspective
but
may
not
fully
capture
local
variations
Targeted
public
health
strategies
early
interventions
are
essential
reduce
vulnerable
populations.
Mechanisms of Ageing and Development,
Journal Year:
2023,
Volume and Issue:
211, P. 111792 - 111792
Published: Feb. 17, 2023
Geroscience
puts
mechanisms
of
aging
as
a
driver
the
most
common
age-related
diseases
and
dysfunctions.
Under
this
perspective,
addressing
basic
will
produce
better
understanding
than
each
disease
pathophysiology
individually.
Worldwide,
despite
greater
functional
impairment,
life
expectancy
is
higher
in
women
men.
Gender
differences
prevalence
multimorbidity
lead
mandatory
to
underlying
gender-related
patterns
disability-free
expectancy.
Extensive
literature
suggested
that
inflammaging
at
crossroad
diseases.
In
review,
we
highlight
main
evidence
on
sex/gender
foster
inflammaging,
i.e.
age-dependent
triggering
innate
immunity,
modifications
adaptive
accrual
senescent
cells,
underpinning
some
biomarkers
show
sex-related
differences.
framework
"gender
medicine
perspective",
also
discuss
how
can
affect
sex
COVID-19
severe
outcomes.
