The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading significant morbidity mortality. The abnormality of immune response key factor in progression HF, contributing adverse cardiac remodeling dysfunction. Exosomal microRNAs (miRNAs) play pivotal role regulating gene expression cellular function, which are integral crosstalk between cells, influencing cell functions, such as macrophage polarization, T activity, cytokine production, thereby modulating various pathological processes inflammation, fibrosis, This review emphasizes immune-regulatory exosomal miRNAs HF highlights their clinical potential diagnostic biomarkers therapeutic agents.

Language: Английский

Cardio-Rheumatology: From Inflammation to Heart Failure. The Emerging Role of Cardiovascular Magnetic Resonance Imaging

Current Cardiovascular Imaging Reports, Journal Year: 2024, Volume and Issue: 18(1)

Published: Dec. 1, 2024

Language: Английский