Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: May 31, 2024
Abstract
The
immune
response
holds
a
pivotal
role
in
cardiovascular
disease
development.
As
multifunctional
cells
of
the
innate
system,
macrophages
play
an
essential
initial
inflammatory
that
occurs
following
injury,
thereby
inducing
subsequent
damage
while
also
facilitating
recovery.
Meanwhile,
diverse
phenotypes
and
phenotypic
alterations
strongly
associate
with
distinct
types
severity
diseases,
including
coronary
heart
disease,
valvular
myocarditis,
cardiomyopathy,
failure,
atherosclerosis
aneurysm,
which
underscores
importance
investigating
macrophage
regulatory
mechanisms
within
context
specific
diseases.
Besides,
recent
strides
single-cell
sequencing
technologies
have
revealed
heterogeneity,
cell–cell
interactions,
downstream
therapeutic
targets
at
higher
resolution,
brings
new
perspectives
into
macrophage-mediated
potential
Remarkably,
myocardial
fibrosis,
prevalent
characteristic
most
cardiac
remains
formidable
clinical
challenge,
necessitating
profound
investigation
impact
on
fibrosis
In
this
review,
we
systematically
summarize
functional
plasticity
diseases
unprecedented
insights
introduced
by
technologies,
focus
different
causes
characteristics
especially
relationship
between
inflammation
(myocardial
infarction,
pressure
overload,
dilated
diabetic
cardiomyopathy
aging)
vascular
injury
(atherosclerosis
aneurysm).
Finally,
highlight
preclinical/clinical
targeting
strategies
translational
implications.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
BMC Chemistry,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Jan. 3, 2025
This
study
investigates
the
phenolic
compounds
(PC),
volatile
(VC),
and
fatty
acids
(FA)
of
extra
virgin
olive
oil
(EVOO)
derived
from
Turkish
variety
"Sarı
Ulak",
along
with
ADMET,
DFT,
molecular
docking,
gene
network
analyses
significant
molecules
identified
within
EVOO.
Chromatographic
methods
(GC-FID,
HPLC)
were
employed
to
characterize
FA,
PC,
VC
profiles,
while
quality
parameters,
antioxidant
activities
(TAC,
ABTS,
DPPH)
assessed
via
spectrophotometry.
The
analysis
revealed
a
complex
composition
40
compounds,
estragole,
7-hydroxyheptene-1,
3-methoxycinnamaldehyde
as
primary
components.
Hydroxytyrosol,
tyrosol,
oleuropein,
apigenin,
ferulic
acid,
vanillic
acid
emerged
main
constituents,
hydroxytyrosol
apigenin
exhibiting
high
bioavailability.
Molecular
docking
highlighted
oleuropein
pinoresinol
strong
binding
affinities,
though
only
hydroxytyrosol,
fully
met
Lipinski
other
drug-likeness
criteria.
DFT
showed
that
have
notable
dipole
moments,
reflecting
polar
asymmetrical
structures.
KEGG
enrichment
further
linked
key
like
pathways
related
lipid
metabolism
atherosclerosis,
underscoring
their
potential
bioactivity
relevance
in
health-related
applications.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(2), P. 123 - 123
Published: Feb. 12, 2024
ApoB
is
the
main
protein
of
triglyceride-rich
lipoproteins
and
further
divided
into
ApoB48
in
intestine
ApoB100
liver.
Very
low-density
lipoprotein
(VLDL)
produced
by
liver,
contains
ApoB100,
metabolized
its
remnants,
intermediate-density
(IDL)
(LDL).
has
been
suggested
to
play
a
crucial
role
formation
atherogenic
plaque.
Apart
from
being
biomarker
atherosclerosis,
seems
be
implicated
inflammatory
process
atherosclerosis
per
se.
In
this
review,
we
will
focus
on
structure,
metabolism,
function
as
well
predictor
cardiovascular
risk.
Moreover,
elaborate
upon
molecular
mechanisms
regarding
pathophysiology
discuss
disorders
associated
with
APOB
gene
mutations,
potential
various
drugs
therapeutic
targets.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
The
presence
of
a
substantial
necrotic
core
in
atherosclerotic
plaques
markedly
heightens
the
risk
rupture,
consequence
elevated
iron
levels
that
exacerbate
oxidative
stress
and
lipid
peroxidation,
thereby
sustaining
detrimental
cycle
ferroptosis
inflammation.
Concurrently
targeting
both
inflammation
is
crucial
for
effective
treatment
vulnerable
plaques.
In
this
study,
we
introduce
gallium
hexacyanoferrate
nanoabsorption
catalysts
(GaHCF
NACs)
designed
to
disrupt
pathological
cycle.
GaHCF
NACs
function
as
highly
efficient
chelators
with
robust
antiferroptosis
properties.
Through
situ
capture
within
plaques,
these
enhance
reactive
oxygen
species
scavenging,
initiating
an
amplified
therapeutic
response.
significantly
advance
plaque
regression,
stabilization,
vascular
functional
recovery
by
inhibiting
MAPK13
(p38-δ
MAPK)
signaling,
key
mediator
cell
death.
Importantly,
process
generates
detectable
photoacoustic
signal,
offering
notable
diagnostic
advantage
allows
real-time
monitoring
plague
status.
This
multifunctional
nanocatalytic
platform
transforms
toxic
into
agent,
adapting
dynamically
microenvironment
representing
promising
strategy
reducing
vulnerability
preventing
rupture.
