Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 158 - 187

Published: Dec. 28, 2024

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, molecular mechanisms underlying CVDs not yet fully understood. For decades, protein-coding genes have been focus CVD research. However, recent genomics highlighted importance long non-coding RNAs (lncRNAs) cardiovascular health disease. Changes lncRNA expression specific tissues may result from various internal or external factors, tissue damage, organ dysfunction, In this review, we provide a comprehensive discussion regulatory lncRNAs their roles pathogenesis progression CVDs, such as coronary heart disease, atherosclerosis, failure, arrhythmias, cardiomyopathies, diabetic cardiomyopathy, explore potential therapeutic targets diagnostic biomarkers.

Language: Английский