Mitochondrial Calcium Homeostasis and Atrial Fibrillation: Mechanisms and Therapeutic Strategies Review

Current Problems in Cardiology, Journal Year: 2025, Volume and Issue: 50(3), P. 102988 - 102988

Published: Jan. 17, 2025

Language: Английский

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Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

Circulation, Journal Year: 2024, Volume and Issue: 150(7), P. 544 - 559

Published: June 24, 2024

Alterations in the buffering of intracellular Ca

Language: Английский

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Obesity modifies the association between abnormal glucose metabolism and atrial fibrillation in older adults: A community-based longitudinal and prospective cohort study

Hellenic Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

To investigate the modifying role of obesity in association between abnormal glucose metabolism and atrial fibrillation (AF) risk older individuals. From April 2007 to November 2011, 11663 participants aged ≥60 years were enrolled Shandong area. Glucose metabolic status determined using fasting plasma hemoglobin A1c levels, body mass index (BMI), waist-to-hip ratio (WHR), visceral fat area (VFA). Obesity-associated activities assessed adiponectin-to-leptin (ALR), galectin-3, triglyceride-glucose (TyG). New-onset AF was diagnosed by ICD-10. During an average 11.1 follow-up, 1343 developed AF. risks higher those with prediabetes, uncontrolled diabetes, well-controlled diabetes than normoglycemia. The hazard ratios decreased 14.79%, 40.29%, 25.23% 31.44%, 53.56%, 41.90% 21.16%, 42.38%, 27.59% after adjusting for BMI, WHR, VFA, respectively. population attributable percentage general obesity, central high VFA new-onset 10.43%, 34.78%, 31.30%, ALR, TyG significantly mediated (all Padj. <0.001). Obesity mediates WHR is effective modifier BMI moderating association. TyG, galectin-3 mediate effect on risk.

Language: Английский

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Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity

JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Metabolic dysfunction associated steatotic liver disease is associated with atrial fibrillation recurrence following cryoballoon ablation

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 21, 2025

Atrial fibrillation (AF) is a common arrhythmia often treated with cryoballoon ablation. The impact of Metabolic-associated fatty liver disease (MASLD), condition newly defined by index ≥ 60, on AF recurrence post-ablation unclear. We analyzed 303 patients undergoing ablation for AF. Cox proportional hazards models were used to assess the relationship between MASLD and recurrence. Paroxysmal atrial was present in 61.1% 63% male. Among patients, 23.4% had MASLD. These exhibited larger left diameter ventricular end-diastolic dimension. During median follow-up 14 months, more frequent (45.1% vs. 20.7%). independently predicted (HR, 2.24 [95% CI 1.35–3.74], P = 0.002), alongside persistent AF, longer duration, diameter. consistently demonstrated significant association an increased risk both paroxysmal 2.38 CI, 1.08–5.23], 0.031) 2.55 1.23–5.26], 0.011). significantly increases after ablation, highlighting importance supporting targeted interventions periprocedural management

Language: Английский

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Decreased METTL3 in atrial myocytes promotes atrial fibrillation

EP Europace, Journal Year: 2025, Volume and Issue: 27(2)

Published: Feb. 1, 2025

Abstract Aims Methyltransferase like 3 (METTL3) plays a crucial role in cardiovascular diseases, but its involvement atrial fibrillation (AF) remains unclear. The study aims to explore the relationship between METTL3 and AF myocytes. Methods results protein level of was evaluated left appendages (LAAs) from patients with persistent experimental models. cAMP-responsive element modulator (CREM) transgenic mice CaCl2-acetylcholine (ACh)-injected were used as globally conditionally deleted vivo assess AF. Confocal fluorescence microscopy employed examine calcium handling Methylated RNA immunoprecipitation sequencing performed identify downstream target genes METTL3. N6-methyladenosine (m6A) modification levels significantly reduced LAAs Genetic inhibition promoted development CREM CaCl2-ACh-injected mice. Knockdown myocytes resulted enhanced handling. Reduced increased SR Ca2+-ATPase Type 2a activity by up-regulating protocadherin gamma subfamily A, 10. Decreased attributed down-regulation element-binding 1/ubiquitin-specific peptidase 9 X-linked axis. Conclusion Our established pathophysiological involved provided potential mechanism-based for treatment.

Language: Английский

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Unique Treatment of Atrial Fibrillation: Simultaneous Dual Direct-Current Cardioversion in Morbidly Obese Patients

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Atrial fibrillation (AFib) is a prevalent arrhythmia associated with substantial health complications and economic strain on the care system in United States. Obesity challenging comorbidity to manage this scenario, as incidence of AFib rises alongside increasing body mass index (BMI). Furthermore, obesity presents several challenges applying traditional treatment modalities for AFib, such pharmacological options, ablation, direct-current cardioversion (DCCV). Currently, there no specific regimen treating morbidly obese patients. This case report describes discusses unique option patient poorly controlled AFib. A 43-year-old male comorbidities including morbid BMI 87 kg/m2 presented setting sepsis bacteremia. The was treated doses metoprolol without effective control his had previously received amiodarone well appropriate response. DCCV performed under deep sedation using dexmedetomidine propofol infusions careful attention maintaining spontaneous ventilation. successfully converted normal sinus rhythm dual biphasic (each at 200 J). Pharmacological can be population due medications being less BMI. anesthetic plan important consideration case, given risk obstruction potential airway compromise. Nasal continuous positive pressure use supported patency maintained respirations while ensuring adequate depth anesthesia. Morbidly patients likely require increased energy cardioversion; thus, we describe effectiveness simultaneous two sets pads after an unsuccessful single shock J.

Language: Английский

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Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 24, 2025

The triglyceride–glucose (TyG) index, an emerging surrogate marker of insulin resistance, has been implicated in adverse cardiovascular outcomes. However, its prognostic value critically ill patients with atrial fibrillation (AF) remains unclear. This study aimed to investigate the association between TyG index and all-cause mortality this high-risk population. We identified AF from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into tertiles based on their levels. primary outcome was 30-day mortality, 90-day 365-day as secondary Cox proportional hazards regression analysis restricted cubic splines were used elucidate relationship mortality. Kaplan–Meier survival performed visualize differences among tertiles. A total 1473 included; 30-day, 90-day, rates 26.8%, 33.3%, 41.1%, respectively. Multivariate revealed that independently associated at 30 days [hazard ratio (HR) (95% confidence interval (CI)) 1.26 (1.09–1.45), P = 0.002], 90 [HR CI) 1.27 (1.11–1.45), < 0.001], 365 1.24 (1.10–1.40), 0.001]. Restricted showed a positive linear risk. curves further confirmed significant disparities across observed higher increased 30, 90, AF. underscores role key indicator risk stratification management intensive care.

Language: Английский

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Metabolic dysfunction-associated steatotic liver disease and increased risk of atrial fibrillation in the elderly: A longitudinal cohort study

IJC Heart & Vasculature, Journal Year: 2025, Volume and Issue: 58, P. 101676 - 101676

Published: April 8, 2025

Language: Английский

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Cardiac Oxygen Consumption in Atrial Fibrillation: A Heart Out of Breath

American Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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