Luminal Flow in the Connecting Tubule induces Afferent Arteriole Vasodilation DOI Creative Commons
Hong Wang, Pablo A. Ortiz, César A. Romero

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Background Renal autoregulatory mechanisms modulate renal blood flow. Connecting tubule glomerular feedback (CNTGF) is a vasodilator mechanism in the connecting (CNT), triggered paracrinally when high sodium levels are detected via epithelial channel (ENaC). The primary activation factor of CNTGF—whether NaCl concentration, independent luminal flow, or combined total delivery—is still unclear. We hypothesized that increasing flow CNT induces CNTGF O2 - generation and ENaC activation. Methods Rabbit afferent arterioles (Af-Arts) with adjacent CNTs were microperfused ex-vivo variable rates concentrations ranging from <1 mM to 80 5 40 nL/min rates. Results Perfusion 10, 20, caused rate-dependent dilation Af-Art (p<0.001). Adding blocker benzamil inhibited flow-induced dilation, indicating response. In contrast, perfusion did not result vasodilation (p>0.05). Multiple linear regression modeling (R 2 =0.51;p<0.001) demonstrated tubular (β=0.163 ± 0.04;p<0.001) concentration (β=0.14 0.03;p<0.001) variables induce arteriole vasodilation. Tempol reduced CNTGF, L-NAME influence this effect. Conclusion Increased ENaC, partially due flow-stimulated O2-production nitric oxide synthase (NOS) activity.

Language: Английский

Transient receptor potential melastatin 7 cation channel, magnesium and cell metabolism in vascular health and disease DOI
Belma Melda Abidin, Francisco J. Rios, Augusto C. Montezano

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 12, 2025

Abstract Preserving the balance of metabolic processes in endothelial cells (ECs) and vascular smooth muscle (VSMCs), is crucial for optimal function integrity. ECs are metabolically active depend on aerobic glycolysis to efficiently produce energy their essential functions, which include regulating tone. Impaired EC metabolism linked damage, increased permeability inflammation. Metabolic alterations VSMCs also contribute dysfunction atherosclerosis hypertension. Magnesium (Mg 2+ ) second most abundant intracellular divalent cation influences molecular that regulate function, including vasodilation, vasoconstriction, release vasoactive substances. Mg critically involved maintaining cellular homeostasis since it an cofactor ATP, nucleic acids hundreds enzymes processes. Low levels have been dysfunction, tone, inflammation arterial remodeling. Growing evidence indicates important role transient receptor potential melastatin‐subfamily member 7 (TRPM7) channel regulation VSMCs. In vasculature, TRPM7 deficiency leads impaired contraction, phenotypic switching VSMCs, fibrosis, characterize phenotype Here we provide a comprehensive overview TRPM7/Mg how VSMC such as glucose homeostasis, redox regulation, phosphoinositide signaling, mineral metabolism. The putative altered hypertension discussed.

Language: Английский

Citations

2
Relationship between oxidative balance score and all-cause mortality in hypertension DOI Creative Commons
Tianyi Ma, Ling Wang,

Xiaorong Yan

et al.

Journal of Vascular Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Jan. 17, 2025

Exploring the association between oxidative balance score (OBS) and all-cause mortality in hypertension (HTN). Data for HTN patients from 2007 to 2018 were extracted National Health Nutrition Examination Survey (NHANES). OBS offers a thorough evaluation of an individual's redox status, with higher indicates favorable homeostasis. All-cause was obtained by linkage Death Index records through 31 December 2019. Weighted multivariable Cox regression models, Kaplan-Meier curves, receiver operator characteristic (ROC) curve, random survival forests (RSF) analysis applied examine relationship HTN. The cohort included 13,130 participants, 2,132 deaths. Higher associated lower risk (HR=0.77, 95%CI: 0.65-0.91) also existed subgroups male, having/haven't chronic kidney disease, having cardiovascular disease. curves suggested that participants had superior rates compared those intake. RSF showed better predictive role physical activity among components OBS. related odds Adopting healthy lifestyle consuming antioxidant-rich diet may improve prognosis

Language: Английский

Citations

1
Sericin-based conductive hydrogel loaded with MXene@TA-Eu nanosheets promotes the healing of infected wounds through photothermal antibacterial and electrical stimulation DOI

Chuankai Zhang,

Peirong Zhou,

Ye Deng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159738 - 159738

Published: Jan. 1, 2025

Language: Английский

Citations

1
Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases DOI Creative Commons
Cláudia Penna, Pasquale Pagliaro

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 256 - 256

Published: Feb. 23, 2025

Endothelial dysfunction (ED) is characterized by an imbalance between vasodilatory and vasoconstrictive factors, leading to impaired vascular tone, thrombosis, inflammation. These processes are critical in the development of cardiovascular diseases (CVDs) such as atherosclerosis, hypertension ischemia/reperfusion injury (IRI). Reduced nitric oxide (NO) production increased oxidative stress key contributors ED. Aging further exacerbates ED through mitochondrial oxidative/nitrosative stress, heightening CVD risk. Antioxidant systems like superoxide-dismutase (SOD), glutathione-peroxidase (GPx), thioredoxin/thioredoxin-reductase (Trx/TXNRD) pathways protect against stress. However, their reduced activity promotes ED, vulnerability IRI. Metabolic syndrome, comprising insulin resistance, obesity, hypertension, often accompanied Specifically, hyperglycemia worsens endothelial damage promoting Obesity leads chronic inflammation changes perivascular adipose tissue, while associated with increase The NLRP3 inflammasome plays a significant role being triggered factors reactive oxygen nitrogen species, ischemia, high glucose, which contribute inflammation, injury, exacerbation Treatments, N-acetyl-L-cysteine, SGLT2 or inhibitors, show promise improving function. Yet complexity suggests that multi-targeted therapies addressing metabolic disturbances essential for managing CVDs syndrome.

Language: Английский

Citations

1
Role of Oxidative Balance Score in Staging and Mortality Risk of Cardiovascular-Kidney-Metabolic Syndrome: Insights from Traditional and Machine Learning Approaches DOI Creative Commons
Yang Chen, Shuang Wu, Hongyu Liu

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103588 - 103588

Published: March 7, 2025

To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk cardiovascular-kidney-metabolic syndrome (CKM). Data this study were from National Health Nutrition Examination Survey 1999-2018. We performed cross-sectional analyses using multinomial logistic regression to investigate relationship between OBS CKM staging. Cox proportional hazards models used assess impact on outcomes patients. Additionally, mediation explore whether mediated relationships specific predictors (Life's Simple 7 [LS7], systemic immune-inflammation index [SII], frailty score) outcomes. Then, machine learning developed classify stages 3/4 predict all-cause mortality, with SHapley Additive exPlanations values interpret contribution components. 21,609 participants included (20,319 CKM, median [IQR] age: 52.0 [38.0-65.0] years, 54.3% male, follow-up: 9.4 [5.3-14.1] years). Lower quartiles associated advanced Moreover, lower related increased risk, compared Q4 (all-cause mortality: Q1: HR 1.31, 95% CI 1.18-1.46, Q2: 1.27, 1.14-1.42, Q3: 1.18, 1.06-1.32; cardiovascular 1.44, 1.16-1.79, 1.39, 1.11-1.74, 1.26, 1.01-1.57; non-cardiovascular 1.12-1.44, 1.23, 1.08-1.40, 1.16, 1.02-1.31), optimal stratification threshold for was 22. (ranging 4.25%-32.85 %) effects SII, LS7, scores light gradient boosting achieved highest performance predicting (area under curve: 0.905) 0.875). Cotinine while magnesium, vitamin B6, physical activity protective. This highlights as a tool emphasizing stress's role management.

Language: Английский

Citations

1
The Aging Heart in Focus: The Advanced Understanding of Heart Failure with Preserved Ejection Fraction DOI

Zhe-Wei Zhang,

Yibin Wang, Xiangqi Chen

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102542 - 102542

Published: Oct. 12, 2024

Language: Английский

Citations

4
Luminal flow in the connecting tubule induces afferent arteriole vasodilation DOI
Hong Wang, Pablo A. Ortiz, César A. Romero

et al.

Clinical and Experimental Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Language: Английский

Citations

0
An Endothelium‐Mimicking, Healable Hydrogel Shield for Bioprosthetic Heart Valve with Enhanced Intravascular Biocompatibility DOI Open Access

Miribani Maitusong,

Tanchen Ren, Ying Gao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Bioprosthetic heart valves (BHVs) for transcatheter replacement often face deterioration due to thrombosis, inflammation, and calcification, which are irreversible. Here, a multidimensional endothelium‐mimicking healable hydrogel shielded BHV that not only withstand the complex valvular physiological hemodynamic environment but also able reverse damage‐induced structural degeneration by in situ healing is proposed. Polydopamine/selenocystamine nanoparticles with photothermal effect embedded achieve light‐triggered catalytic nitride oxide generation polyvinyl alcohol coating on surface. Additionally, platelet inhibitor Tirofiban encapsulated shield block acute coagulation cascade early stage after implantation. A rodent intravascular leaflet‐like implantation model developed reveal long‐term hemocompatibility of BHVs abdominal aorta. The exhibit enhanced antithrombotic properties, reduced superior endothelialization, improved vascular patency. Transcriptome analysis indicates better endothelial functions BHVs. Moreover, maintains both mechanical properties biological healing, facilitated great fast re‐endothelialization. Collectively, strategy provides new insight preventing reversing damage instead solely replacement.

Language: Английский

Citations

0
Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link? DOI Open Access

Francesca Picone,

Valentina Giudice, Concetta Iside

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 868 - 868

Published: Jan. 21, 2025

Cardiometabolic and cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with well-established risk factors such as smoking, obesity, diabetes contributing to plaque formation chronic inflammation. However, emerging evidence suggests that immune system plays a more significant role in development progression CVD than previously thought. Specifically, finely tuned regulation lymphocyte subsets governs post-injury inflammation tissue damage resolution orchestrates functions activation endothelial cells, cardiomyocytes, fibroblasts CVD-associated lesions (e.g., atherosclerotic plaques). A deeper understanding system’s involvement will provide new insights into disease biology uncover novel therapeutic targets aimed at re-establishing homeostasis. In this review, we summarize current state knowledge on distribution CVD, including atherosclerosis, diabetes, hypertension, myocardial infarction, stroke.

Language: Английский

Citations

0
Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population DOI Creative Commons
Chen Chen, Hanzhang Wu, Hongyu Jin

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Background This study investigates the joint effect of sleep patterns and oxidative balance score (OBS) on all-cause CVD mortality in general population. Methods We examined 21,427 individuals aged 18–85 from NHANES 2005–2014, connecting them to data until December 31, 2019, using interview physical examination dates. Surveys collected duration, self-reported disturbance, doctor-told disorders, classified into healthy, intermediate, unhealthy patterns. OBS was calculated based twenty stress-related exposures dietary lifestyle factors. Cox proportional hazards model conducted evaluate association between or alone combined with mortality. Results Poor pro-oxidant (Q1 &amp; Q2) were identified as risk factors for Each point increase associated a 3% decrease both There an interaction (P = 0.013). Joint analyses revealed that participants (intermediate poor) pattern significantly increased (HR 1.45 [1.21–1.74]) 1.60 [1.12–2.28]). Furthermore, stratified analysis highlighted this more prominent among without hypertension diabetes; notable younger elderly. Conclusion significant affecting Unhealthy jointly positively Interventions targeting healthy antioxidant lifestyles may promote health outcomes.

Language: Английский

Citations

0