Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: 21, P. 100929 - 100929

Published: Jan. 9, 2025

Language: Английский

Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial

Heart, Journal Year: 2025, Volume and Issue: unknown, P. heartjnl - 324925

Published: March 6, 2025

Epicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it associated coronary artery disease, little known regarding its role aortic stenosis. We sought to investigate association of epicardial stenosis severity and progression, myocardial remodelling function, mortality asymptomatic patients In post hoc analysis 124 mild-to-severe participating prospective clinical trial, baseline was quantified on CT angiography using fully automated deep learning-enabled software. Aortic disease assessed at 1 year. The primary endpoint all-cause mortality. Neither volume nor attenuation correlated or subsequent progression as by echocardiography (p>0.05 for all). plasma cardiac troponin concentration (r=0.23, p=0.009), mass (r=0.46, p<0.001), ejection fraction (r=-0.28, p=0.002), global longitudinal strain (r=0.28, p=0.017), atrial (r=0.39, p<0.001). During median follow-up 48 (IQR 26-73) months, total 23 (18%) died. multivariable analysis, both (HR 1.82, 95% CI 1.10 3.03; p=0.021) 1.47, 1.13 1.90; p=0.004) were mortality, after adjustment age, body index fraction. Patients >90 mm3 had 3-4 times higher risk death (adjusted HR 3.74, 1.08 12.96; p=0.037). does not associate but correlate blood imaging biomarkers impaired health. latter may explain an increased gov (NCT02132026).

Language: Английский

Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3071 - 3071

Published: April 29, 2025

Aortic aneurysms (AAs), the dilation or widening of aorta, lead to dissection rupture with high morbidity and mortality if untreated. AA displays gender disparities in its prevalence, progression outcomes, women having worse outcomes faster aneurysm growth. However, current guidelines do not address dimorphism, emphasizing urgent need for personalized treatment strategies further research. Perivascular adipose tissue (PVAT), a unique type fat surrounding blood vessels, plays critical role maintaining vasomotor tone vascular homeostasis, dysfunction associated chronic inflammation vessel-wall remodeling. Indeed, PVAT promotes development aortic aneurysms, hormonal biomechanical factors exacerbating pathological microenvironment. The sexually dimorphic characteristics include morphological, immunological, hormonally mediated differences. Thus, targeting PVAT-mediated mechanisms may be promising option (gender-specific) therapeutic management cardiovascular pathologies. This review examines emerging importance health, potential implications AA, identifies gaps state

Language: Английский