Biomimetic design strategies for biomedical applications DOI Creative Commons
Xinwei Wei, Yanfang Wang, Yun Liu

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 826 - 854

Published: Jan. 22, 2024

Language: Английский

Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis DOI Creative Commons
Shoupeng Cao, Tsvetomir Ivanov,

Julian Heuer

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless organelles. Their biomimetic properties, such molecular crowding selective partitioning, make them promising components for designing cell-like materials. However, their use artificial has been limited by complex structure, control over internal microenvironment inherent colloidal instability. Here we report the design dipeptide coacervates that exhibit enhanced stability, biocompatibility, hydrophobic microenvironment. The character facilitates encapsulation species, including transition metal-based catalysts, enhancing efficiency in aqueous environments. Dipeptide carrying catalyst are incorporated active cells trigger an chemical reaction. development with opens alternative avenue field materials applications catalysis synthetic biology.

Language: Английский

Citations

47
Liquid spherical shells are a non-equilibrium steady state of active droplets DOI Creative Commons

Alexander M. Bergmann,

Jonathan Bauermann, Giacomo Bartolucci

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 17, 2023

Liquid-liquid phase separation yields spherical droplets that eventually coarsen to one large, stable droplet governed by the principle of minimal free energy. In chemically fueled separation, formation phase-separating molecules is coupled a fuel-driven, non-equilibrium reaction cycle. It thus dissipative structures sustained continuous fuel conversion. Such are ubiquitous in biology but poorly understood as they thermodynamics. Here, we bridge gap between passive, close-to-equilibrium, and active, with separation. We observe spherical, active can undergo morphological transition into liquid, shell. demonstrate mechanism related gradients short-lived material. characterize how far out equilibrium shell state chemical power necessary sustain it. Our work suggests alternative avenues for assembling complex morphologies, which might already be exploited form membraneless organelles cells.

Language: Английский

Citations

46
Stimuli-responsive peptide hydrogels for biomedical applications DOI

Haoran Zhou,

Yanhua Zhu,

Bingbing Yang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1748 - 1774

Published: Jan. 1, 2024

This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications.

Language: Английский

Citations

37
Colorimetric sensing for translational applications: from colorants to mechanisms DOI
Zhicheng Jin, Wonjun Yim, Maurice Retout

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7681 - 7741

Published: Jan. 1, 2024

This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.

Language: Английский

Citations

37
Biomimetic design strategies for biomedical applications DOI Creative Commons
Xinwei Wei, Yanfang Wang, Yun Liu

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 826 - 854

Published: Jan. 22, 2024

Language: Английский

Citations

33