Molecular Tweezers for Biomimetic Recognition of Carbohydrates

ChemBioChem, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Molecular recognition of biomolecules by means synthetic receptors is a key topic with several potential applications, which must face the challenge recognizing relatively large guests in an aqueous medium. Due to their open cavity, molecular tweezers are promising architectures for this purpose that have already shown interesting properties lipids, nucleic acids, and proteins, thereby eliciting biological activities. Carbohydrates, assembled within glycans, polar high structural complexity particularly difficult be effectively recognized water. Notably, addition reports on more widely explored structures, significant advances been achieved exploiting peculiarity tweezer receptors. In review selection some emblematic examples from literature tweezers, cleft clips targeting carbohydrates presented, together discussion advantages limitations type architecture.

Language: Английский

Controlled Assembly of [3+6] and [4+8] Porous Organic Cages for Rapid Removal of Iodide from Water

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Comprehensive Summary Research into controlling the self‐assembly of discrete porous organic cages (POCs) with specific geometries and functions is difficult, but important for understanding their structure‐property relationship, as well behavior in supramolecular chemistry. Herein, we report two POCs based on same tetraformyl‐functionalized calix[4]resorcinarene (C4RACHO) 2,4‐diaminophenol dihydrochloride (DAP) building blocks, including a [3+6] triangular prism ( CPOC‐201‐OH ) [4+8] square CPOC‐401‐OH ), determined by single X‐ray crystallographic analysis. Both exhibit large intrinsic cavities, rich oxygen sites, high porosity Brunauer–Emmett–Teller (BET) surface areas up to 966 m 2 ·g –1 . Owing such virtues, both can effectively capture iodine aqueous media removal rate > 99% within min.

Language: Английский

Transforming Carbohydrates Through Multicomponent Reactions: Advances and Applications

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract This review highlights multicomponent reactions (MCRs) and their utilization in carbohydrate chemistry, where the anomeric center remains a concerning point maintaining selectivity is major challenge. Successful examples included involve synthesis of multifunctional carbohydrates with enhanced inherent physicochemical biological properties. compiles presents importance MCR which parent structure modified intact. explores various types MCRs applied to carbohydrates, highlighting synthesis, derivatization, functionalization molecules. The mechanistic aspects these highlight how unique structural features influence reaction pathways outcomes. applications fields glycomics glycoproteomics are shown, extension probability also discussed here. Through this comprehensive review, we provide insights into current state art identify promising future research directions that could further enhance utility impact chemical sciences. reader will be inspired perform for complex molecule expand use materials science.

Language: Английский