Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

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PET‐Based Dual‐Modal Probes for In Vivo Imaging

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Molecular imaging has significantly advanced the detection and analysis of in vivo metabolic processes, while single‐modal techniques remain limited. Dual‐modal imaging, particularly positron emission tomography (PET)‐based combinations emerged as a powerful solution, offering enhanced capabilities through integration with magnetic resonance (MRI) or near‐infrared fluorescence (NIRF) imaging. This review highlights recent progress PET‐based dual‐modal focusing on development various bimodal probes derived from antibodies, nanoparticles, peptides, key applications including image‐guided surgery disease assessment. holds substantial potential for advancing research diagnostics by improving resolution providing functional insights. By combining complementary modalities, these systems deliver more comprehensive view leading to accurate diagnoses targeted treatments. Future prioritizes optimizing probe design biocompatibility safety, facilitating clinical translation, broadens beyond cancer. Through interdisciplinary collaboration, are poised play pivotal role patient outcomes, diagnosing managing complex diseases.

Language: Английский

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An Acceptor–Donor–Acceptor Structured Nano‐Aggregate for NIR‐Triggered Interventional Photoimmunotherapy of Cervical Cancer

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (

Language: Английский

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Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

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A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160178 - 160178

Published: Jan. 1, 2025

Language: Английский

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Molecularly Engineered NIR-II Emitting Carbon Dots Assemblies for Unprecedented High-Resolution Angiography and Synergistic Photodynamic/Photothermal Tumor Therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159356 - 159356

Published: Jan. 7, 2025

Language: Английский

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Recent advances in low‐background luminescent nanomaterials‐enhanced lateral flow assays for clinical diagnosis

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.

Language: Английский

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Facile Labeling of Gram-Negative Bacteria with NIR-II Fluorescent Nanoprobes for Intestinal Bacteria Imaging

ACS Omega, Journal Year: 2025, Volume and Issue: 10(2), P. 2044 - 2050

Published: Jan. 7, 2025

The gut bacteria not only play a crucial role in maintaining human health but also exhibit close associations with the occurrence of numerous diseases. Understanding physiological and pathological functions enabling early diagnosis diseases heavily relies on accurate knowledge about their vivo distribution. Consequently, there is significant demand for noninvasive imaging techniques capable providing real-time localization information regarding bacteria. In this work, we developed second near-infrared (NIR-II) fluorescent nanoprobe labeling-based visualization strategy tracking biodistribution Gram-negative gastrointestinal tract mice. By utilizing positively charged silver sulfide quantum dots (Ag2S QDs) as NIR-II nanoprobes exploiting electrostatic interactions to efficiently label probiotic Escherichia coli Nissle 1917 negative surface charges, have achieved rapid effective labeling. Leveraging exceptional performance Ag2S QDs, our approach enables high spatiotemporal resolution via mouse areas where QD-labeled probiotics are present, facilitating capabilities these labeled probiotics. This work establishes powerful intestinal bacterial introduces novel concepts constructing nanomaterial-bacteria hybrid systems.

Language: Английский

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Advances in prostate-specific membrane antigen-targeted theranostics: from radionuclides to near-infrared fluorescence technology

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Prostate-Specific Membrane Antigen (PSMA) is a highly expressed and structurally unique target specific to prostate cancer (PCa). Diagnostic therapeutic approaches in nuclear medicine, coupling PSMA ligands with radionuclides, have shown significant clinical success. PSMA-PET/CT effectively identifies tumors metastatic lymph nodes for imaging purposes, while 177Lu-PSMA-617 (Pluvicto) has received FDA approval treating castration-resistant PCa (mCRPC). Despite their success, radionuclide-based diagnostic methods face limitations such as high costs side effects. Recently, near-infrared (NIR) fluorescence phototherapy advanced significantly biomedical applications. It's benefits, deep tissue penetration, real-time precision, minimal effects, driven broader adoption, especially fluorescence-guided surgery (FGS). This review suggests combining NIR dyes enable targeted, high-resolution superior signal-to-background ratios, facilitating precise FGS. techniques can also aid pathological diagnosis ex vivo specimens. Furthermore, photosensitizers allows localized photothermal (PTT) or photodynamic therapy (PDT) under irradiation, producing heat reactive oxygen species (ROS) treat PCa. aims extend the success of targeting by exploring advances NIR-based FGS phototherapy, presenting promising new approach.

Language: Английский

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