Trends in cancer, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
npj Precision Oncology, Journal Year: 2025, Volume and Issue: 9(1)
Published: March 29, 2025
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, significantly impacting patient survival quality of life. The recent emergence immunotherapy has provided new hope for HNSCC patients, improving rates; however, only 15%–20% patients benefit, side effects are inevitable. With advancements in omics technologies growing prevalence bioinformatics research, immune microenvironment become increasingly well understood, molecular mechanisms underlying responses continue to be elucidated. In this review, we summarize commonly used techniques their applications research immunotherapy, including predicting enhancing efficacy, formulating personalized treatment plans, establishing robust preclinical models, identifying targets. Finally, explore future perspective terms sequencing samples, data integration analysis, emerging technologies, clinicopathological features, interdisciplinary approaches.
Language: Английский
Citations
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Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 31, 2025
Head and neck cancer (HNC) is an aggressive malignancy with significant effects on the innervation. Not only it at top of spectrum a dismal prognosis, but also imposes considerable stress patients society owing to frequent neurological symptoms. With progress in neuroscience, interactions between HNC nervous system, as well underlying mechanisms, have become increasingly clear. Compelling evidence suggests communication information nerve cells devastation system tumor growth. However, thorough grasp neuroscience has been severely constrained by intricacy fragmented research. This review comprehensively organizes summarizes latest research crosstalk system. It aims clarify various aspects HNC, including physiology, progression, treatment cancer. Furthermore, opportunities challenges are discussed, which offers fresh perspectives diagnosis management.
Language: Английский
Citations
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JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Importance While neoadjuvant chemotherapy for head and neck squamous cell carcinoma dates to the earliest multidisciplinary approaches, introduction of immune checkpoint inhibitors (ICIs) has renewed enthusiasm research into its use. Although therapy remained mostly investigative through single-institutional clinical trials mucosal carcinoma, new data have emerged support Observations A narrative review was conducted by American Head Neck Society address current literature, evolving research, gaps in knowledge surrounding therapy. Neoadjuvant ICIs, most notably agents targeting anti–programmed death protein 1 (anti–PD-1), are a promising approach bolstering antitumor immunity prior ablating local structures. may allow an individualized approach, biomarkers guide patient selection limited. Potential benefits include de-escalation subsequent treatment, but curable disease also carries small real risk progression compromise curative options. Measures response pathologic, clinical, radiographic, there rapidly expanding capabilities diagnostics, such as circulating tumor DNA, with emerging potential provide objective quantification burden. Further strategies adaptive therapy, treatment selection/bioselection or modification surgery, adjuvant definitive treatment. ICI summarized this review. Optimized trial designs additional needed standardize surrogate outcomes compare survival standard Conclusions Relevance can be effective option precision oncology bolstered advent anti–PD-1 immunotherapy. However, tools predicting assessing remain evaluating strategies, combinations increase efficacy, comparisons approaches.
Language: Английский
Citations
0
Trends in cancer, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0