Obesity

Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: 177(5), P. ITC65 - ITC80

Published: May 1, 2024

Obesity is a common condition and major cause of morbidity mortality. Fortunately, weight loss treatment can reduce obesity-related complications. This review summarizes the evidence-based strategies physicians employ to identify, prevent, treat obesity, including best practices diagnose counsel patients, assess address burden weight-related disease stigma, secondary causes gain, help patients set individualized realistic goals an effective plan. Effective treatments include lifestyle modification adjunctive therapies such as antiobesity medications metabolic bariatric surgery.

Language: Английский

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The current clinical approach to feeding and eating disorders aimed to increase personalization of management

World Psychiatry, Journal Year: 2025, Volume and Issue: 24(1), P. 4 - 31

Published: Jan. 15, 2025

Feeding and eating disorders (FEDs) are a heterogeneous grouping of at the mind-body interface, with typical onset from childhood into emerging adulthood. They occur along spectrum disordered compensatory weight management behaviors, low to high body weight. Psychiatric comorbidities norm. In contrast other major psychiatric disorders, first-line treatments for FEDs mainly psychological and/or nutrition-focused, medications playing minor adjunctive role. Patients, carers clinicians all have identified personalization treatment as priority. Yet, FEDs, evidence base supporting this is limited. Importantly, related behaviors can serious physical consequences may put patient's life risk. these cases, immediate safety risk considerations least period need be prioritized over efforts care. This paper systematically reviews several key domains that relevant characterization individual patient FED aimed management. These include symptom profile, clinical subtypes, severity, staging, complications consequences, antecedent concomitant conditions, social functioning quality life, neurocognition, cognition emotion, dysfunctional cognitive schemata, personality traits, family history, early environmental exposures, recent stigma, protective factors. Where possible, validated assessment measures use in practice identified. The limitations current pointed out, possible directions future research highlighted. also novel approaches providing more fine-grained sophisticated ways personalize such those utilize neurobiological markers. We additionally outline remote measurement technologies designed delineate patients' illness recovery trajectories facilitate development intervention approaches.

Language: Английский

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Autism, ADHD, and Their Traits in Adults With Bulimia Nervosa and Binge Eating Disorder: A Scoping Review

European Eating Disorders Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

ABSTRACT Objective This review maps existing literature on the prevalence of autism and ADHD in adult patients with Bulimia Nervosa (BN) Binge Eating Disorder (BED); patient stakeholder perspectives this comorbidity; clinical differences population; potential treatment adaptations or adjunct therapies. is aim to inform future research priorities improve practice. Method As pre‐registered, following PRISMA guidelines, six databases (Embase, MEDLINE via Ovid, PsycINFO, Web Science, CENTRAL, Scopus) were searched for studies regarding and/or (diagnosed, probable, traits) BN BED. Screening data extraction conducted twice independently each record. Results Twenty‐nine included, 25,416 participants, mostly women (69.3%). Thirteen suggested are more common BED than non‐ED populations. One study explored expert BED, while 15 considered options, mainly medications. Conclusion highlights a need experiences, differences, non‐medical options Autistic/ADHD Findings suggest these conditions commonly co‐occur but remain under‐explored terms patient‐centred interventions outcomes.

Language: Английский

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Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Biomedicines, Journal Year: 2022, Volume and Issue: 10(11), P. 2754 - 2754

Published: Oct. 29, 2022

Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities, including hypertension, dyslipidaemia, insulin resistance atherosclerosis. Strong evidence suggests that OSA an altered lipid profile elevated levels of triglyceride-rich lipoproteins decreased high-density lipoprotein (HDL). Intermittent hypoxia; fragmentation; consequential surges in the sympathetic activity, enhanced oxidative stress systemic inflammation are postulated mechanisms leading to alterations OSA. Although exact OSA-associated dyslipidaemia have not been fully elucidated, three main points found be impaired: activated lipolysis adipose tissue, clearance from circulation accelerated de novo synthesis. This further complicated by oxidisation atherogenic lipoproteins, tissue dysfunction, hormonal changes, reduced function HDL particles In this comprehensive review, we summarise critically evaluate current about possible involved dyslipidaemia.

Language: Английский

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Successful treatment of binge eating disorder with the GLP-1 agonist semaglutide: A retrospective cohort study

Obesity Pillars, Journal Year: 2023, Volume and Issue: 7, P. 100080 - 100080

Published: July 20, 2023

Binge eating disorder (BED) is the most common disorder, and yet only one pharmacotherapy (lisdexamfetamine), which has known abuse-potential, FDA-approved. Topiramate also commonly prescribed off-label for binge but many contraindications. In contrast, glucagon-like peptide-1 (GLP1) analog semaglutide profound effects on central satiety signaling leading to reduced food intake, been approved treatment of obesity based its efficacy safety profile. Semaglutide would thus seem be a potential candidate BED.This open-label study examined Eating Scale (BES) scores in individuals with BED. Patients were divided into three groups: those semaglutide, either lisdexamphetamine or topiramate, combination topiramate.Patients receiving exhibited greater reductions BES compared other groups. Combined both anti-obesity medications did not result semaglutide-only group. Findings similar patients moderate/severe BED, as well full sample.The therapeutic warrant further investigation.

Language: Английский

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Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(4), P. 361 - 379

Published: March 14, 2024

Eating disorders (EDs) and obesity are complex health conditions sharing various risk maintenance factors, intensified in cases of comorbidity. This review explores the similarities connections between these conditions, examining different facets from a multidisciplinary perspective, among them comorbidities, metabolic psychological neurobiological aspects, management therapy implications. We aim to investigate common characteristics complexities weight EDs explore their interrelationships individuals who experience both. The rising prevalence people with necessitates integrated approaches study this comorbidity identify analyze both distinct features conditions. may offer new opportunities for simultaneous prevention approaches, as well future lines research.

Language: Английский

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Effects of Mindful Eating in Patients with Obesity and Binge Eating Disorder

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 884 - 884

Published: March 19, 2024

Introduction: Binge eating disorder (BED) is a psychiatric illness related to high frequency of episodes binge eating, loss control, body image dissatisfaction, and suffering caused by overeating. It estimated that 30% patients with BED are affected obesity. “Mindful eating” (ME) promising new technique can improve self-control good food choices, helping increase awareness about the triggers intuitive training. Objectives: To analyze impact ME on quality life, habits, anthropometric data [weight, Body Mass Index (BMI), waist circumference] in obesity BED. Method: This quantitative, prospective, longitudinal, experimental study recruited 82 diagnosed The intervention was divided into eight individual weekly meetings, guided sessions, nutritional educational dynamics, cooking workshops, sensory analyses, applications questionnaires [Body Shape Questionnaire (BSQ); Eating Scale (BES); Quality Life (WHOQOL-BREF)]. There no dietary prescription for calories, carbohydrates, proteins, fats, fiber. Patients were only encouraged consume fewer ultra-processed foods more natural minimally processed foods. meetings occurred from October November 2023. Statistical analysis: carry out inferential statistics, Shapiro–Wilk test used verify normality variable distribution. All variables identified as non-normal distribution compared between first eighth week using two-tailed Wilcoxon test. Non-Gaussian represented median ± interquartile range (IQR). Additionally, α < 0.05 p adopted. Results: Significant reductions found weight, BMI, circumference, BSQ scale score, BES total energy value (all 0.0001). In contrast, there significant WHOQOL-BREF score daily water intake (p Conclusions: improved data, life participants short-term. However, an extension project will be necessary long-term.

Language: Английский

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Eating disorders in men—an underestimated problem, an unseen need

Deutsches Ärzteblatt international, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Eating disorders are seen mainly as a problem affecting women, not just by the public at large, but also in specialized circles. Although it is true that more women than men suffer from all types of eating disorder, pertinent reviews have clearly shown they do indeed occur men, and available evidence on matter limited. The stigmatization with makes harder for these relevant professionals, to recognize symptoms seek or provide help.

Language: Английский

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Effectiveness of a Web-Based Cognitive Behavioral Self-Help Intervention for Binge Eating Disorder

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(5), P. e2411127 - e2411127

Published: May 16, 2024

Binge eating disorder (BED) is one of the most frequent pathologies and imposes substantial emotional physical distress, yet insufficient health care resources limit access to specialized treatment. Web-based self-help interventions emerge as a promising solution, offering more accessible care.

Language: Английский

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Body image differs in weight-based stereotypes between patients with bulimia nervosa and binge eating disorder: findings from the BodyTalk project

Journal of Eating Disorders, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 17, 2025

Abstract Bulimia Nervosa (BN) and Binge Eating Disorder (BED) have considerable symptom overlap, prior studies observed similiarities in respect to patient’s body image. However, weight-based stereotypes so far not been considered together with other facets of This study investigated image, size estimation accuracy a German-Italian sample 22 patients BN, BED 44 weight-matched controls who had no eating disorder. Patients BN reported significantly more negative image than were differently accurate estimating their the controls. showed stronger compared controls, suggesting that these hold apply lower weight excessively. Observations from this suggest clinical treatment disturbance should address differentiated way.

Language: Английский

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