bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Candida
albicans
is
a
commensal
yeast
that
common
component
of
the
gastrointestinal
(GI)
microbiome
humans.
C.
has
been
shown
to
bloom
in
GI
tract
individuals
with
alcohol
use
disorder
(AUD)
and
can
promote
increase
severity
alcoholic
liver
disease
(ALD).
However,
effects
blooms
on
host
context
AUD
or
AUD-related
phenotypes,
such
as
ethanol
preference,
have
unstudied.
In
this
work,
we
report
reduction
consumption
preference
mice
colonized
.
albicans-
exhibited
elevated
levels
serum
PGE
2
reduced
was
reversed
by
injection
antagonists
receptors.
Further,
derivative
decreased
their
preference.
These
results
show
acting
its
receptors
EP1
EP2
drives
mice.
We
also
showed
altered
transcription
dopamine
dorsal
striatum
more
rapid
acquisition
conditioned
taste
aversion,
suggesting
alterations
reinforcement
aversion
learning.
Finally,
-colonized
were
susceptible
ethanol-induced
motor
coordination
impairment
showing
significant
behavioral
ethanol.
This
study
identifies
member
fungal
alters
demonstrates
role
for
signaling
these
phenotypes.
found
gut
most
individuals.
contribute
disease.
Outside
this,
impact
intestinal
fungi
alcohol-use
had
As
complex
characterized
high
relapse
rates,
there
are
only
3
FDA-approved
therapies
maintenance
abstinence,
it
important
novel
contributors
find
new
therapeutic
targets.
Here
an
fungus,
,
alter
mammalian
through
immune
modulator,
prostaglandin
E
The
highlight
phenotypes
further
implicate
gut-brain
axis
AUD.
Future
studies
could
lead
avenues
treatment
Nature Mental Health,
Journal Year:
2023,
Volume and Issue:
1(10), P. 736 - 750
Published: Sept. 11, 2023
Abstract
Lifestyle
factors
have
been
acknowledged
to
be
modifiable
targets
that
can
used
counter
the
increasing
prevalence
of
depression.
This
study
aims
investigate
combining
an
extensive
range
lifestyle
factors,
including
alcohol
consumption,
diet,
physical
activity,
sleep,
smoking,
sedentary
behavior
and
social
connection,
contribute
depression,
examine
underlying
neurobiological
mechanisms.
Over
nine
years
follow-up,
a
multivariate
Cox
model
was
utilized
on
287,282
participants
from
UK
Biobank
demonstrate
protective
roles
seven
combined
score
Combining
genetic
risk
category
in
197,344
participants,
we
found
healthy
decreased
depression
across
population
with
varied
risk.
Mendelian
randomization
confirmed
causal
relationship
between
A
broad
brain
regions
peripheral
biomarkers
were
related
lifestyle,
pallidum,
precentral
cortex,
triglycerides
C-reactive
protein.
Structural
equation
modeling
18,244
revealed
mechanisms
involving
structure,
immunometabolic
function,
genetics
Together,
our
findings
suggest
adherence
could
aid
prevention
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 25, 2024
Depression,
projected
to
be
the
predominant
contributor
global
disease
burden,
is
a
complex
condition
with
diverse
symptoms
including
mood
disturbances
and
cognitive
impairments.
Traditional
treatments
such
as
medication
psychotherapy
often
fall
short,
prompting
pursuit
of
alternative
interventions.
Recent
research
has
highlighted
significant
role
gut
microbiota
in
mental
health,
influencing
emotional
neural
regulation.
Fecal
transplantation
(FMT),
infusion
fecal
matter
from
healthy
donor
into
patient,
emerges
promising
strategy
ameliorate
depressive
by
restoring
microbial
balance.
The
microbial-gut-brain
(MGB)
axis
represents
critical
pathway
through
which
potentially
rectify
dysbiosis
modulate
neuropsychiatric
outcomes.
Preclinical
studies
reveal
that
FMT
can
enhance
neurochemicals
reduce
inflammatory
markers,
thereby
alleviating
behaviors.
Moreover,
shown
promise
clinical
settings,
improving
gastrointestinal
overall
quality
life
patients
depression.
review
highlights
gut-brain
depression
need
for
further
validate
long-term
safety
efficacy
FMT,
identify
specific
therapeutic
strains,
develop
targeted
modulation
strategies.
Advancing
our
understanding
could
revolutionize
treatment,
shifting
paradigm
toward
microbiome-targeting
therapies.
Drug and Alcohol Dependence,
Journal Year:
2023,
Volume and Issue:
253, P. 111019 - 111019
Published: Nov. 4, 2023
'Alcohol
use
disorder'
(AUD)
is
used
by
several
contemporary
conceptualizations
to
identify,
treat
and
prevent
problems
associated
with
alcohol
use.
Such
encompass
diagnostic
classifications
broader
frameworks
for
policy
practice.
However,
current
AUD
concepts
are
subject
multiple
tensions
limitations
in
capturing
responding
the
complex
heterogeneous
nature
of
problems.
Further,
public
understandings
heavily
divergent
from
professional
remain
embedded
within
an
'alcoholism'
master
narrative
which
disease
model
stereotypes
come
costs
prevention
'recovery'.
The
persistence
a
problematic
paradigm
reflects
coalescing
forces
including
cognitive
appeal
reductionism,
motives
stigmatize
'other',
over-emphasis
on
as
individually
located
biomedical
problem.
Public
misperceptions
matter
individual,
individual's
essence,
misconceived
notions
responsibility
control
have
been
bolstered
industry
interests
ascension
neuroscience
genetics,
turn
diverting
attention
importance
environmental
commercial
determinants
health
effectiveness
under-utilized
policies.
We
call
stakeholders
support
efforts
prioritize
first
approach
advancing
research,
treatment
order
make
significant
advances
treatment.
offer
recommendations
assist
shifting
understanding
scientific
responses.
