Baseline HBsAg quantitative and CD4 T cell counts are associated with HBsAg loss in people living with HIV/HBV coinfection after combined antiretroviral therapy DOI Creative Commons

Muye Xia,

Yuhang Zhao, Tao Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 19, 2025

Achieving Hepatitis B surface antigen (HBsAg) loss is a significant goal for chronic hepatitis patients. This study aims to evaluate HBsAg in individuals with HIV/HBV coinfection and explore the association of clinical variables this outcome. We enrolled 138 coinfected 480 HBV mono-infected who initiated antiviral treatment. employed Kaplan-Meier analysis compare rate between those mono-infection. In cohort, we used Cox proportional hazards models assess various factors incidence loss. The cumulative was higher among HBV/HIV (13 patients, 11.5% at year 3) compared (1 patient, 0.6%) after therapy. multivariable revealed that lower baseline level (HR 0.53; 95% CI 0.38-0.74, p<0.001) CD4 T cell counts < 180 cells/uL 0.32; 0.10-0.96, p=0.042) were associated an increased indicator Additionally, receiver-operating characteristic curve indicated area under 0.771 levels 0.758 1 predicting After antiretroviral therapy, adults achieve rates Baseline quantitative are combined therapy may inform treatment decisions.

Language: Английский

The Predictive Value of Lactate Dehydrogenase for Viral Suppression in Newly Diagnosed People Living With HIV on Antiretroviral Therapy: A Retrospective Cohort Study DOI Creative Commons
Yong Jun Jin, Yan Wang, Ting Xia

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 601 - 611

Published: Jan. 1, 2025

Rapid initiation of antiretroviral therapy (ART) in people living with HIV (PLWH) is crucial for achieving viral suppression and improving clinical outcomes. Serum lactate dehydrogenase (LDH) levels serve as a readily accessible rapid biomarker, has significant predictive potential various diseases. This study aims to evaluate the value LDH context ART initiation. were measured 393 newly diagnosed PLWH who received subsequently followed up. The stratified based on tertile endpoints. Kaplan-Meier analysis was conducted generate survival curves, Cox regression utilized confirm independent prognostic factors suppression. overall rate 94.1%. Compared low tertile, middle high tertiles exhibited longer times first (38 vs 84 88 days, respectively, P < 0.001). revealed that showed worst prognosis (Log rank test, P<0.001). Multivariate identified predictor (HR = 0.714, 95% CI 0.553-0.922, 0.010 tertile; HR 0.575, 0.443-0.747, 0.001 tertile). function indicator predicting timing ART. A comprehensive evaluation beneficial establishing risk stratification

Language: Английский

Citations

0
Mathematical Overview of Biochemical and Physical Interactions Considering Reverse Transcriptase and Integrase Enzymes to Explore HIV Progression: A Control Theoretic Approach DOI
Tushar Ghosh, Elissa J. Schwartz, Salil Ghosh

et al.

Springer proceedings in mathematics & statistics, Journal Year: 2025, Volume and Issue: unknown, P. 53 - 68

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring 4-quinolone-3-carboxamide derivatives: A versatile framework for emerging biological applications DOI
Joana Andrade, Thiago Mota do Vale,

R. Gomes

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108240 - 108240

Published: Feb. 3, 2025

Language: Английский

Citations

0
Electroanalytical determination of darunavir as antiretroviral drug by a sensor containing synthesized reduced graphene oxide DOI

Maryam Lak,

Seyed Karim Hassaninejad–Darzi

Journal of Solid State Electrochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Baseline HBsAg quantitative and CD4 T cell counts are associated with HBsAg loss in people living with HIV/HBV coinfection after combined antiretroviral therapy DOI Creative Commons

Muye Xia,

Yuhang Zhao, Tao Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 19, 2025

Achieving Hepatitis B surface antigen (HBsAg) loss is a significant goal for chronic hepatitis patients. This study aims to evaluate HBsAg in individuals with HIV/HBV coinfection and explore the association of clinical variables this outcome. We enrolled 138 coinfected 480 HBV mono-infected who initiated antiviral treatment. employed Kaplan-Meier analysis compare rate between those mono-infection. In cohort, we used Cox proportional hazards models assess various factors incidence loss. The cumulative was higher among HBV/HIV (13 patients, 11.5% at year 3) compared (1 patient, 0.6%) after therapy. multivariable revealed that lower baseline level (HR 0.53; 95% CI 0.38-0.74, p<0.001) CD4 T cell counts < 180 cells/uL 0.32; 0.10-0.96, p=0.042) were associated an increased indicator Additionally, receiver-operating characteristic curve indicated area under 0.771 levels 0.758 1 predicting After antiretroviral therapy, adults achieve rates Baseline quantitative are combined therapy may inform treatment decisions.

Language: Английский

Citations

0