İntramusküler Diklofenak Sodyum Enjeksiyon Sonrası Toksik Epidermal Nekroliz ve Çoklu Organ Yetmezliği: Olgu Sunumu DOI Open Access

Nalan Şanlı,

Nigar Bircan Ocak,

Kerem Erkalp

et al.

Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi, Journal Year: 2013, Volume and Issue: 11(2), P. 83 - 85

Published: Aug. 5, 2013

ÖZET İntramusküler enjeksiyon, çok sık uygulanan temel bir tıbbi girişimdir.İlk akla gelen komplikasyonu siyatik sinir hasarı olsa da yumuşak dokuyu ilgilendiren sorunlarla

Delayed Skin Testing for Systemic Medications: Helpful or Not? DOI Creative Commons
A. Barbaud, Margarida Gonçalo, Maja Mockenhaupt

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(9), P. 2268 - 2277

Published: July 6, 2024

Cutaneous adverse drug reactions collectively are delayed such as morbilliform eruption and severe cutaneous (SCARs). Morbilliform may wane over time, be the result of viral interactions, amenable to slow reintroduction or rechallenge, whereas SCARs HLA class I restricted, T-cell-mediated that demonstrate durable immunity warrant lifelong avoidance. reaction with eosinophilia systemic symptoms, Stevens-Johnson syndrome toxic epidermal necrolysis, acute generalized exanthematous pustulosis, bullous fixed often occur in setting multiple drugs dosed together. Collectively, they lead significant morbidity, mortality, safety concerns could severely limit future treatment options. Currently, no single combination diagnostic tests for ex vivo vitro testing, (skin) other adjunctive typing have 100% negative predictive value. In this "Controversies Allergy Review" article, we review current literature on skin testing (patch prick/intradermal test) critically assess evidence base its utility across different clinical phenotypes hypersensitivity reactions.

Language: Английский

Citations

4
Palliative Care for Severe Cutaneous Adverse Reactions: Gaps, Challenges, and the Way Forward DOI
Jonathan Bayuo

Journal of Pain and Symptom Management, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis DOI Creative Commons
Benjamin Y. Klein, J. Michelle Kahlenberg, Jóhann E. Guðjónsson

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 2, 2025

Language: Английский

Citations

0
Extracellular Granzyme B mediates degradation of Collagen XVII in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis DOI Creative Commons
Michael D. Lane, Alexandre Aubert,

Anna Prudova

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Characterization of Demographics, Drug Latency, and Mortality of Severe Cutaneous Adverse Reactions in an FDA Pharmacovigilance Database DOI
Eric Mukherjee, David S. Park, Michelle D Martin-Pozo

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract Background Severe cutaneous adverse reactions (SCARs) are rare, life-threatening conditions associated with drug exposure. These differ globally in causative agents, demographics, and latency (time between administration reaction). We provide a comprehensive survey of SCAR pharmacovigilance database maintained by the FDA. Methods After sanitization, FDA Adverse Events Reporting System (FAERS) from January 2004 to December 2003 was queried for cases. Disproportionality analyses measured associations drugs SCAR. Random forests were used determine influence covariates on mortality. Findings A total 56,683 cases reported, comprising 0.33% reports. 49.4% female (28008). The median age patients 53 (interquartile range [IQR] 32-68), significant differences phenotypes. There has been an increase reporting over time, particularly biologics immune checkpoint inhibitors (ICI). Over 200 had positive disproportionality signals. Several co-reported two SJS-TEN, DRESS, and/or AGEP, indicating possibility intermediate TTE analysis showed is most influential variable latency, followed number concomitant drugs. Mortality varied increased Interpretation This largest retrospective study date shows variety phenotypes, demographic variables, latencies, mortality this population. demonstrates power using databases rare reactions. Continued mining these databases, electronic health records, prospective data can expand upon results, better characterize variations, improve recognition care Funding National Institutes Health, Vanderbilt University Medical Center.

Language: Английский

Citations

0
Pharmacogenomic variants in the Pumi population from Yunnan, China DOI
Xiao Yang,

Yujing Cheng,

Qi Li

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149421 - 149421

Published: March 1, 2025

Language: Английский

Citations

0
TOP10‐SCAR: A Global Pharmacovigilance Study on Medications Most Frequently Related to Severe Cutaneous Adverse Reactions DOI
Jaehyeong Cho,

Hyesu Jo,

Jaeyu Park

et al.

Allergy, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Immune-related toxic epidermal necrolysis affecting trachea mucosal epithelium: a case report and literature review DOI Creative Commons
Mingbo Zhang, Yang Fu,

Yuxiao Song

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background Monoclonal antibodies against programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) have emerged as critical tools in cancer treatment. However, concerns regarding their potential cutaneous and mucosal toxicity, along with severe complications, drawn clinical attention. Further research is warranted to investigate the adverse reactions treatment strategies associated PD-1 monoclonal antibodies. Methods We present a detailed case report of laryngeal patient who developed toxic epidermal necrolysis (TEN) after antibody. analyzed etiology, diagnosis, approaches by integrating manifestations, pathological examinations, literature research. Results After antibody therapy, exhibited systemic rash, bullae, detachment, which subsequently involved tracheal bronchial mucosa, resulting dyspnea. The recovered treatments steroids, macrolides, immunoglobulins, etanercept, repeated removal scabs via bronchoscopy. Literature reviewing suggests association between pathogenesis Steven Johnson’s Syndrome (SJS) Toxic (TEN), possibly due immune dysregulation. Treatment consists immediate discontinuation suspicious drugs, essential supportive corticosteroid administration, addition immunosuppressants and/or immunoglobulins needed. Conclusion mucocutaneous toxicity induced not limited surface skin but also deep layers, potentially leading life-threatening complications. Therefore, when using antibodies, clinicians should closely monitor events apply appropriate soon possible prevent

Language: Английский

Citations

1
The systemic treatments for drug reaction with eosinophilia and systemic symptoms (DRESS) beyond corticosteroids DOI Creative Commons

Sifan Wang,

Y. James Kang,

Chun‐Xia He

et al.

World Allergy Organization Journal, Journal Year: 2024, Volume and Issue: 17(8), P. 100935 - 100935

Published: July 20, 2024

Language: Английский

Citations

0
Ocular involvement in Steven-Johnson syndrome/toxic epidermal necrolysis: recent insights into pathophysiology, biomarkers, and therapeutic strategies DOI
Punyanuch Pisitpayat,

Sarayut Nijvipakul,

Passara Jongkhajornpong

et al.

Current Opinion in Ophthalmology, Journal Year: 2024, Volume and Issue: 35(6), P. 499 - 506

Published: Aug. 12, 2024

To review the pathophysiology, recent biomarkers related to ocular aspects of Steven-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and highlight notable evidence published in years.

Language: Английский

Citations

0