Aldose Reductase: A Promising Therapeutic Target for High-Altitude Pulmonary Edema

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 341 - 341

Published: Jan. 2, 2025

The Qinghai–Tibet Plateau, famously known as the “Roof of World”, has witnessed a surge in individuals traveling or working there. However, considerable percentage these may suffer from acute mountain sickness (AMS), with high-altitude pulmonary edema (HAPE) being severe and potentially life-threatening manifestation. HAPE disrupts balance intrapulmonary tissue fluid, resulting lung function impairment. Current therapeutic interventions for have limitations are accompanied by significant side effects. Aldose reductase (AR), crucial enzyme polyol metabolic pathway, been implicated various diseases. In this study, we sought to explore role AR HAPE. Utilizing both vivo vitro models, investigated impact on hypoxia-induced edema, vascular pressure, inflammatory factors, oxidative stress. Our findings revealed that knockdown mitigated decreased expression pressure enhanced related These results indicate serve potential target HAPE, offering plausible pathological basis novel drug targets prevention treatment condition.

Language: Английский

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Improved oxygen saturation and acclimatization with bacteriotherapy at high altitude

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112053 - 112053

Published: Feb. 17, 2025

Language: Английский

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Cardiorespiratory fitness and effects of ubiquinol during high-altitude acclimatization and deacclimatization: the SCARF trial

iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 112112 - 112112

Published: Feb. 27, 2025

Language: Английский

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Understanding the Mechanistic and Therapeutic Perspectives on Cytokines and Chemokines in Acute High-Altitude Illness Syndromes

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101249 - 101249

Published: Feb. 1, 2025

Language: Английский

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Systemic inflammatory response syndrome and multiple organ dysfunction syndrome caused by acute mountain sickness: a case report and literature review

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 7, 2025

Acute mountain sickness (AMS) is a common condition following rapid exposure to high altitude, though severe complications such as acute gastrointestinal bleeding, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction (MODS) are rare. Herein, we report case of SIRS MODS in young traveler who visited Lhasa, Tibet (elevation 3,650 m). Three days after arrival, the patient developed headache, abdominal pain, significant hematemesis, persistent hypotension. Gastroscopy revealed diffuse bleeding gastric mucosa. Laboratory tests indicated multi-organ involving lungs, liver, kidneys. The responded well conservative treatment continuous oxygen supplementation. This represents one first reported instances mucosal injury induced by AMS, underscoring medical risks associated with high-altitude environments.

Language: Английский

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Oxygen metabolism abnormalities and high-altitude cerebral edema

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Hypobaric hypoxia is widely recognized as a prominent risk factor for high-altitude cerebral edema (HACE), which contributes to the exacerbation of multiple pathological mechanisms, including oxidative stress, mitochondrial dysfunction, disruption blood−;brain barrier integrity, neuroinflammation, and neuronal apoptosis. Among these abnormalities in oxygen metabolism, hypoxia, play pivotal roles pathophysiology HACE. In this review, our objective enhance comprehension underlying molecular mechanisms implicated HACE by investigating potential involvement metabolism. Addressing aberrations metabolism holds promise providing innovative therapeutic strategies managing

Language: Английский

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Ambulatory Blood Pressure in Tourists at Low Versus High Altitude: Colorado High Altitude Monitoring Pressure Study

Wilderness and Environmental Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

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Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

ABSTRACT This study investigated the longitudinal effects of acute (7-day) and prolonged (3-month) high-altitude exposure on gut microbiota in healthy adult males, addressing limited data available human populations. A cohort 406 males was followed, fecal samples were collected at three time points: baseline 800 m (406 samples), 7 days after ascending to 4,500 2 weeks post-return following 3 months high altitude (186 samples). High-throughput 16S ribosomal DNA sequencing employed analyze composition diversity. Results revealed significant changes alpha- beta-diversity, with inducing more pronounced compared exposure. Specifically, increased opportunistic pathogens ( Ruminococcus Oscillibacter ) but decreased beneficial short-chain fatty acid producers Faecalibacterium Bifidobacterium ). Notably, these persisted even returning low altitude, indicating long-term remodeling. Functional analyses substantial metabolic pathways, suggesting microbiota-driven adaptations energy utilization under hypoxic conditions. In summary, caused dramatic microbiota, while led structural functional reshaping. These findings enhance our understanding how environments reshape microbiota. IMPORTANCE is first investigate impact adaptation a large-scale cohort. It seeks Acute significantly affected both α-diversity β-diversity causing than adaptation, temporary disruptions microbial communities. Notable shifts abundance observed, including levels genera linked stress (e.g., Gemmiger , Parabacteroides bacteria Roseburia ), possible adverse health effects. analysis indicated metabolism-related pathways post-exposure, supporting idea that involve adjustments for management. physiology, illustrating role health.

Language: Английский

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Unraveling the pathogenesis and prevention strategies of acute high-altitude illness through gut microecology

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 22, 2025

High-altitude environments, characterized by hypobaric and hypoxic conditions, induce acute hypoxia, resulting in decreased blood oxygen saturation. This stress perturbs gut microecological homeostasis, significantly contributing to the pathogenesis of mountain sickness. Consequently, elucidating mechanisms which high altitude affects homeostasis is crucial for developing effective interventions.

Language: Английский

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Emergency Care for High-Altitude Trekking and Climbing

High Altitude Medicine & Biology, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

High altitude regions are characterized by harsh conditions (environmental, rough terrain, natural hazards, and limited hygiene health care), which all may contribute to the risk of accidents/emergencies when trekking or climbing. Exposure hypoxia, cold, wind, solar radiation typical features high environment. Emergencies in these remote areas place demands on diagnostic treatment skills doctors first-aiders. The aim this review is give insights providing best possible care for victims emergencies at altitude.

Language: Английский

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