Clinical and Translational Discovery, Journal Year: 2025, Volume and Issue: 5(3)
Published: May 19, 2025
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 2, 2025
Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as hallmark cancer. It exerts context-dependent dual role in cancer initiation and progression, functioning tumor suppressor promoter. The complexity senescence arises from its mechanistic diversity, potential reversibility, heterogeneity. A key mediator these effects the senescence-associated secretory phenotype (SASP), repertoire bioactive molecules that influence microenvironment (TME) remodeling, modulate behavior, contribute to therapeutic resistance. Given intricate biology, presents both challenges opportunities for intervention. Strategies targeting pathways, including senescence-inducing therapies senolytic approaches, offer promising avenues treatment. This review provides comprehensive analysis regulatory mechanisms governing cellular tumors. We also discuss emerging strategies highlighting novel opportunities. deeper understanding processes essential developing precision improving clinical outcomes.
Language: Английский
Citations
3
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Relationships between cellular senescence and gastrointestinal cancers have gained prominence in recent years. The currently accepted theory suggests that cancer occurrence exhibit "double-edged sword" effects. Cellular is related to via four "meta-hallmarks" i.e., genomic instability, epigenetic alterations, chronic inflammation, dysbiosis, along with two "antagonistic hallmarks" telomere attrition stem cell exhaustion. These relationships are characterized by both agonistic antagonistic elements, but the existence of an intricate dynamic balance remains unknown. Non-coding RNAs (ncRNAs) vital roles post-transcriptional regulation, how they participate be fully investigated. In this article, we systematically review ncRNAs (including microRNAs (miRNAs), long (lncRNAs), circularRNAs (circRNAs)) interactions cancers. Our aim elucidate a triangular relationship "ncRNAs-senescence-gastrointestinal cancers" which considered these three elements as equal important standing. We keen identify prognostic or therapeutic targets for from, aging-related ncRNAs, discover novel strategies treat manage elderly. seek clarify complex where "senescence-gastrointestinal interactions.
Language: Английский
Citations
0
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 111, P. 1 - 15
Published: Feb. 9, 2025
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 752, P. 151482 - 151482
Published: Feb. 11, 2025
Language: Английский
Citations
0
Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112056 - 112056
Published: April 1, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 545 - 545
Published: April 8, 2025
Aging is a predominant risk factor for cardiovascular diseases. There evidence demonstrating that senescent cells not only play significant role in organism aging but also contribute to the pathogenesis of diseases younger ages. Encouraged by recent findings elimination pharmacogenetic tools could slow down and even reverse animal models, senolytic drugs have been developed, translation results from basic research clinical settings has initiated. Because numerous studies literature show beneficial therapeutic effects targeting cardiomyopathies associated with ischemia/reperfusion atherosclerotic vascular disease, are considered next generation therapies disorders. However, reported controversial or detrimental caused approaches, including worsening cardiac dysfunction, instability plaques, an increase mortality which challenges therapy into practice. This brief review article will focus on (1) analyzing discussing approaches (2) future directions questions essential understand controversies translate preclinical
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 619 - 619
Published: April 21, 2025
A significant increase in life expectancy worldwide has resulted a growing aging population, accompanied by rise aging-related diseases that pose substantial societal, economic, and medical challenges. This trend prompted extensive efforts within many scientific communities to develop enhance therapies aimed at delaying processes, mitigating functional decline, addressing aging-associated extend health span. Research biology focused on unraveling various biochemical genetic pathways contributing changes, including genomic instability, telomere shortening, cellular senescence. The advent of induced pluripotent stem cells (iPSCs), derived through reprogramming human somatic cells, revolutionized disease modeling understanding humans the limitations conventional animal models primary cells. iPSCs offer advantages over other such as embryonic they can be obtained without need for embryo destruction are not restricted availability healthy donors or patients. These attributes position iPSC technology promising avenue deciphering mechanisms underlie associated diseases, well studying drug effects. Moreover, exhibit remarkable versatility differentiating into diverse cell types, making them tool personalized regenerative replacing aged damaged with healthy, equivalents. review explores breadth research iPSC-based their potential applications spectrum conditions.
Language: Английский
Citations
0
Cell chemical biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 24, 2025
Current antiretroviral therapy (ART) for HIV infection reduces plasma viral loads to undetectable levels and has increased the life expectancy of people with (PWH). However, this lifespan is accompanied by signs accelerated aging a higher prevalence age-related comorbidities. Tat (Trans-Activator Transcription) key protein replication pathogenesis. encoded 2 exons, full-length ranging from 86 101 aa (Tat101). Introducing stop codon in position 73 generates 1 exon, synthetic 72aa (Tat72). Intracellular, activates NF-κB pro-inflammatory pathway increases antiapoptotic signals ROS generation. These effects may initiate cellular senescence program, characterized cell cycle arrest, altered metabolism, senescence-associated secretory phenotype (SASP) mediator release precise role HIV-Tat inducing program CD4+ T-cells currently unknown. Jurkat Tetoff lines stably transfected Tat72, Tat101, or an empty vector were used. Flow cytometry RT-qPCR used address biomarkers, 105 mediators assessed supernatants antibody-based membrane array. Key results obtained Jurkat-Tat cells addressed primary, resting transient electroporation HIV-Tat-FLAG plasmid DNA. In model, expression Tat101 biomarkers BCL-2, CD87, p21, sCD30, PDGF-AA, sCD31, among other factors. upregulated CD30 CD31 co-expression surface, distinguishing these Tat72 Jurkats. The percentage p21+, p16+, γ-H2AX+ Tat-expressing T-cells, detected as FLAG+ population compared their FLAG- (Tat negative) counterparts. Increased sCD31 sCD26 also electroporated T-cell supernatants. several SASP/Aging Intracellular contributing premature observed PWH.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Liver fibrosis is a major global health problem without effective therapies, and targeted elimination of senescent cells beneficial for hepatic function organism survival. We report new trilocked photodynamic senolytic inducer (PDSI) strategy liver resolution using type-I agent immunogenic clearance cells. demonstrate that this PDSI not only facilitates efficient production superoxide anions (O2•-) in lysosomes therapy, but also permits NIR fluorescence photoacoustic (NIRF/PA) imaging Mechanistic investigation reveals the elicited cell predominantly via necroptosis pathway. Moreover, with liver-targeting moiety enables high-contrast NIRF/PA vivo. This exhibits remarkable ablation cells, enhancing dendritic maturation cytotoxic T recruitment fibrosis. Our study highlights potential type I boosting immunity treatment.
Language: Английский
Citations
0