Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1405 - 1405

Published: April 22, 2021

The importance of metabolic health is a major societal concern due to the increasing prevalence diseases such as obesity, diabetes, and various cardiovascular diseases. circadian clock clearly implicated in development these Indeed, it regulates physiological processes by hormone modulation, thus helping body perform them at ideal time day. Since industrial revolution, actions rhythms everyday life have been modified are characterized changes sleep pattern, work schedules, eating habits. These modifications turn lead night shift, social jetlag, late-night eating, meal skipping, group customs that causes rhythm disruption leads an increase risks. Intermittent fasting, especially time-restricted proposes solution: restraining feeding window from 6 10 h per day match with clock. This approach seems improve markers could be therapeutic solution fight against review summarizes matching habits for assesses advantages limits application fasting objective treating preventing

Language: Английский

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Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

Cell, Journal Year: 2021, Volume and Issue: 184(3), P. 709 - 722.e13

Published: Jan. 21, 2021

Language: Английский

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Time-restricted eating and circadian rhythms: the biological clock is ticking

Critical Reviews in Food Science and Nutrition, Journal Year: 2020, Volume and Issue: 61(17), P. 2863 - 2875

Published: July 14, 2020

Meal timing may be a critical modulator of health outcomes due to complex interactions between circadian biology, nutrition and human metabolism. As such, approaches that aim align food consumption with endogenous rhythms are emerging in recent years. Time-restricted eating (TRE) consists limiting daily nutrient period 4 12 hours order extend the time spent fasted state. TRE can induce positive effects on individuals overweight obesity, including sustained weight loss, improvement sleep patterns, reduction blood pressure oxidative stress markers increased insulin sensitivity. However, it is not fully clear whether reduced energy intake, body or truncation window. In addition, null some populations parameters cardiometabolic have been documented. Some evidence indicates greater promotion via achieved if intake occurs earlier day. Despite promise this dietary strategy, performing at different times day health, as well safety efficacy approach impairments, need evaluated additional controlled long-term studies.

Language: Английский

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The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

Physiological Reports, Journal Year: 2021, Volume and Issue: 9(1)

Published: Jan. 1, 2021

Chronic sleep loss is a potent catabolic stressor, increasing the risk of metabolic dysfunction and muscle mass function. To provide mechanistic insight into these clinical outcomes, we sought to determine if acute deprivation blunts skeletal protein synthesis promotes environment. Healthy young adults (N = 13; seven male, six female) were subjected one night total (DEP) normal (CON) in randomized cross-over design. Anabolic hormonal profiles assessed across following day. Postprandial fractional rate (FSR) was between 13:00 15:00 gene markers degradation at 13:00. Acute reduced by 18% (CON: 0.072 ± 0.015% vs. DEP: 0.059 0.014%·h-1 , p .040). In addition, increased plasma cortisol 21% (p .030) decreased testosterone 24% .029). No difference found degradation. A single sufficient induce anabolic resistance procatabolic These changes may represent precursors driving body composition associated with chronic deprivation.

Language: Английский

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The Microbiota and the Gut–Brain Axis in Controlling Food Intake and Energy Homeostasis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 5830 - 5830

Published: May 29, 2021

Obesity currently represents a major societal and health challenge worldwide. Its prevalence has reached epidemic proportions trends continue to rise, reflecting the need for more effective preventive measures. Hypothalamic circuits that control energy homeostasis in response food intake are interesting targets body-weight management, example, through interventions reinforce gut-to-brain nutrient signalling, whose malfunction contributes obesity. Gut microbiota–diet interactions might interfere sensing signalling from gut brain, where information is processed homeostasis. This microbiota–brain crosstalk mediated by metabolites, mainly short chain fatty acids, secondary bile acids or amino acids-derived metabolites subcellular bacterial components. These activate gut–endocrine and/or neural-mediated pathways pass systemic circulation then reach brain. Feeding time dietary composition main drivers of microbiota structure function. Therefore, aberrant feeding patterns unhealthy diets alter modify availability microbial ligands transmitting brain intake, thus impairing Herein, we update scientific evidence supporting source novel non-dietary biological products may beneficially regulate communication and, thus, improve metabolic health. Additionally, evaluate how modulate thereby, intraluminal these with potential effects on The review also identifies knowledge gaps advances required clinically apply microbiome-based strategies gut–brain axis function combat

Language: Английский

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