Clinical manifestations of polycystic ovary syndrome

Medicinska istrazivanja, Journal Year: 2024, Volume and Issue: 57(4), P. 93 - 102

Published: Jan. 1, 2024

Polycystic ovary syndrome, commonly abbreviated as PCOS, the most common endocrine disorder in women of reproductive age, is a multifaceted disease characterized by various hormonal imbalances and great degree variation its clinical presentation. This, coupled with etiology pathogenesis being incompletely understood, results broad spectrum that challenging to accurately diagnose manage. The primary features which PCOS manifests include hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology, though all three are not necessarily present patients. Hyperandrogenism, manifesting hirsutism, acne, male-pattern alopecia, significantly affects both physical psychological wellbeing these Ovulatory presenting irregular menstrual cycles due oligo/anovulation, an important element PCOS's presentation leads infertility some patients' experience. associated insulin resistance consequent hyperinsulinemia metabolic disorders, seen Subsequently, affected at greater risk obesity, dyslipidemia, diabetes, cardiovascular diseases, particularly later life. rate mood namely depression anxiety, also increased this population. complex nature syndrome makes difficulties patient care, chronic emphasizes proactive stance when it comes treatment, but careful assessment elements disease.

Language: Английский

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Insulin‐like growth factor 2 mRNA‐binding protein 2‐regulated alternative splicing of nuclear factor 1 C‐type causes excessive granulosa cell proliferation in polycystic ovary syndrome

Cell Proliferation, Journal Year: 2022, Volume and Issue: 55(4)

Published: March 16, 2022

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder. Insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) serves as an HMGA2 target gene to promote the proliferation of granulosa cells (GCs). However, it still unclear whether IGF2BP2 participates in pathogenesis PCOS RNA binding (RBP). In this study, we aimed elucidate IGF2BP2-interacting transcripts, global transcriptome together with alternative splicing GCs eventually uncover potential mechanisms pathogenesis.The expression from patients was detected using quantitative reverse transcription PCR (RT-qPCR) and western blot. We captured by immunoprecipitation sequencing (RIP-seq) (RNA-seq). KGN transfected overexpressing plasmids nuclear 1 C-type (NFIC) siRNAs, were applied CCK-8, EdU TUNEL assays.IGF2BP2 highly expressed patients. As RBP, preferentially bound 3'and 5'UTRs mRNAs GGAC motif newly found GAAG motif. The overexpression changed profile cells. functioned regulate events cell through inhibiting exon skipping NFIC.In conclusion, demonstrated that promotes GC via regulating NFIC PCOS. findings help better understand roles

Language: Английский

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Chemerin: A Functional Adipokine in Reproductive Health and Diseases

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 1910 - 1910

Published: Aug. 7, 2022

As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin the cognate are also expressed in hypothalamus, pituitary gland, testis, ovary, placenta. Accumulating studies suggest that participates normal reproduction underlies pathological mechanisms of certain reproductive system diseases, including polycystic ovary syndrome (PCOS), preeclampsia, breast cancer. Herein, we present comprehensive review roles multiple processes human with brief discussion perspectives on future clinical applications.

Language: Английский

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Are epigenetic mechanisms and nutrition effective in male and female infertility?

Journal of Nutritional Science, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 1, 2023

This review discusses epigenetic mechanisms and the relationship of infertility in men women relation to parameters pertaining nutrition. The prevalence worldwide is 8-12 %, one out every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy nutrients non-nutrient compounds; more or less intake, methionine come into play occurrence infertility. It also interacts with vitamins B12, D B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin similar factors. To understand molecular regulating expression genes that affect infertility, environment, role genotype, age, health, nutrition changes individual's epigenotype must first be considered. will pave way for identification unknown causes Insufficient excessive intake certain macro micronutrients may contribute as well. In addition, it reported 5-10 % body weight loss, moderate physical activity nutritional interventions improvement insulin sensitivity development fertility. Processes pertain epigenetics carry alterations which are inherited yet not encoded via DNA sequence. Nutrition believed have an impact over effective pathogenesis several diseases like individuals different from healthy individuals. Infertility associated nutrients, bioactive components numerous other

Language: Английский

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Polycystic Ovarian Syndrome in Adolescents

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 25, 2023

Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological complex series of disorders that impacts woman throughout her lifespan. PCOS disorder hormonal imbalance occurring in women reproductive age. This characterized by high levels male androgens like testosterone. can lead to symptoms irregular periods, amenorrhea (absence menstruation), anovulation ovulation), hirsutism, acne, obesity. also causes metabolic impairment. Multiple peripherally arranged immature follicles about 2-5mm diameter are present the ovary. These do not mature due imbalances leading an menstrual cycle. fatal or life-threatening as its main complication infertility. be root cause serious medical conditions obesity, hypertension, type-2 diabetes mellitus insulin resistance, endometrial cancers, cancer, etc. Stress may hormone pituitary fluctuate. Since cycle hormone-based, there apparent irregularities.

Language: Английский

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