Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 80 - 80

Published: Jan. 1, 2025

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as the most common chronic disease, is soon to be leading indication for transplantation; however, diagnosis may remain occult decades. There a need biomarkers that identify patients at risk MASLD and progression optimize patient management outcomes. Lymph node adiposity (LNA) novel marker of identified within axillary lymph nodes on screening mammography. Recent studies have demonstrated correlation between LNA cardiometabolic cardiovascular risk. This study aimed investigate association evaluate potential mammographic serve an imaging biomarker MASLD. Methods: We women with pathology-proven who had biopsy mammogram 12 months biopsy. resulted in sample size 161 final analysis met inclusion criteria. evaluated through multiple measurements largest visualized mammography correlated histology. Statistical using univariable multivariable logistic regression odds ratios was performed R version 4.1.0 (2021), Foundation Computing Platform. Results: found significant LNA, defined (LN) length > 16 mm (p = 0.0004) remained after adjusting clinical factors, including body mass index (BMI). additionally metabolic steatohepatitis (MASH), via 0.0048). Conclusions: Mammographic helpful elevated development MASH.

Language: Английский

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Leptin, NK cells, and the weight of immunity: Insights into obesity

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113992 - 113992

Published: Jan. 5, 2025

Language: Английский

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Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 862 - 862

Published: Jan. 20, 2025

Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.

Language: Английский

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FABP4 as a therapeutic host target controlling SARS-CoV-2 infection

EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 30, 2025

Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset

Language: Английский

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Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

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Elevated levels of neutrophils with a pro-inflammatory profile in Turner syndrome across karyotypes

npj Genomic Medicine, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 6, 2025

Turner syndrome (TS) presents with multiple karyotypes, including 45,X monosomy and variants such as isochromosomes mosaicism, is characterized by several co-morbidities, metabolic conditions autoimmunity. Here, we investigated the genomic landscapes across a range of karyotypes. We show that TS have common autosomal methylome transcriptome, despite distinct karyotypic variations. All individuals lacked X chromosome p-arm, XIST expression from q-arm did not affect transcriptome or methylome, highlighting critical role missing p-arm its pseudoautosomal region 1. Furthermore, increased levels neutrophils neutrophil activation. The increase in was linked to clinical traits X-Y homologous gene TBL1X, suggesting genetic basis, which may lead neutrophil-driven inflammatory stress TS. Identifying activation could potentially mitigate progression towards more severe issues.

Language: Английский

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Human differentiated adipocytes can serve as surrogate mature adipocytes for adipocyte-derived extracellular vesicle analysis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract Obesity is a growing global health concern, contributing to diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. Adipose tissue dysfunction, characterized by abnormal adipokine secretion chronic inflammation, plays key role in these Adipose-derived extracellular vesicles (ADEVs) have emerged critical mediators obesity-related diseases. However, the study of mature adipocyte-derived EVs (mAdipo-EVs) limited due short lifespan adipocytes culture, low EV yields, abundance subpopulations circulation. Additionally, most studies rely on rodent models, which differences adipose biology compared humans. To overcome challenges, we developed standardized approach for differentiating human preadipocytes (preAdipos) into differentiated (difAdipos), produce high-yield, adipocyte (Adipo-EVs). Using visceral from bariatric surgical patients, isolated stromal vascular fraction (SVF) preAdipos difAdipos. Brightfield microscopy revealed that difAdipos exhibited morphological characteristics comparable (mAdipos) directly tissue, confirming their structural similarity. qPCR analysis demonstrated decreased preadipocyte markers increased markers, further validating successful differentiation. Functionally, lipolytic activity mAdipos, supporting functional resemblance native adipocytes. We then preAdipo-EVs difAdipo-EVs using tangential flow filtration them bulk single analysis. DifAdipo-EVs displayed classical adipocyte-specific with significant biomarker expression preAdipo-EVs. These findings demonstrate serve reliable surrogate adipocytes, offering consistent scalable source studying obesity its associated disorders.

Language: Английский

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Body weight in systemic lupus erythematosus is associated with disease activity and the adaptive immune system, independent of type I IFN

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

To explore the relationship between physique and immunological disturbances in systemic lupus erythematosus (SLE), we analyzed clinical, transcriptomic characteristics of patients with SLE relation to body mass index (BMI). Clinical were obtained from patient charts, serum cytokine levels measured. Phenotypes transcriptomes peripheral immune cells ImmuNexUT database BMI. Thirty-four included analysis. Fever mucocutaneous symptoms commonly observed a low BMI was negatively correlated disease activity (SLEDAI)-2K scores. Multiple regression analysis revealed that an independent explanatory variable for SLEDAI-2K scores, irrespective anti-dsDNA antibody or complement levels. Although interferon (IFN)-alpha IFN-gamma associated BMI, causal mediation showed had direct effect on IFN-alpha Immunophenotyping indicated primarily T cell subsets. BMI-related gene expression mainly enriched regulatory B several cellular metabolic pathways, including glucose metabolism-related pathways Th1 effector memory CD8+ cells, but not IFN signaling. We characterized profiles varying As identified as parameter explaining activity, cachexia is considered one active SLE. Additionally, influenced phenotypic alterations acquired These findings provide insights into pathogenesis

Language: Английский

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Comorbidity results of an obesity center

The European Research Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 19, 2025

Objectives: Obesity is linked to numerous severe health conditions, including type 2 diabetes mellitus, heart disease, hypertension, and stroke. This study aimed compare metabolic parameters anthropometric measurements between male female patients with obesity identify gender-based differences in obesity-related markers. Methods: prospective enrolled 393 obese (52 male, 341 female) from an outpatient clinic. After overnight fast (8-10 hours), blood samples were collected assess a range of parameters: complete count, fasting glucose, insulin, Hemoglobin A1c (HbA1c), Aspartate aminotransferase (AST), Alanine (ALT), Thyroid-stimulating hormone (TSH), total cholesterol, triglycerides, Low-density lipoprotein (LDL), High-density (HDL), 25-hydroxy vitamin D3 (25OHD3), ferritin, iron, B12. Homeostatic Model Assessment Insulin Resistance (HOMA-IR) Body Mass Index (BMI) calculated, while soft lean mass (SLM) percent body fat (PBF) also analyzed. Results: Males had significantly higher levels HOMA-IR, 25OHD3, hemoglobin, hematocrit, urea, ALT compared females (P<0.05 for all). Conversely, males lower HDL platelet (P<0.05). The prevalence thyroid disease was (P=0.027). Conclusions: Thyroid males. Additionally, such as urea elevated females,

Language: Английский

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