Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Abstract
Diabetic
retinopathy
(DR),
a
well-known
microvascular
complication
of
diabetes
mellitus,
remains
the
main
cause
vision
loss
in
working-age
adults
worldwide.
Up
to
now,
there
is
shortage
information
study
regarding
contributing
factors
DR
diabetes.
Accumulating
evidence
has
identified
glycemic
variability
(GV),
referred
fluctuations
blood
glucose
levels,
as
risk
factor
for
diabetes-related
complications.
Recent
reports
demonstrate
that
GV
plays
an
important
role
accounting
susceptibility
development.
However,
its
exact
pathogenesis
still
not
fully
understood.
In
this
review,
we
highlight
current
landscape
and
relevant
mechanisms
DR,
well
address
mechanism-based
therapeutic
strategies,
aiming
at
better
improving
quality
management
clinical
practice.
The
objective
of
this
real-world,
observational
study
was
to
evaluate
change
in
continuing
glucose
monitoring
(CGM)
metrics
for
1
year
after
CGM
initiation
adults
with
noninsulin-treated
type
2
diabetes
(T2D).
Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1 - 9
Published: Jan. 1, 2025
Objective:
To
explore
the
efficacy
and
safety
of
intermittent
use
flash
glucose
monitoring
(FGM)
for
improving
glycemic
control
in
Chinese
elderly
patients
with
type
2
diabetes
mellitus
(T2DM).
Methods:
This
is
a
prospective
observational
study
involving
T2DM
aged
≥
60
years.
The
period
spans
12
weeks,
participants
wearing
FGM
at
weeks
0,
5,
10.
Participants
were
divided
into
two
subgroups
based
on
HbA1c
enrollment:
<
7.0%
7.0%.
primary
outcome
was
level.
Secondary
outcomes
included
time
range
(3.9–
10mmol/L)
(TIR),
below
(<
3.9mmol/L)
(TBR),
above
(>
10.0mmol/L)
(TAR),
variability
(GV).
Results:
A
total
68
completed
12-week
follow-up
(age
67.9
±
5.2
years;
BMI
25.4
3.3kg/m²).
Overall
findings
revealed
that
compared
to
baseline,
decreased
from
7.81
1.25%
7.44±
1.10%
after
(p
0.001).
In
subgroup
analysis
7.0%,
results
showed
significant
reduction
0.51mmol/L
(8.36
0.95%
vs
7.75
0.97%,
p
And
there
TBR
7%
=
0.028).
Multiple
linear
regression
baseline
(β
−
0.529,
P<
0.001),
duration
0.341,
P
frequency
sensor
0.269,
0.043)
associated
Conclusion:
Intermittent
an
improvement
reduces
risk
hypoglycemia
T2DM.
Keywords:
monitoring,
mellitus,
HbA1c,
JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Background
Continuous
glucose
monitoring
(CGM)
has
improved
diabetes
management
but
remains
underused
among
low‐income
populations
who
have
a
higher
prevalence.
With
the
additional
consideration
of
socioeconomic
factors
limiting
resources
to
maintain
health,
further
understanding
effectiveness
CGM
in
marginalized
patients
is
needed.
This
scoping
review
synthesizes
evidence
on
health
outcomes
impacted
by
use
adults
with
type
2
mellitus
(T2DM)
receiving
care
settings.
Methods
PRISMA‐ScR
guidelines
were
used
identify
studies
through
PubMed,
Embase,
and
CINAHL.
A
search
strategy
combined
MeSH
terms
keywords
reviewing
titles
abstracts.
The
included
English‐language
using
from
inception
May
2024;
participants
18
years
or
older
T2DM,
majority
meeting
pre‐defined
status
study
being
conducted
setting.
Studies
pregnant
patients,
meta‐analyses,
systematic
reviews
excluded.
Two
reviewers
independently
performed
selection,
data
extraction,
quality
assessment.
authors
received
no
financial
support
for
this
research.
Results
identified
1176
studies,
198
duplicates,
resulting
978
screened
Forty‐six
underwent
full
text
review,
31
Ultimately,
15
(5
abstracts,
9
manuscripts,
1
case
report)
met
criteria.
led
reductions
hemoglobin
A1C
levels
across
settings
such
as
Federally
Qualified
Health
Centers,
clinics
serving
underinsured,
county
departments,
rural
clinics.
Other
benefits
reduced
hypoglycemia,
levels,
increased
time
range.
Discussion
described
showed
an
improvement
diabetes‐related
clinical
patients.
Limited
amount
was
main
limitation
review.
Insights
highlight
need
research
interventions
enhance
access
address
barriers
promote
equity
underserved
populations,
especially
becomes
available
over
counter.
Cardiovascular Diabetology,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Nov. 26, 2024
Abstract
Background
The
burden
of
atrial
fibrillation
(AF)
in
the
intensive
care
unit
(ICU)
remains
heavy.
Glycaemic
control
is
important
AF
management.
variability
(GV),
an
emerging
marker
glycaemic
control,
associated
with
unfavourable
prognosis,
and
abnormal
GV
prevalent
ICUs.
However,
impact
on
prognosis
patients
ICU
uncertain.
This
study
aimed
to
evaluate
relationship
between
all-cause
mortality
after
admission
at
short-,
medium-,
long-term
intervals
patients.
Methods
Data
was
obtained
from
Medical
Information
Mart
for
Intensive
Care
IV
3.0
database,
admissions
(2008–2019)
as
primary
analysis
cohort
(2020–2022)
external
validation
cohort.
Multivariate
Cox
proportional
hazards
models,
restricted
cubic
spline
analyses
were
used
assess
associations
outcomes.
Subsequently,
other
clinical
features
construct
machine
learning
(ML)
prediction
models
30-day
admission.
Results
included
8989
(age
76.5
[67.7–84.3]
years;
57.8%
male),
while
837
72.9
[65.3–80.2]
67.4%
male).
revealed
that
higher
quartiles
risk
(Q3:
HR
1.19,
95%CI
1.04–1.37;
Q4:
1.33,
1.16–1.52),
90-day
1.25,
1.11–1.40;
1.34,
1.29–1.50),
360-day
1.21,
1.09–1.33;
1.20–1.47)
mortality,
compared
lowest
quartile.
Moreover,
our
data
suggests
needs
be
contained
within
20.0%.
Among
all
ML
light
gradient
boosting
had
best
performance
(internal
validation:
AUC
[0.780],
G-mean
[0.551],
F1-score
[0.533];
[0.788],
[0.578],
[0.568]).
Conclusion
a
significant
predictor
short-term,
mid-term,
(the
potential
stratification
threshold
20.0%).
incorporating
demonstrated
high
efficiency
predicting
short-term
ranked
anterior
importance.
These
findings
underscore
valuable
biomarker
guiding
decisions
improving
patient
outcomes
this
high-risk
population.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 148 - 148
Published: Feb. 26, 2025
The
detection
of
small
molecules
is
critical
in
many
fields,
but
traditional
electrochemical
methods
often
exhibit
limited
accuracy.
construction
multi-mode
sensors
a
common
strategy
to
improve
However,
most
existing
rely
on
the
separate
analysis
each
mode
signal,
which
can
easily
lead
sensor
failure
when
deviation
between
different
results
too
large.
In
this
study,
we
propose
based
Prussian
Blue
(PB)
for
ascorbic
acid
(AA)
detection.
We
innovatively
integrate
back-propagation
artificial
neural
networks
(BP
ANNs)
comprehensively
process
three
collected
signal
data
sets,
successfully
solves
problem
caused
by
large
results,
and
greatly
improves
prediction
accuracy,
range,
anti-interference
sensor.
Our
findings
provide
an
effective
solution
optimizing
multi-modal
sensors,
show
broad
application
prospects
bioanalysis,
clinical
diagnosis,
related
fields.
Frontiers in Clinical Diabetes and Healthcare,
Journal Year:
2025,
Volume and Issue:
6
Published: March 13, 2025
Introduction
Continuous
Glucose
Monitoring
(CGM)
systems
are
crucial
in
diabetes
management,
offering
clinical
and
psychological
benefits
despite
operational
challenges.
Usability
assessment
of
real-time
intermittently-scanned
CGM
is
a
notable
research
gap.
This
study,
collaboration
with
patient
associations,
explores
usability
from
the
perspective
Italian
individuals
diabetes.
Methods
A
roundtable
discussion
association
representatives
was
conducted
to
discuss
usability,
followed
by
detailed
online
survey
281
patients
on
usage,
satisfaction,
feature
preferences.
Results
Findings
show
significant
positive
impact
Quality
Life
(87/100)
moderate
(66/100).
Core
functions
widely
used,
while
data
sharing
healthcare
professionals
underutilized.
The
study
offers
diverse
insights
into
both
data.
Conclusions
underscores
importance
management
highlights
need
for
continuous
technological
improvements.
It
emphasizes
role
associations
enhancing
communication
manufacturers
education.
Effective
between
vital
optimal
use,
advocating
personalized
care
strategies
tailored
individual
needs.
Background:
Devices
for
continuous
glucose
monitoring
(CGM)
have
been
developed
to
optimize
blood
control
and
liberate
people
with
diabetes
from
finger-prick
measurements.
Since
2016,
the
devices
reimbursed
in
Germany
receiving
insulin
therapy,
resulting
their
increased
use
among
type
1
(T1D)
2
(T2D).
We
investigated
prevalence
of
CGM
its
associated
factors
German
adults
2017
2021/2022.
Methods:
Participants
aged
18
years
or
older
diagnosed
were
identified
two
nationwide
population-based
telephone
surveys
(n
=
1396)
2021/2022
1456).
Prevalence
dynamics
examined
overall
stratified
by
sociodemographic
diabetes-related
characteristics.
Factors
obtained
logistic
regression
models.
Results:
The
was
8.2%
16.6%
An
increase
observed
across
all
subgroups
except
those
without
antidiabetic
medications.
31.1%
75.4%
T1D,
6.3%
13.6%
T2D,
14.6%
36.7%
users.
In
both
surveys,
younger
age,
use,
reporting
hypoglycemia
use.
addition,
2017,
higher
education
level
absence
obesity
whereas
2021/2022,
participation
self-management
program
self-assessed
quality
care
Conclusion:
Among
Germany,
about
twofold
within
5
years,
irrespective
factors.
Educational
inequality
diminished
over
time.
self-rated
recent
provides
further
evidence
support
Germany.
BMC Endocrine Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 31, 2025
Abstract
Background
Innovations
in
diabetes
technology
have
consistently
improved
outcomes
of
persons
with
type1
(PWDs).
However,
the
volumes
data
that
these
technologies
yield
require
different
workflows
to
alleviate
healthcare
professionals’
(HCPs)
workload
and
prevent
losing
relevant
between
visits
for
interpretation
treatment
adaptations.
CloudCare
is
a
population
health
management
tool
continuously
oversees
from
groups
individual
PWDs,
based
on
remote
monitoring,
screening
triaging
PWDs.
This
study
assesses
effect
satisfaction
HCPs’
glycemic
control
Methods
We
evaluated
6-month
follow-up
as
part
an
ongoing
prospective
cohort
analyzing
CloudCare.
Adult
PWDs
diagnosed
>
6
months
before
inclusion
were
enrolled.
The
primary
outcome
was
change
PWD
(DTSQc).
Secondary
included
number
type
contacts
HCPs
diabetes-related
distress
(PAID-5),
control.
Results
In
September
2024,
175
participants
had
baseline
available,
median
age
29.9
years
duration
17
years.
Differences
could
be
calculated
119
participants.
After
follow-up,
increase
PWDs’
(DTSQc)
+
6.0
(IQR
2–11;
p
<
0.001).
face-to-face
per
3
decreased
0.85
at
0.34
(
0.001)
months.
Diabetes-related
significantly
=
0.034),
compared
baseline.
Glucometrics
did
not
change,
TIR
79%
78%
after
0.39),
mean
glucose
indicator
(GMI)
50
mmol/mol
(6.7%)
all
timepoints.
Conclusions
adult
good
control,
decreases
HCPs,
while
increasing
maintaining
excellent
during
months,
showing
this
concept
can
applied
modern
care
high
density
availability.
Trial
registration
Clinicaltrials.gov
identifier:
NCT05431140;
date
21-6-2023.