Nutritional interventions to counteract the detrimental consequences of early-life stress DOI Creative Commons

J. Geertsema,

Hannah G. Juncker,

Lars Wilmes

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Exposure to stress during sensitive developmental periods comes with long term consequences for neurobehavioral outcomes and increases vulnerability psychopathology later in life. While we have advanced our understanding of the mechanisms underlying programming effects early-life (ES), these are not yet fully understood often hard target, making development effective interventions challenging. In recent years, others suggested that nutrition might be instrumental modulating possibly combatting ES-induced increased risk psychopathologies impairments. Nutritional strategies very promising as they relatively safe, cheap easy implement. Here, set out comprehensively review existing literature on nutritional aimed at counteracting ES preclinical clinical settings. We identified eighty six rodent ten human studies investigating a intervention ameliorate The evidence date, is too few heterogeneous terms interventions, thus allowing conclusions, however studies, despite their heterogeneity designs, used, measured, showed Furthermore, discuss possible involved beneficial brain after ES, including neuroinflammation, oxidative stress, hypothalamus-pituitary-adrenal axis regulation microbiome-gut-brain axis. Lastly, highlight critical gaps current knowledge make recommendations future research move field forward.

Language: Английский

Bridging the gap: Time to integrate sex and gender differences into research and clinical practice for improved health outcomes DOI Creative Commons
Roberta Gualtierotti

European Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The integration of sex and gender in medical research clinical practice is increasingly recognized as a cornerstone for achieving equitable health outcomes. Biological influence the manifestation, progression, treatment response numerous diseases. influences disease outcomes through genetic, hormonal, physiological factors, while impacts them via identity, societal roles behaviors. Historically, has focused predominantly on male body, leading to diagnostic therapeutic gaps women gender-diverse populations. In particular, remain underrepresented trials, suboptimal strategies addition, many conditions, such cardiovascular, metabolic neurological diseases, sex-specific variations risk factors presentation are prominent. present review discusses critical importance distinguishing between preclinical research, necessity incorporating these variables across all stages from study design analysis reporting studies trials. By distinct but interacting variables, we propose framework advance equity foster personalized, inclusive healthcare. This approach will promote development gender-sensitive guidelines, enhance accuracy tools, ultimately contribute improved individuals, regardless their or identity.

Language: Английский

Citations

2
What should We Do More for Gender Equity in Women\'s Health? DOI Open Access

Asım Kurjak,

Milan Stanojević,

Ulla Marton

et al.

Donald School Journal of Ultrasound in Obstetrics & Gynecology, Journal Year: 2025, Volume and Issue: 19(1), P. 30 - 33

Published: March 27, 2025

Language: Английский

Citations

0
Alzheimer disease seen through the lens of sex and gender DOI

Laura Castro‐Aldrete,

Melanie Einsiedler,

J Martínková

et al.

Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Womens Health Research Funding in Canada across 13 years suggests low funding levels with a narrow focus DOI Creative Commons
Laura Gravelsins, Tallinn F. L. Splinter,

Ahmad Mohammad

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Background Women’s health has historically been undervalued, underrepresented, and underfunded. Sex gender mandates were introduced in grant competitions to increase women’s research. This study aimed understand what type of research is being funded prioritized open Canada. Methods Publicly available Canadian Institute Health Research (CIHR) project abstracts from 2020 2023 coded for the mention sex, gender, two-spirit, lesbian, gay, bisexual, trans, queer plus (2S/LGBTQ+), female-specific assessed changes representation funding. A deeper analysis 2009-2020 was conducted assess if focused on 11 areas global disease burden death that disproportionately affect females, this evolved over time. Results The percentage mentioning 2S/LGBTQ+ doubled or quadrupled 2023, but remained at under 10% overall abstracts. In contrast, did not change time, ∼7% all Importantly, largely cancers (breast, gynecologic) pregnancy. We also examined funding top females across 13 years observed cancer accounted 2.07% funding, whereas other 10 collectively 2.21% years. Conclusions Despite integrated sex based analyses Canada, acknowledging which population explored remains 10%. Mandates are affecting grants. More efforts support beyond needed diversify pregnancy cancer. devoted factors key achieving personalized medicine improved outcomes everyone.

Language: Английский

Citations

0
Nutritional interventions to counteract the detrimental consequences of early-life stress DOI Creative Commons

J. Geertsema,

Hannah G. Juncker,

Lars Wilmes

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Exposure to stress during sensitive developmental periods comes with long term consequences for neurobehavioral outcomes and increases vulnerability psychopathology later in life. While we have advanced our understanding of the mechanisms underlying programming effects early-life (ES), these are not yet fully understood often hard target, making development effective interventions challenging. In recent years, others suggested that nutrition might be instrumental modulating possibly combatting ES-induced increased risk psychopathologies impairments. Nutritional strategies very promising as they relatively safe, cheap easy implement. Here, set out comprehensively review existing literature on nutritional aimed at counteracting ES preclinical clinical settings. We identified eighty six rodent ten human studies investigating a intervention ameliorate The evidence date, is too few heterogeneous terms interventions, thus allowing conclusions, however studies, despite their heterogeneity designs, used, measured, showed Furthermore, discuss possible involved beneficial brain after ES, including neuroinflammation, oxidative stress, hypothalamus-pituitary-adrenal axis regulation microbiome-gut-brain axis. Lastly, highlight critical gaps current knowledge make recommendations future research move field forward.

Language: Английский

Citations

0