Exercise, Nutrition, and Neuromuscular Electrical Stimulation for Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Management in Middle-Aged and Older Adults DOI Open Access

Shan Xu,

Shihfan Jack Tu,

Xiaoyu Hao

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1504 - 1504

Published: April 29, 2025

Background/Objective: Sarcopenic obesity (SO), a pathological syndrome characterized by the co-existence of diminished muscle mass and excessive adipose accumulation, significantly compromises quality life in older adults. The purpose this study was to systematically evaluate efficacy exercise, nutritional interventions, neuromuscular electrical stimulation (NMES) preventing managing SO middle-aged Methods: A comprehensive search conducted across PubMed, Web Science, Embase, Cochrane Library, CNKI for randomized controlled trials (RCTs) until January 2025. Meta-analyses were performed using random-effects model fixed-effects based on degree heterogeneity calculating mean differences (MD) with 95% confidence intervals (CI). Subgroup analyses compared intervention types. Results: Twenty-nine RCTs (1622 participants) included. Exercise interventions reduced body fat percentage (MD = −2.79%, CI: −3.94, −1.64, p < 0.001, I2 74%), −6.77 kg, −11.48, −2.06, 0.005, 98%), waist circumference −2.05 cm, −3.64, −0.46, 0.01, 0%) LDL-C (MD: −7.45 mg/dL, −13.82, −1.07, 0.02, 0%), while improving handgrip strength 2.35 1.99, 2.70, 52%) gait speed 0.19 m/s, 0.13, 0.24, 89%). Mixed training outperformed resistance-only regimens reducing enhancing functional outcomes. NMES −2.01%, −3.54, −0.48, 93%) −1.72 −2.35, −1.09, increasing Skeletal Muscle Index 0.26 kg/m2, 0.22, 0.29, 38%). Synergy supplementation amplified these effects. Nutritional modestly improved total fat-free 0.77 0.04, 1.50, 1.35 0.71, 2.00, but showed no significant impact metabolic markers (TG, TC, glucose, hemoglobin, HOMA-IR). Conclusions: Exercise, particularly multimodal combining aerobic resistance training, is cornerstone composition physical function SO. serves as an effective adjunct accelerating loss, strategies require integration exercise or prolonged implementation yield clinically meaningful Future research should prioritize standardized diagnostic criteria long-term assessments interventions.

Language: Английский

Unraveling the Disparity of Carbohydrate Utilization in Farmed Fish: Perspectives From Comparative Pancreatic Islet Biology DOI
Bingyuan Yang, Qinghui Ai, Kangsen Mai

et al.

Reviews in Aquaculture, Journal Year: 2025, Volume and Issue: 17(3)

Published: April 1, 2025

ABSTRACT The potential benefits of enhancing the capacity for carbohydrate utilization in farmed fish, particularly species with pronounced intolerance, are significant from a number perspectives. In recent decades, multitude research initiatives have focused on elucidating factors that influence as well biological limitations constrain this process. Despite substantial progress achieved thus far, dearth clarity persists regarding associated tolerance among various species. Evidence suggests that, mammals, pancreatic islet tissues teleosts act regulatory valve glucose assimilation and metabolism. However, precise intricacies remain to be fully elucidated subject ongoing endeavors fish objective review is provide comprehensive evaluation extant gaps domain endocrinology, aim identifying potentially impede Furthermore, it incorporates advancements biology physiological functions homeostasis zebrafish model mammalian animals more overview future directions fish. addition, we present prospective avenues inquiry concomitant challenges achieve profound comprehension fundamental mechanisms precipitate intolerance This expected benefit researchers specializing study metabolism

Language: Английский

Citations

0
Exercise, Nutrition, and Neuromuscular Electrical Stimulation for Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Management in Middle-Aged and Older Adults DOI Open Access

Shan Xu,

Shihfan Jack Tu,

Xiaoyu Hao

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1504 - 1504

Published: April 29, 2025

Background/Objective: Sarcopenic obesity (SO), a pathological syndrome characterized by the co-existence of diminished muscle mass and excessive adipose accumulation, significantly compromises quality life in older adults. The purpose this study was to systematically evaluate efficacy exercise, nutritional interventions, neuromuscular electrical stimulation (NMES) preventing managing SO middle-aged Methods: A comprehensive search conducted across PubMed, Web Science, Embase, Cochrane Library, CNKI for randomized controlled trials (RCTs) until January 2025. Meta-analyses were performed using random-effects model fixed-effects based on degree heterogeneity calculating mean differences (MD) with 95% confidence intervals (CI). Subgroup analyses compared intervention types. Results: Twenty-nine RCTs (1622 participants) included. Exercise interventions reduced body fat percentage (MD = −2.79%, CI: −3.94, −1.64, p < 0.001, I2 74%), −6.77 kg, −11.48, −2.06, 0.005, 98%), waist circumference −2.05 cm, −3.64, −0.46, 0.01, 0%) LDL-C (MD: −7.45 mg/dL, −13.82, −1.07, 0.02, 0%), while improving handgrip strength 2.35 1.99, 2.70, 52%) gait speed 0.19 m/s, 0.13, 0.24, 89%). Mixed training outperformed resistance-only regimens reducing enhancing functional outcomes. NMES −2.01%, −3.54, −0.48, 93%) −1.72 −2.35, −1.09, increasing Skeletal Muscle Index 0.26 kg/m2, 0.22, 0.29, 38%). Synergy supplementation amplified these effects. Nutritional modestly improved total fat-free 0.77 0.04, 1.50, 1.35 0.71, 2.00, but showed no significant impact metabolic markers (TG, TC, glucose, hemoglobin, HOMA-IR). Conclusions: Exercise, particularly multimodal combining aerobic resistance training, is cornerstone composition physical function SO. serves as an effective adjunct accelerating loss, strategies require integration exercise or prolonged implementation yield clinically meaningful Future research should prioritize standardized diagnostic criteria long-term assessments interventions.

Language: Английский

Citations

0