Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Language: Английский
Citations
19
Gastroenterology, Journal Year: 2024, Volume and Issue: unknown
Published: March 1, 2024
Non-responsive celiac disease (NRCD) is relatively common. It generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications CD disorders clinically mimicking CD, need be excluded. Novel therapies are being evaluated facilitate mucosal recovery, which might benefit NRCD patients. Refractory (RCD) rare currently divided into two types. The etiology RCD type 1 (RCDI) unclear, a possible switch gluten-independent autoimmunity suspected in some patients, while II (RCDII) represents low-grade intraepithelial lymphoma. RCDI remains diagnosis exclusion, requiring ruling out intake non-malignant causes villous atrophy. Diagnosis RCDII relies on the demonstration clonal population neoplastic lymphocytes with an atypical immunophenotype. responds open capsule budesonide, but latter has dismal prognosis due severe malnutrition frequent progression Enteropathy-associated T cell lymphoma more efficient therapy needed.
Language: Английский
Citations
16
Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 377 - 377
Published: Jan. 24, 2025
Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.
Language: Английский
Citations
2
The Lancet Regional Health - Europe, Journal Year: 2025, Volume and Issue: 50, P. 101201 - 101201
Published: Jan. 9, 2025
SummaryBackgroundCeliac disease (CeD) may be associated with elevated liver enzymes. However, little is known about the risk of chronic (CLD) various etiologies or major adverse outcomes (MALO) in CeD. We aimed to investigate long-term CLD patients CeD.MethodsSwedish nationwide cohort study. identified 48,027 biopsy-confirmed CeD between 1969 and 2017. Each patient was exactly matched ≤5 general population reference individuals (n = 231,909) followed through 2021. Flexible parametric survival models estimated adjusted hazard ratios (aHRs) any specific (i.e., viral hepatitis, metabolic dysfunction-associated steatotic [MASLD], alcohol-related disease, autoimmune disease) MALO (compensated/decompensated cirrhosis, hepatocellular carcinoma, transplantation, liver-related death).FindingsDuring a median follow-up 16.0 years, 649 1571 developed (incidence rate: 79.4 vs. 39.5/100,000 person-years). had higher developing than (aHR 2.01, 95%CI:1.82−2.22). This remained ≥25 years after diagnosis, giving one extra case per 110 until then. Positive associations were present for 4.86), MASLD 2.54), 1.51). Individuals at significantly incident 1.54). Sibling comparisons sensitivity analyses confirmed main findings.InterpretationCeD persistently increased CLD, although absolute low. Physicians should vigilant early signs dysfunction CeD.FundingEuropean Crohn's Colitis Organisation, Swedish Society Medical Research (project#: PG-23-0315-H-02), FORTE 2016-00424), Takeda, Swiss National Science Foundation P500PM_210866).
Language: Английский
Citations
1
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
1
Gastroenterology, Journal Year: 2024, Volume and Issue: 167(1), P. 183 - 193
Published: Feb. 13, 2024
Language: Английский
Citations
5
Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2008 - 2008
Published: June 25, 2024
Celiac disease (CD) is a chronic autoimmune disorder triggered by the ingestion of gluten-containing food genetically predisposed individuals. Hence, treatment CD consists permanent avoidance wheat, rye, barley, and other foods. Lifelong adherence to gluten-free diet (GFD) improves symptoms CD, but recent evidence suggests it also associated with higher risk for hepatic steatosis coexistence or emergence cardiometabolic factors. Moreover, liver reported some authors as potential extraintestinal complication itself. Recent nomenclature changes designate association between at least one five factors metabolic dysfunction-associated steatotic (MASLD). An extended network potentially causative underlying MAFLD before after dietary therapy implemented, was recently described. The individualized these patients less supported evidence, most current recommendations relying on empiric clinical judgment. This review focuses associations injury, either an manifestation side effect GFD, referring therapeutic strategies
Language: Английский
Citations
4
Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: 19(7), P. 1897 - 1903
Published: June 29, 2024
Language: Английский
Citations
4
Journal of Human Nutrition and Dietetics, Journal Year: 2025, Volume and Issue: 38(1)
Published: Jan. 27, 2025
ABSTRACT Introduction A gluten‐free (GF) diet, the only treatment for people living with coeliac disease (CD), is challenging, and international guidelines highlight valuable role of healthcare professionals in enabling self‐management. The study aimed to explore acceptability telephone online video consultations adults CD. Methods cross‐sectional consisting an paper survey was promoted Results Data from 496 CD (87% female, 96% White) are presented, 44% were adhering GF diet. Over half (58%) very confident understanding food labels supermarkets, whereas 38% when shopping online. largest proportion patients preferred in‐person appointments (44%), 20% reporting no preference 21% preferring appointments. Only 15% consultations; these, 97% technology. higher a lower household income requested ‘in‐person’ compared those (65% vs. 45% ( p < 0.01)). Likewise, 58% without degree qualification degree‐educated = 0.027). Conclusions We significant prefer appointment. enabled views broader range digitally contribute study. With global shift towards telemedicine resources, access digital literacy important consideration equitable optimize patient self‐management
Language: Английский
Citations
0
Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: 10, P. 100278 - 100278
Published: Jan. 30, 2025
Language: Английский
Citations
0