Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver DOI Open Access
Marc Nater, Michael David Brügger,

Virginia Cecconi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

The liver is an important metastatic organ that contains many innate immune cells, yet little known about their role in anti-metastatic defense. We investigated how invariant natural killer T (iNKT) cells influence colorectal cancer-derived metastasis using different models immunocompetent mice. found hepatic iNKT promote by creating a supportive niche for disseminated cancer cells. Mechanistically, respond to disseminating producing the fibrogenic cytokines IL-4 and IL-13 TCR-independent manner. Selective abrogation of sensing stellate prevented transdifferentiation into extracellular matrix-producing myofibroblasts, which hindered outgrowth This study highlights novel tumor-promoting axis driven initial stages metastasis.

Language: Английский

Molecular principles underlying aggressive cancers DOI Creative Commons
Ruth Nussinov, Bengi Ruken Yavuz, Hyunbum Jang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 16, 2025

Language: Английский

Citations

3
Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Olink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer DOI Creative Commons
Chong Xiao, Hao Wu, Jing Long

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(2), P. 599 - 611

Published: Jan. 6, 2025

Comprehensive protein profiling in intestinal tissues provides detailed information about the pathogenesis of colorectal cancer (CRC). This study quantified expression levels 92 oncology-related proteins tumors, paired para-carcinoma tissues, and remote normal from a cohort 52 CRC patients utilizing Olink technology. The proteomic profile closely resembled that while distinctly differing tumors. Among 68 differentially expressed (DEPs) identified between tumor WISP-1, ESM-1, TFPI-2 showed most pronounced alterations exhibited relatively strong correlations. These markers also presented highest AUC values for distinguishing tissue types. Bioinformatic analysis DEPs revealed plasma membrane PI3K-AKT signaling pathway were among enriched GO terms KEGG pathways. Furthermore, although is typically recognized as suppressor, both enzyme linked immunosorbent assay (ELISA) analyses have demonstrated its significantly elevated tumors compared with tissues. To best our knowledge, this first to proteome using work offers valuable insights into potential biomarkers therapeutic targets CRC, complementing circulating proteins.

Language: Английский

Citations

0
Evaluation of the Prognostic Value of Four ECM-Associated Genes in Recurrence and Metastasis of Colorectal Cancer DOI Open Access
Seçil Durel Avcıoğlu,

Sulgun Charyeva,

Beyza Doğanay Erdoğan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

ABSTRACT Colorectal cancer is a significant public health issue due to its high incidence and mortality rate, especially when diagnosed late. Identifying new biomarkers that can predict the diagnosis prognosis of CRC critical reducing rate disease. This study tested relationship four extracellular matrix genes (COL1A1, COL5A1, THBS2 FN1) with at mRNA protein levels. Our previous studies identified these as candidate prognostic for CRC. They were analysed in two cohorts: retrospective (130 tumours 70 healthy colon tissues) prospective (160 paired normal tissues 180 serum samples). Accordingly, cohort, COL1A1 (p>0.0001), COL5A1 (0.0001) FN1 (0.001) expressed higher levels compared controls by qRT-PCR metastatic cases non-metastatic cases. In same immunohistochemistry analysis showed increasing correlated addition, associated OS (p>0.011), RFS DMFS (0.042), (0.013), (p>0.003) (p>0.039). COL1A1, found be tumour tissue matched primary 160 tissues. this unexpectedly than where samples also ELISA, (p>0.05), (p>0.05) sera As result, genes, which have different data on their effects literature, poor both

Language: Английский

Citations

0
Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer DOI Creative Commons
Can Wu,

Xiao Wei Zhang,

Manman Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 31, 2025

Language: Английский

Citations

0
Shaping the microenvironment in peritoneal metastases DOI
Qihao Ren, Louis Vermeulen

Nature Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Unveiling the multifaceted roles of long non-coding RNA CTBP1-DT in human diseases: Special attention to its microprotein-encoding potential DOI

Jingjie Yang

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 268, P. 155870 - 155870

Published: Feb. 26, 2025

Language: Английский

Citations

0
Integrating multi-omics and machine learning methods reveals the metabolism of amino acids and derivatives-related signature in colorectal cancer DOI Creative Commons
Jian Yue, Huiying Fang,

Qian Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 26, 2025

Objective The metabolism of amino acids and derivatives (MAAD) is closely related to the occurrence development colorectal cancer (CRC), but specific regulatory mechanisms are not yet clear. This study aims explore role MAAD in progression ultimately identify key molecules that may become potential therapeutic targets for CRC. Methods integrates bulk transcriptome single-cell analyze MAAD-related genes from multiple levels. Subsequently, numerous machine learning methods were incorporated construct prognostic models, infiltration immune cells, tumor heterogeneity, mutation burden, pathway changes under different modes analyzed. Finally, identified experimental validation. Results We successfully constructed models Nomograms based on molecules. There was a notable survival benefit observed low-risk patients when contrasted with their high-risk counterparts. In addition, group had poorer response immunotherapy stronger heterogeneity compared group. Further research found by knocking down gene. LSM8, malignant characteristics cell lines significantly alleviated, suggesting LSM8 target. Conclusion gene likely involved CRC could be hopeful target intervention.

Language: Английский

Citations

0
The Role of Prophylactic or Adjuvant Hyperthermic Intraperitoneal Therapy in Appendiceal and Colorectal Cancer Peritoneal Metastasis DOI

Monique H Gandawidjaja,

Belain Eyob,

Abigail Chmiel

et al.

Surgical Oncology Clinics of North America, Journal Year: 2025, Volume and Issue: 34(2), P. 227 - 240

Published: Jan. 7, 2025

Language: Английский

Citations

0
Complete blood counts as potential risk factors of early dissemination to liver and lungs in resected colorectal cancer: a retrospective cohort study DOI Creative Commons
Marta Popęda, Jolanta Żok, Bartłomiej Tomasik

et al.

International Journal of Colorectal Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 21, 2025

Abstract Purpose Liver and lung metastases demonstrate distinct biological, particularly immunological, characteristics. We investigated whether preoperative complete blood count (CBC) parameters, which may reflect the immune system condition, predict early dissemination to liver lungs in colorectal cancer (CRC). Methods In this retrospective single-centre study, we included 268 resected CRC cases with 2-year follow-up analysed CBC for association or metastasis development. Next, selected clinicopathological parameters were uni- multivariable Cox regression. Independent factors affecting metastasis-free survival incorporated into composite scores, further evaluated receiver operating characteristic (ROC) curves dichotomised using a modified, specificity-focused, Youden approach identify high-risk patients. Results Compared patients, related decreases red cells, haematocrit, lymphocytes elevated monocyte-to-lymphocyte ratio, while lower eosinophil counts. A score of independent (erythrocytopenia, lymphocyte pN) yielded HR 8.01 (95% CI 3.45–18.57, p < 0.001) liver-specific (MFS). For lung-specific MFS, combination eosinopenia, pN primary tumour location showed 13.69 4.34–43.20, 0.001). Conclusion Early are associated partially divergent peripheral features. propose simple, clinically implementable based on routinely assessed patients an increased risk lungs. After validation cohorts, these scores provide easily available prognostic information.

Language: Английский

Citations

0