Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Current Hepatology Reports, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 13, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Separation is a fundamental process in natural living systems. Their separation capabilities have inspired the design of various materials and devices. Despite some progress having been made, comprehensive overview still lacking. In this Perspective, we first review development technologies. We then summarize typical systems exhibiting superior from compositions microstructures to mechanisms. Next, highlight key advancements nature-inspired integrated Finally, propose future research directions opportunities, emphasizing importance physical chemical internal external stimulus regulation. These devices show great potential biomedicine, environmental remediation, energy conversion, food safety, analysis testing.
Language: Английский
Citations
0
Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0
Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Autoimmune hepatitis (AIH) is a relatively infrequent and complex liver disease characterized by acute or chronic inflammation, interface in histology examination, elevation of immunoglobulin G (IgG), production autoantibodies, often responsive to immunosuppression. The incidence AIH has been increasing worldwide, affecting people all ages sexes. represents diagnostic challenge because its heterogeneous presentation the lack pathognomonic findings. Even when treated, can remain progressive disease. In this review, we present recent data on natural history developing evidence management patients with AIH. This review outlines clinical presentation, risk factors linked poorer outcomes, algorithm, current strategies for individuals living remains challenge, new tools better diagnosis stratification are needed. addition, treatments needed as complete response achieved less than 60% cases, intolerance first-line treatment frequent. use biological seems improve rate minimize side effects medication increasingly prevalent
Language: Английский
Citations
0
World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(15)
Published: April 17, 2025
The integrity and functionality of the hepatic microcirculation are essential for maintaining liver health, which is influenced by sex genetic background. Understanding these variations crucial addressing disparities in disease outcomes. To investigate sexual dimorphism heterogeneity microcirculatory function mice. We assessed microhemodynamics BALB/c, C57BL/6J, KM mouse strains using laser Doppler flowmetry wavelet analysis. analyzed serum levels alanine transaminase, glutamic acid aminotransferase, total bile acid, protein, alkaline phosphatase, glucose. Histological immunohistochemical staining were employed to quantify microvascular density expression cluster differentiation (CD) 31, estrogen receptor α, β. Statistical analyses, including Mantel test Pearson correlation, conducted determine relationships among function, microcirculation, marcocirculation between different sexes across backgrounds. identified sex-based all strains, with males exhibiting higher perfusion erythrocyte concentration, but lower blood velocity. Strain-specific differences evident, particularly endothelial oscillatory characteristics concentration. No sex-dependent observed, while significant CD31 observed. correlations highlighted indicators. Our findings indicate influence on highlighting necessity incorporating both background into physiology studies potential management strategies.
Language: Английский
Citations
0
Inflammation and Regeneration, Journal Year: 2025, Volume and Issue: 45(1)
Published: May 3, 2025
Aging-associated dysbiosis leads to chronic inflammation and the development of a range aging-related diseases. The gut microbiota crosstalks with host by providing lipid metabolites modulating metabolic functions. However, precise mechanism which regulates aging is unknown. objective this study was examine impact on transcriptome lipidome associated in mouse liver. RNA-sequencing conducted livers young aged male female-specific pathogen-free (SPF) germ-free (GF) mice comprehensively analyze transcriptomic alterations aging. We also reanalyzed our previously reported results aging-associated changes hepatic investigate microbiota-dependent signatures In contrast findings mice, were attenuated female GF compared those SPF mice. particular, gene sets inflammatory (i.e., tissue remodeling) found be suppressed ChIP-Atlas database predicted that transcription factors sex differences may involved signature Significant profile observed between including bile acids, sterol sulfates, lysophospholipids, oxidized triacylglycerols, vitamin D, phytoceramides. Moreover, notable identified quality phospholipids sphingolipids. Integrated lipidomic analysis candidate enzymes responsible for change profiles offer new insights into molecular mechanisms through phenotypes such as liver, possibly metabolism sex-dependent manner.
Language: Английский
Citations
0
Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: May 19, 2025
The liver is a central metabolic organ, but also hosting unique immune microenvironment to sustain homeostasis and proper defense measures against injury threats in healthy individuals. Liver macrophages, mostly represented by the tissue-resident Kupffer cells bone marrow- or monocyte-derived are intricately involved various aspects of disease, including tissue injury, inflammation, fibrogenesis repair mechanisms. We review recent findings on defining macrophage landscape their functions diseases with aim highlighting potential targets for therapeutic interventions. A comprehensive literature search PubMed Google Scholar was conducted identify relevant up date. macrophages orchestrate key homeostatic pathogenic processes liver. Thus, targeting represents an attractive strategy drug development, e.g. ameliorate steatohepatitis fibrosis. However, translation from fundamental research therapies remains challenging due versatile nature compartment. Recent major technical advances such as single-cell spatially-resolved omics approaches deepened our understanding biology at molecular level. Yet, further studies needed suitable, etiology- stage-dependent strategies treatment diseases.
Language: Английский
Citations
0
Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
3