Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease DOI Creative Commons

A. Hettenbach,

Tanja Elger,

Muriel Huss

et al.

Pathophysiology, Journal Year: 2025, Volume and Issue: 32(2), P. 13 - 13

Published: March 25, 2025

Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum cholesterol levels and inflammation, both of which are dysregulated in inflammatory bowel disease (IBD). Free (FC) the various types cholesteryl ester (CE) have different functions body. However, it is not yet known whether these lipids undergo parallel changes male female patients with active IBD, nor PCSK9 correlates severity either sex. The present study measured PCSK9, FC, 15 CE species IBD patients, focusing on associations molecules sex, each other, severity. Methods: 80 (42 males 38 females) 24 controls (12 12 were by enzyme-linked immunosorbent assay. In addition, FC 53 randomly selected 16 determined direct flow injection analysis (FIA) using a high-resolution hybrid quadrupole-orbitrap mass spectrometer (FIA-FTMS). Results: Serum comparable did correlate patients. There was no discernible difference between Crohn’s (CD) those ulcerative colitis (UC). almost all decreased but related to decrease diarrhea compared normal stool consistency appears be Bile acids regulate levels, positively correlated fecal secondary bile UC CD. This association also existed could evaluated women due small sample size. Conclusions: reduction observed only males, while remained within ranges sexes. It can hypothesized that blocking may further reduce adverse effects IBD.

Language: Английский

Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease DOI Creative Commons

A. Hettenbach,

Tanja Elger,

Muriel Huss

et al.

Pathophysiology, Journal Year: 2025, Volume and Issue: 32(2), P. 13 - 13

Published: March 25, 2025

Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum cholesterol levels and inflammation, both of which are dysregulated in inflammatory bowel disease (IBD). Free (FC) the various types cholesteryl ester (CE) have different functions body. However, it is not yet known whether these lipids undergo parallel changes male female patients with active IBD, nor PCSK9 correlates severity either sex. The present study measured PCSK9, FC, 15 CE species IBD patients, focusing on associations molecules sex, each other, severity. Methods: 80 (42 males 38 females) 24 controls (12 12 were by enzyme-linked immunosorbent assay. In addition, FC 53 randomly selected 16 determined direct flow injection analysis (FIA) using a high-resolution hybrid quadrupole-orbitrap mass spectrometer (FIA-FTMS). Results: Serum comparable did correlate patients. There was no discernible difference between Crohn’s (CD) those ulcerative colitis (UC). almost all decreased but related to decrease diarrhea compared normal stool consistency appears be Bile acids regulate levels, positively correlated fecal secondary bile UC CD. This association also existed could evaluated women due small sample size. Conclusions: reduction observed only males, while remained within ranges sexes. It can hypothesized that blocking may further reduce adverse effects IBD.

Language: Английский

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