Autophagy in major human diseases

The EMBO Journal, Journal Year: 2021, Volume and Issue: 40(19)

Published: Aug. 30, 2021

Review30 August 2021Open Access Autophagy in major human diseases Daniel J Klionsky orcid.org/0000-0002-7828-8118 Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA Search for more papers by this author Giulia Petroni Department Radiation Oncology, Weill Cornell Medical College, New York, NY, Ravi K Amaravadi Medicine, Pennsylvania, Philadelphia, PA, Abramson Cancer Center, Eric H Baehrecke Molecular, Cell and Biology, Massachusetts School, Worcester, MA, Andrea Ballabio orcid.org/0000-0003-1381-4604 Telethon Institute Genetics Pozzuoli, Italy Translational Sciences, Section Pediatrics, Federico II University, Naples, Molecular Human Genetics, Baylor College Jan Dan Duncan Neurological Research Texas Children Hospital, Houston, TX, Patricia Boya orcid.org/0000-0003-3045-951X Margarita Salas Center Biological Research, Spanish National Council, Madrid, Spain José Manuel Bravo-San Pedro Faculty Physiology, Complutense Networked Biomedical Neurodegenerative Diseases (CIBERNED), Ken Cadwell Kimmel Biology Medicine at the Skirball York Grossman School Microbiology, Division Gastroenterology Hepatology, Langone Health, Francesco Cecconi orcid.org/0000-0002-5614-4359 Stress Survival Unit, Autophagy, Recycling Disease (CARD), Danish Society Copenhagen, Denmark Pediatric Onco-Hematology Gene Therapy, IRCCS Bambino Gesù Children's Rome, Rome 'Tor Vergata', Augustine M Choi Pulmonary Critical Care Joan Sanford I. York-Presbyterian Mary E Nephrology Hypertension, Charleen T Chu orcid.org/0000-0002-5052-8271 Pathology, Pittsburgh Pittsburgh, Patrice Codogno orcid.org/0000-0002-5492-3180 Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France Université de Maria Isabel Colombo Laboratorio Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto Histología Embriología (IHEM)-Universidad Nacional Cuyo, CONICET- Facultad Ciencias Médicas, Mendoza, Argentina Ana Cuervo orcid.org/0000-0002-0771-700X Developmental Albert Einstein Bronx, Aging Studies, Vojo Deretic Inflammation Metabolism (AIM, Excellence, Mexico Health Albuquerque, NM, Ivan Dikic orcid.org/0000-0001-8156-9511 Biochemistry II, Goethe Frankfurt, Frankfurt am Main, Germany Buchmann Zvulun Elazar Biomolecular The Weizmann Science, Rehovot, Israel Eeva-Liisa Eskelinen Biomedicine, Turku, Finland Gian Fimia orcid.org/0000-0003-4438-3325 Sapienza Epidemiology, Preclinical Advanced Diagnostics, Infectious 'L. Spallanzani' IRCCS, David A Gewirtz orcid.org/0000-0003-0437-4934 Pharmacology Toxicology, Virginia Commonwealth Richmond, VA, Douglas R Green Immunology, St. Jude Memphis, TN, Malene Hansen Burnham Prebys Discovery Program Development, Aging, Regeneration, La Jolla, CA, Marja Jäättelä orcid.org/0000-0001-5950-7111 Death Metabolism, & Disease, Cellular Terje Johansen orcid.org/0000-0003-1451-9578 Group, Tromsø—The Arctic Norway, Tromsø, Norway Gábor Juhász Szeged, Hungary Anatomy, Eötvös Loránd Budapest, Vassiliki Karantza Merck Co., Inc., Kenilworth, NJ, Claudine Kraft orcid.org/0000-0002-3324-4701 ZBMZ, Freiburg, CIBSS - Centre Integrative Signalling Guido Kroemer orcid.org/0000-0002-9334-4405 Recherche des Cordeliers, Equipe Labellisée par Ligue Contre le Cancer, Sorbonne Université, Inserm U1138, Universitaire France, Metabolomics Platforms, Gustave Roussy, Villejuif, Pôle Biologie, Hôpital Européen Georges Pompidou, AP-HP, Suzhou Systems Chinese Academy Suzhou, China Karolinska Women's Stockholm, Sweden Nicholas Ktistakis Programme, Babraham Cambridge, UK Sharad Kumar orcid.org/0000-0001-7126-9814 South Australia, Adelaide, SA, Australia Carlos Lopez-Otin orcid.org/0000-0001-6964-1904 Departamento Bioquímica Biología Medicina, Instituto Universitario Oncología del Principado Asturias (IUOPA), Universidad Oviedo, Centro Investigación Biomédica Red Cáncer (CIBERONC), Kay F Macleod Ben May Gordon W-338, Chicago, IL, Frank Madeo Biosciences, NAWI Graz, Austria BioTechMed-Graz, Field Excellence BioHealth – Jennifer Martinez Immunity, Laboratory, Environmental NIH, Triangle Park, NC, Alicia Meléndez Department, Queens City Flushing, Graduate PhD Programs Noboru Mizushima orcid.org/0000-0002-6258-6444 Tokyo, Japan Christian Münz orcid.org/0000-0001-6419-1940 Viral Immunobiology, Experimental Zurich, Switzerland Josef Penninger Biotechnology Austrian (IMBA), Vienna BioCenter (VBC), Vienna, British Columbia, Vancouver, BC, Canada Rushika Perera orcid.org/0000-0003-2435-2273 California, San Francisco, Helen Diller Family Comprehensive Mauro Piacentini orcid.org/0000-0003-2919-1296 "Tor Vergata", Laboratory Cytology Russian Saint Petersburg, Russia Fulvio Reggiori orcid.org/0000-0003-2652-2686 Cells Systems, Section, Groningen, Netherlands C Rubinsztein Cambridge Dementia Kevin Ryan Beatson Glasgow, Junichi Sadoshima Cardiovascular Rutgers Jersey Newark, Laura Santambrogio Sandra Edward Meyer Caryl Englander Precision Luca Scorrano orcid.org/0000-0002-8515-8928 Istituto Veneto di Medicina Molecolare, Padova, Hans-Uwe Simon Pharmacology, Bern, Clinical Immunology Allergology, Sechenov Moscow, Fundamental Kazan Federal Kazan, Anna Katharina Kennedy Rheumatology, NDORMS, Oxford, Anne Simonsen orcid.org/0000-0003-4711-7057 Basic Oslo, Reprogramming, Oslo Hospital Montebello, Alexandra Stolz orcid.org/0000-0002-3340-439X Nektarios Tavernarakis orcid.org/0000-0002-5253-1466 Biotechnology, Foundation Technology-Hellas, Heraklion, Crete, Greece Sharon Tooze orcid.org/0000-0002-2182-3116 Francis Crick London, Tamotsu Yoshimori orcid.org/0000-0001-9787-3788 Osaka Suita, Intracellular Membrane Dynamics, Frontier Integrated Science Division, Open Transdisciplinary Initiatives (OTRI), Junying Yuan Interdisciplinary on Chemistry, Shanghai Organic Shanghai, Harvard Boston, Zhenyu Yue Neurology, Friedman Brain Icahn Mount Sinai, Qing Zhong orcid.org/0000-0001-6979-955X Key Differentiation Apoptosis Ministry Education, Pathophysiology, Jiao Tong (SJTU-SM), Lorenzo Galluzzi Corresponding Author [email protected] orcid.org/0000-0003-2257-8500 Dermatology, Yale Haven, CT, Pietrocola orcid.org/0000-0002-2930-234X Biosciences Nutrition, Huddinge, mor

Language: Английский

---

Telomeres: history, health, and hallmarks of aging

Cell, Journal Year: 2021, Volume and Issue: 184(2), P. 306 - 322

Published: Jan. 1, 2021

Language: Английский

---

Sex differences in biological aging with a focus on human studies

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 13, 2021

Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping individual's aging trajectory and subsequent disease risks. There substantial individual variability in between men women. In general, women live longer than men, consistent with lower ages as assessed molecular biomarkers, but there paradox. Women are frailer have worse health at end of life, while still perform better physical function examinations. Moreover, many age-related diseases show sex-specific patterns. this review, we aim to summarize current knowledge on sexual dimorphism human studies, support from animal research, illnesses. We also attempt place it context theories aging, well discuss explanations for sex differences, example, sex-chromosome linked mechanisms hormonally driven differences.

Language: Английский

---

Immune ageing at single-cell resolution

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(8), P. 484 - 498

Published: Nov. 23, 2021

Language: Английский

---

Mechanisms and Regulation of Cellular Senescence

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 13173 - 13173

Published: Dec. 6, 2021

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which cells remain metabolically active and secrete range pro-inflammatory proteolytic factors as part the senescence-associated secretory phenotype. There are different types senescent cells, can be induced response to many DNA damage signals. Senescent accumulate tissues organs where they have distinct physiological pathological functions. Despite this diversity, all must able survive nondividing while protecting themselves from positive feedback loops linked constant activation response. This capacity requires changes core cellular programs. Understanding how cell undergo extensive their transcriptional programs, metabolism, heterochromatin patterns, structures induce common is crucial preventing cancer development/progression improving health during aging. In review, we discuss continuously evolve after initial highlight unifying features that define state.

Language: Английский

---

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

Nature Aging, Journal Year: 2021, Volume and Issue: 1(3), P. 295 - 308

Published: March 15, 2021

Language: Английский

---

Biological aging processes underlying cognitive decline and neurodegenerative disease

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(10)

Published: May 15, 2022

Alzheimer's disease and related dementias (ADRD) are among the top contributors to disability mortality in later life. As with many chronic conditions, aging is single most influential factor development of ADRD. Even older adults who remain free dementia throughout their lives, cognitive decline neurodegenerative changes appreciable advancing age, suggesting shared pathophysiological mechanisms. In this Review, we provide an overview cognition, brain morphology, neuropathological protein accumulation across lifespan humans, complementary mechanistic evidence from animal models. Next, highlight selected processes that differentially regulated disease, including aberrant autophagy, mitochondrial dysfunction, cellular senescence, epigenetic changes, cerebrovascular inflammation, lipid dysregulation. We summarize research clinical translational studies link biological underlying ADRD pathogenesis. Targeting fundamental may represent a yet relatively unexplored avenue attenuate both age-related Collaboration fields geroscience neuroscience, coupled new models more closely align human processes, necessary advance novel therapeutic discovery realm.

Language: Английский

---

In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice

Nature Aging, Journal Year: 2022, Volume and Issue: 2(3), P. 243 - 253

Published: March 7, 2022

Language: Английский

---

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 28, 2021

Abstract Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis 256,523 Europeans aged 60 years over from 22 cohorts we identify 15 loci associated with weakness (European Working Group on Sarcopenia Older People definition: n = 48,596 cases, 18.9% total), including 12 not implicated previous analyses continuous measures grip strength. Loci include genes reportedly involved autoimmune disease ( HLA-DQA1 p 4 × 10 −17 ), arthritis GDF5 −13 cell cycle control cancer protection, regulation transcription, others the development maintenance musculoskeletal system. Using Mendelian randomization report possible overlapping causal pathways, diabetes susceptibility, haematological parameters, immune We conclude that adults has distinct mechanisms strength, several pathways considered be hallmarks ageing.

Language: Английский

---

Intrinsic Capacity: Validation of a New WHO Concept for Healthy Aging in a Longitudinal Chinese Study

The Journals of Gerontology Series A, Journal Year: 2021, Volume and Issue: 77(1), P. 94 - 100

Published: Aug. 3, 2021

Abstract Background The World Health Organization has proposed a model of healthy aging built around the concept functional ability, comprising an individual’s intrinsic capacity, physical and social environment they occupy, interactions between two. However, these constructs have been poorly defined. We examined structure capacity in representative sample Chinese population aged 60 years older assessed its value predicting declining performance instrumental activities daily living (IADLs) (ADLs) using similar methods to construct validation previously undertaken English cohort. Methods Deidentified data were accessed on 7 643 participants China Retirement Longitudinal Study 2011 2013 waves. Incrementally related structural equation modeling was applied, including exploratory confirmatory factor analysis, path analysis. Multiple linear regression tested validity, simple serial mediation models predictive validity. Results Factor loadings for showed clear capacity: 1 general with 5 subfactors—locomotor, cognitive, psychological sensory capacities, vitality (reflecting underlying physiologic changes). Intrinsic predicted both IADLs (standardized coefficient (SE) −0.324 (0.02), p < .001) ADLs (−0.227 (0.03), .001), after accounting age, sex, education, wealth, number chronic diseases. Each characteristic associated providing strong Conclusions Assessment provides valuable information subsequent functioning beyond that afforded by other personal factors, multimorbidity.

Language: Английский

---