DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort DOI Creative Commons
Anne K. Bozack, Sheryl L. Rifas‐Shiman, Diane R. Gold

et al.

Clinical Epigenetics, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 12, 2023

Abstract Background Epigenetic age acceleration (EAA) and epigenetic gestational (EGAA) are biomarkers of physiological development may be affected by the perinatal environment. The aim this study was to evaluate performance clocks identify biological sociodemographic correlates EGAA EAA at birth in childhood. In Project Viva pre-birth cohort, DNA methylation measured nucleated cells cord blood (leukocytes red cells, N = 485) leukocytes early (N 120, median 3.2 years) mid-childhood 460, 7.7 years). We calculated (EGA; Bohlin Knight clocks) (EA; Horvath skin & clocks), respective measures EAA. evaluated relative chronological using correlations absolute error. tested for associations maternal-child characteristics with mutually adjusted linear models controlling estimated cell type proportions. also EA childhood Results EGA strongly correlated (Bohlin r 0.82, p < 0.001). were weakly age, but moderately ( 0.45–0.65). Maternal smoking during pregnancy associated higher [ B (95% CI) 1.17 weeks (− 0.09, 2.42)] [0.34 years (0.03, 0.64)]. Female newborns children had lower [− 0.17 0.30, − 0.04)] 2.88 4.41, 1.35)] [early childhood: 0.3 0.60, 0.01); mid-childhood: 0.48 0.77, 0.18)] than males. When comparing self-reported Asian, Black, Hispanic, more one race or other racial/ethnic groups White, we identified significant differences mid-childhood, varied across clocks. positively Conclusions child sex multiple timepoints. Further research provide insight into relationship between factors, pediatric aging, health lifespan.

Language: Английский

The pathobiology of neurovascular aging DOI
Monica M. Santisteban, Costantino Iadecola

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 49 - 70

Published: Jan. 1, 2025

Language: Английский

Citations

3
Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases DOI Creative Commons
Jun Tang, Yue Liang, Ying Xu

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The blood proteome contains biomarkers of ageing and age-associated diseases, but such markers are rarely validated longitudinally. Here we map the longitudinal in 7,565 serum samples from a cohort 3,796 middle-aged elderly adults across three time points over 9-year follow-up period. We pinpoint 86 ageing-related proteins that exhibit signatures associated with 32 clinical traits incidence 14 major chronic diseases. Leveraging machine-learning model, pick 22 these to generate proteomic healthy score (PHAS), capable predicting cardiometabolic further identify gut microbiota as modifiable factor influencing PHAS. Our data constitute valuable resource offer useful insights into roles providing potential targets for intervention therapeutics promote ageing. Tang, Yue, Xu colleagues several thousand individuals period

Language: Английский

Citations

2
Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care DOI Creative Commons
Diala Haykal, Frédéric Flament,

Pascale Mora

et al.

International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT The concept of aging has evolved from being primarily attributed to genetic factors recognizing the critical role epigenetic mechanisms. Recent advancements, such as clocks, have provided tools assess biological age and offer insights into processes at molecular level. In aesthetic dermatology, understanding these allows for more personalized, effective interventions targeting root causes skin aging. This review explores interplay changes, aging, potential personalized care enhance longevity rejuvenation. is based on an extensive literature search conducted across PubMed other scientific databases. Studies focused mechanisms DNA methylation, histone modifications, their relationship Particular attention was given recent advancements in including Horvath's Clock GrimAge, implications dermatological treatments. Epigenetic Clock, demonstrated utility assessing through methylation markers, revealing actionable processes. Energy‐based devices like fractional lasers radiofrequency shown promise reversing age‐related promoting collagen synthesis, reducing age. Additionally, lifestyle diet, sleep, circadian rhythm alignment significantly influence health. Integrating dermatology represents a paradigm shift rejuvenation, allowing treatments that address visible signs underlying Using clocks provides framework tailoring individual patient needs, optimizing outcomes, extending results. Future research should focus longitudinal studies, accessibility, ethical considerations fully harness epigenetics health overall well‐being.

Language: Английский

Citations

2
Major depression and the biological hallmarks of aging DOI Creative Commons

Erica C. Lorenzo,

George A. Kuchel, Chia‐Ling Kuo

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 83, P. 101805 - 101805

Published: Nov. 21, 2022

Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity outcome. In recent years, several lines of evidence have suggested that individuals with MDD an elevated risk age-related adverse outcomes across lifespan. This review provided a significant overlap between biological abnormalities in changes commonly observed during aging process (i.e., hallmarks aging). Based on such evidence, we formulate mechanistic model showing how can be common denominator mediate health MDD. Finally, proposed roadmap for novel studies investigate intersection biology MDD, including use geroscience-guided interventions, as senolytics, delay or improve major depression targeting aging.

Language: Английский

Citations

64
DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort DOI Creative Commons
Anne K. Bozack, Sheryl L. Rifas‐Shiman, Diane R. Gold

et al.

Clinical Epigenetics, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 12, 2023

Abstract Background Epigenetic age acceleration (EAA) and epigenetic gestational (EGAA) are biomarkers of physiological development may be affected by the perinatal environment. The aim this study was to evaluate performance clocks identify biological sociodemographic correlates EGAA EAA at birth in childhood. In Project Viva pre-birth cohort, DNA methylation measured nucleated cells cord blood (leukocytes red cells, N = 485) leukocytes early (N 120, median 3.2 years) mid-childhood 460, 7.7 years). We calculated (EGA; Bohlin Knight clocks) (EA; Horvath skin & clocks), respective measures EAA. evaluated relative chronological using correlations absolute error. tested for associations maternal-child characteristics with mutually adjusted linear models controlling estimated cell type proportions. also EA childhood Results EGA strongly correlated (Bohlin r 0.82, p < 0.001). were weakly age, but moderately ( 0.45–0.65). Maternal smoking during pregnancy associated higher [ B (95% CI) 1.17 weeks (− 0.09, 2.42)] [0.34 years (0.03, 0.64)]. Female newborns children had lower [− 0.17 0.30, − 0.04)] 2.88 4.41, 1.35)] [early childhood: 0.3 0.60, 0.01); mid-childhood: 0.48 0.77, 0.18)] than males. When comparing self-reported Asian, Black, Hispanic, more one race or other racial/ethnic groups White, we identified significant differences mid-childhood, varied across clocks. positively Conclusions child sex multiple timepoints. Further research provide insight into relationship between factors, pediatric aging, health lifespan.

Language: Английский

Citations

38